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Gene: MBOAT7 |
Gene summary for MBOAT7 |
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Gene information | Species | Human | Gene symbol | MBOAT7 | Gene ID | 79143 |
Gene name | membrane bound O-acyltransferase domain containing 7 | |
Gene Alias | BB1 | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q96N66 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79143 | MBOAT7 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.60e-15 | 5.69e-01 | -0.1954 |
79143 | MBOAT7 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.02e-07 | 1.16e+00 | -0.2602 |
79143 | MBOAT7 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.55e-13 | 5.66e-01 | -0.1464 |
79143 | MBOAT7 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.01e-02 | 3.30e-01 | -0.1001 |
79143 | MBOAT7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.71e-06 | 4.67e-01 | -0.059 |
79143 | MBOAT7 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.11e-02 | 4.83e-01 | -0.1706 |
79143 | MBOAT7 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.42e-06 | 5.27e-01 | -0.2061 |
79143 | MBOAT7 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.80e-02 | 2.86e-01 | 0.0674 |
79143 | MBOAT7 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.93e-06 | 4.55e-01 | 0.3859 |
79143 | MBOAT7 | A015-C-203 | Human | Colorectum | FAP | 2.79e-06 | -1.08e-01 | -0.1294 |
79143 | MBOAT7 | A001-C-108 | Human | Colorectum | FAP | 7.05e-05 | -1.00e-01 | -0.0272 |
79143 | MBOAT7 | A002-C-205 | Human | Colorectum | FAP | 1.15e-02 | -1.12e-01 | -0.1236 |
79143 | MBOAT7 | A015-C-006 | Human | Colorectum | FAP | 3.32e-02 | -1.31e-01 | -0.0994 |
79143 | MBOAT7 | A015-C-104 | Human | Colorectum | FAP | 5.39e-07 | -1.73e-01 | -0.1899 |
79143 | MBOAT7 | A002-C-016 | Human | Colorectum | FAP | 1.07e-02 | -1.59e-01 | 0.0521 |
79143 | MBOAT7 | A015-C-002 | Human | Colorectum | FAP | 4.19e-02 | -2.09e-01 | -0.0763 |
79143 | MBOAT7 | A002-C-116 | Human | Colorectum | FAP | 1.79e-07 | -1.80e-01 | -0.0452 |
79143 | MBOAT7 | A018-E-020 | Human | Colorectum | FAP | 3.54e-04 | -2.05e-01 | -0.2034 |
79143 | MBOAT7 | F034 | Human | Colorectum | FAP | 9.12e-05 | -1.71e-01 | -0.0665 |
79143 | MBOAT7 | CRC-3-11773 | Human | Colorectum | CRC | 9.20e-03 | 2.44e-01 | 0.2564 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030258 | Colorectum | AD | lipid modification | 67/3918 | 212/18723 | 1.66e-04 | 2.27e-03 | 67 |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0045017 | Colorectum | AD | glycerolipid biosynthetic process | 69/3918 | 252/18723 | 8.33e-03 | 4.88e-02 | 69 |
GO:0046486 | Colorectum | SER | glycerolipid metabolic process | 82/2897 | 392/18723 | 2.26e-03 | 2.17e-02 | 82 |
GO:00066441 | Colorectum | SER | phospholipid metabolic process | 79/2897 | 383/18723 | 3.94e-03 | 3.24e-02 | 79 |
GO:00450171 | Colorectum | SER | glycerolipid biosynthetic process | 55/2897 | 252/18723 | 4.47e-03 | 3.56e-02 | 55 |
GO:00302581 | Colorectum | SER | lipid modification | 47/2897 | 212/18723 | 6.01e-03 | 4.38e-02 | 47 |
GO:00066501 | Colorectum | SER | glycerophospholipid metabolic process | 64/2897 | 306/18723 | 6.41e-03 | 4.60e-02 | 64 |
GO:00302582 | Colorectum | MSS | lipid modification | 57/3467 | 212/18723 | 1.64e-03 | 1.49e-02 | 57 |
GO:00302583 | Colorectum | FAP | lipid modification | 52/2622 | 212/18723 | 2.84e-05 | 6.49e-04 | 52 |
GO:0008654 | Colorectum | FAP | phospholipid biosynthetic process | 54/2622 | 253/18723 | 8.88e-04 | 9.08e-03 | 54 |
GO:00066502 | Colorectum | FAP | glycerophospholipid metabolic process | 62/2622 | 306/18723 | 1.54e-03 | 1.38e-02 | 62 |
GO:0021987 | Colorectum | FAP | cerebral cortex development | 28/2622 | 114/18723 | 1.80e-03 | 1.55e-02 | 28 |
GO:00066442 | Colorectum | FAP | phospholipid metabolic process | 74/2622 | 383/18723 | 2.24e-03 | 1.83e-02 | 74 |
GO:0046474 | Colorectum | FAP | glycerophospholipid biosynthetic process | 44/2622 | 211/18723 | 3.98e-03 | 2.76e-02 | 44 |
GO:0021543 | Colorectum | FAP | pallium development | 36/2622 | 169/18723 | 6.06e-03 | 3.81e-02 | 36 |
GO:00450172 | Colorectum | FAP | glycerolipid biosynthetic process | 50/2622 | 252/18723 | 6.32e-03 | 3.95e-02 | 50 |
GO:0030900 | Colorectum | FAP | forebrain development | 70/2622 | 379/18723 | 8.64e-03 | 4.98e-02 | 70 |
GO:00086541 | Colorectum | CRC | phospholipid biosynthetic process | 49/2078 | 253/18723 | 7.07e-05 | 1.51e-03 | 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MBOAT7 | SNV | Missense_Mutation | rs759456879 | c.217N>A | p.Ala73Thr | p.A73T | Q96N66 | protein_coding | tolerated(0.44) | benign(0.003) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MBOAT7 | SNV | Missense_Mutation | rs377603361 | c.941G>A | p.Arg314His | p.R314H | Q96N66 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-MA-AA3Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MBOAT7 | SNV | Missense_Mutation | novel | c.1176N>C | p.Gln392His | p.Q392H | Q96N66 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MBOAT7 | SNV | Missense_Mutation | novel | c.1063T>G | p.Trp355Gly | p.W355G | Q96N66 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-VS-A9UL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
MBOAT7 | SNV | Missense_Mutation | novel | c.107N>T | p.Ala36Val | p.A36V | Q96N66 | protein_coding | tolerated(0.2) | benign(0.067) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MBOAT7 | SNV | Missense_Mutation | c.1088A>G | p.Tyr363Cys | p.Y363C | Q96N66 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
MBOAT7 | SNV | Missense_Mutation | c.800C>A | p.Ala267Asp | p.A267D | Q96N66 | protein_coding | tolerated(0.6) | benign(0.013) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
MBOAT7 | SNV | Missense_Mutation | c.1115N>A | p.Cys372Tyr | p.C372Y | Q96N66 | protein_coding | deleterious(0) | possibly_damaging(0.794) | TCGA-CM-6170-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MBOAT7 | SNV | Missense_Mutation | novel | c.283N>T | p.Pro95Ser | p.P95S | Q96N66 | protein_coding | deleterious(0) | possibly_damaging(0.832) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MBOAT7 | SNV | Missense_Mutation | rs754520819 | c.1109N>T | p.Pro370Leu | p.P370L | Q96N66 | protein_coding | deleterious(0) | possibly_damaging(0.757) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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