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Gene: MEIS2 |
Gene summary for MEIS2 |
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Gene information | Species | Human | Gene symbol | MEIS2 | Gene ID | 4212 |
Gene name | Meis homeobox 2 | |
Gene Alias | CPCMR | |
Cytomap | 15q14 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A024R9L4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4212 | MEIS2 | AEH-subject1 | Human | Endometrium | AEH | 2.57e-21 | 6.19e-01 | -0.3059 |
4212 | MEIS2 | AEH-subject2 | Human | Endometrium | AEH | 1.97e-19 | 6.27e-01 | -0.2525 |
4212 | MEIS2 | AEH-subject3 | Human | Endometrium | AEH | 3.21e-24 | 6.66e-01 | -0.2576 |
4212 | MEIS2 | AEH-subject4 | Human | Endometrium | AEH | 8.92e-23 | 7.27e-01 | -0.2657 |
4212 | MEIS2 | AEH-subject5 | Human | Endometrium | AEH | 1.74e-06 | 3.34e-01 | -0.2953 |
4212 | MEIS2 | EEC-subject1 | Human | Endometrium | EEC | 3.47e-12 | 4.73e-01 | -0.2682 |
4212 | MEIS2 | EEC-subject2 | Human | Endometrium | EEC | 7.33e-32 | 8.51e-01 | -0.2607 |
4212 | MEIS2 | EEC-subject3 | Human | Endometrium | EEC | 6.62e-03 | -2.85e-02 | -0.2525 |
4212 | MEIS2 | EEC-subject4 | Human | Endometrium | EEC | 4.61e-15 | 5.14e-01 | -0.2571 |
4212 | MEIS2 | EEC-subject5 | Human | Endometrium | EEC | 1.54e-13 | 4.75e-01 | -0.249 |
4212 | MEIS2 | GSM5276935 | Human | Endometrium | EEC | 4.01e-02 | -9.90e-02 | -0.123 |
4212 | MEIS2 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.49e-06 | 1.24e-01 | -0.1869 |
4212 | MEIS2 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.26e-05 | 8.81e-02 | -0.1875 |
4212 | MEIS2 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.10e-06 | 9.98e-02 | -0.1883 |
4212 | MEIS2 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 7.85e-04 | -1.00e-01 | -0.1917 |
4212 | MEIS2 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.69e-03 | -7.96e-02 | -0.1916 |
4212 | MEIS2 | LZE4T | Human | Esophagus | ESCC | 6.69e-06 | 1.58e-01 | 0.0811 |
4212 | MEIS2 | LZE5T | Human | Esophagus | ESCC | 2.73e-03 | 2.17e-01 | 0.0514 |
4212 | MEIS2 | LZE8T | Human | Esophagus | ESCC | 3.77e-03 | 2.09e-01 | 0.067 |
4212 | MEIS2 | LZE21T | Human | Esophagus | ESCC | 3.13e-05 | 3.31e-01 | 0.0655 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00096128 | Endometrium | AEH | response to mechanical stimulus | 42/2100 | 216/18723 | 2.58e-04 | 3.04e-03 | 42 |
GO:00457877 | Endometrium | AEH | positive regulation of cell cycle | 56/2100 | 313/18723 | 2.73e-04 | 3.14e-03 | 56 |
GO:190370614 | Endometrium | AEH | regulation of hemopoiesis | 63/2100 | 367/18723 | 3.81e-04 | 4.10e-03 | 63 |
GO:004563716 | Endometrium | AEH | regulation of myeloid cell differentiation | 40/2100 | 210/18723 | 5.49e-04 | 5.52e-03 | 40 |
GO:003009916 | Endometrium | AEH | myeloid cell differentiation | 62/2100 | 381/18723 | 1.67e-03 | 1.36e-02 | 62 |
GO:000931410 | Endometrium | AEH | response to radiation | 70/2100 | 456/18723 | 3.99e-03 | 2.68e-02 | 70 |
GO:00459317 | Endometrium | AEH | positive regulation of mitotic cell cycle | 23/2100 | 121/18723 | 7.76e-03 | 4.33e-02 | 23 |
GO:000961213 | Endometrium | EEC | response to mechanical stimulus | 45/2168 | 216/18723 | 6.17e-05 | 9.28e-04 | 45 |
GO:190370615 | Endometrium | EEC | regulation of hemopoiesis | 67/2168 | 367/18723 | 1.01e-04 | 1.40e-03 | 67 |
GO:004578713 | Endometrium | EEC | positive regulation of cell cycle | 59/2168 | 313/18723 | 1.04e-04 | 1.44e-03 | 59 |
GO:004563717 | Endometrium | EEC | regulation of myeloid cell differentiation | 42/2168 | 210/18723 | 2.72e-04 | 3.09e-03 | 42 |
GO:003009917 | Endometrium | EEC | myeloid cell differentiation | 64/2168 | 381/18723 | 1.40e-03 | 1.14e-02 | 64 |
GO:004593113 | Endometrium | EEC | positive regulation of mitotic cell cycle | 25/2168 | 121/18723 | 2.76e-03 | 1.97e-02 | 25 |
GO:000931413 | Endometrium | EEC | response to radiation | 71/2168 | 456/18723 | 5.69e-03 | 3.42e-02 | 71 |
GO:00073467 | Endometrium | EEC | regulation of mitotic cell cycle | 70/2168 | 457/18723 | 8.76e-03 | 4.74e-02 | 70 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:0030099111 | Esophagus | ESCC | myeloid cell differentiation | 232/8552 | 381/18723 | 1.22e-09 | 2.90e-08 | 232 |
GO:004593116 | Esophagus | ESCC | positive regulation of mitotic cell cycle | 83/8552 | 121/18723 | 2.78e-07 | 4.08e-06 | 83 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MEIS2 | SNV | Missense_Mutation | c.992N>A | p.Arg331Lys | p.R331K | O14770 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
MEIS2 | SNV | Missense_Mutation | novel | c.839G>C | p.Arg280Thr | p.R280T | O14770 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MEIS2 | SNV | Missense_Mutation | c.1360N>A | p.Ala454Thr | p.A454T | O14770 | protein_coding | deleterious_low_confidence(0.01) | benign(0.007) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MEIS2 | SNV | Missense_Mutation | c.155N>A | p.Gly52Asp | p.G52D | O14770 | protein_coding | deleterious(0.01) | possibly_damaging(0.57) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MEIS2 | SNV | Missense_Mutation | c.91C>T | p.Arg31Trp | p.R31W | O14770 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MEIS2 | SNV | Missense_Mutation | novel | c.505N>A | p.Asp169Asn | p.D169N | O14770 | protein_coding | deleterious(0.03) | benign(0.251) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MEIS2 | SNV | Missense_Mutation | c.1009N>T | p.Pro337Ser | p.P337S | O14770 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MEIS2 | SNV | Missense_Mutation | novel | c.1178N>A | p.Ser393Tyr | p.S393Y | O14770 | protein_coding | tolerated_low_confidence(0.06) | benign(0.225) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MEIS2 | SNV | Missense_Mutation | c.1366A>C | p.Ser456Arg | p.S456R | O14770 | protein_coding | tolerated_low_confidence(0.07) | benign(0) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MEIS2 | SNV | Missense_Mutation | c.158C>T | p.Ala53Val | p.A53V | O14770 | protein_coding | tolerated(0.13) | benign(0.069) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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