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Gene: MCM10 |
Gene summary for MCM10 |
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Gene information | Species | Human | Gene symbol | MCM10 | Gene ID | 55388 |
Gene name | minichromosome maintenance 10 replication initiation factor | |
Gene Alias | CNA43 | |
Cytomap | 10p13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q7L590 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55388 | MCM10 | P2T-E | Human | Esophagus | ESCC | 7.94e-07 | 2.26e-01 | 0.1177 |
55388 | MCM10 | P4T-E | Human | Esophagus | ESCC | 8.00e-03 | 1.26e-01 | 0.1323 |
55388 | MCM10 | P5T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.72e-01 | 0.1327 |
55388 | MCM10 | P16T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.30e-01 | 0.1153 |
55388 | MCM10 | P21T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.38e-01 | 0.1617 |
55388 | MCM10 | P24T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.85e-01 | 0.1287 |
55388 | MCM10 | P31T-E | Human | Esophagus | ESCC | 9.44e-07 | 2.11e-01 | 0.1251 |
55388 | MCM10 | P32T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.74e-01 | 0.1666 |
55388 | MCM10 | P37T-E | Human | Esophagus | ESCC | 4.27e-06 | 2.10e-01 | 0.1371 |
55388 | MCM10 | P52T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.50e-01 | 0.1555 |
55388 | MCM10 | P76T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.21e-01 | 0.1207 |
55388 | MCM10 | P79T-E | Human | Esophagus | ESCC | 1.96e-05 | 2.15e-01 | 0.1154 |
55388 | MCM10 | P83T-E | Human | Esophagus | ESCC | 3.53e-13 | 6.07e-01 | 0.1738 |
55388 | MCM10 | P91T-E | Human | Esophagus | ESCC | 5.34e-06 | 6.81e-01 | 0.1828 |
55388 | MCM10 | P107T-E | Human | Esophagus | ESCC | 8.98e-03 | 1.18e-01 | 0.171 |
55388 | MCM10 | P130T-E | Human | Esophagus | ESCC | 3.89e-12 | 4.56e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:00062612 | Esophagus | ESCC | DNA-dependent DNA replication | 100/8552 | 151/18723 | 2.61e-07 | 3.94e-06 | 100 |
GO:00062701 | Esophagus | ESCC | DNA replication initiation | 27/8552 | 34/18723 | 6.01e-05 | 4.62e-04 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MCM10 | SNV | Missense_Mutation | c.727C>G | p.Gln243Glu | p.Q243E | Q7L590 | protein_coding | tolerated(0.16) | benign(0.11) | TCGA-EK-A2PL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
MCM10 | SNV | Missense_Mutation | c.1716N>C | p.Met572Ile | p.M572I | Q7L590 | protein_coding | tolerated(0.33) | benign(0.01) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
MCM10 | SNV | Missense_Mutation | c.404N>C | p.Val135Ala | p.V135A | Q7L590 | protein_coding | tolerated(0.74) | benign(0) | TCGA-MY-A913-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
MCM10 | SNV | Missense_Mutation | rs558495502 | c.1670N>T | p.Ser557Leu | p.S557L | Q7L590 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-Q1-A6DW-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
MCM10 | SNV | Missense_Mutation | c.469C>T | p.Arg157Trp | p.R157W | Q7L590 | protein_coding | deleterious(0.02) | benign(0.332) | TCGA-VS-A9U5-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
MCM10 | SNV | Missense_Mutation | novel | c.2046G>T | p.Lys682Asn | p.K682N | Q7L590 | protein_coding | deleterious(0.01) | possibly_damaging(0.815) | TCGA-5M-AATA-01 | Colorectum | colon adenocarcinoma | Unknown | Unknown | I/II | Unknown | Unknown | Unknown |
MCM10 | SNV | Missense_Mutation | rs756598324 | c.659G>A | p.Arg220Gln | p.R220Q | Q7L590 | protein_coding | tolerated(0.25) | benign(0.023) | TCGA-A6-2677-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Ancillary | leucovorin | SD |
MCM10 | SNV | Missense_Mutation | rs368268628 | c.1508N>A | p.Arg503Gln | p.R503Q | Q7L590 | protein_coding | tolerated(0.59) | benign(0.001) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MCM10 | SNV | Missense_Mutation | novel | c.1439N>G | p.Lys480Arg | p.K480R | Q7L590 | protein_coding | deleterious(0.03) | benign(0.13) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MCM10 | SNV | Missense_Mutation | rs766602619 | c.1313N>A | p.Arg438Gln | p.R438Q | Q7L590 | protein_coding | tolerated(0.08) | benign(0.026) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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