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Gene: MAZ |
Gene summary for MAZ |
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Gene information | Species | Human | Gene symbol | MAZ | Gene ID | 4150 |
Gene name | MYC associated zinc finger protein | |
Gene Alias | PUR1 | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P56270 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4150 | MAZ | GSM4909293 | Human | Breast | IDC | 1.29e-06 | 2.38e-01 | 0.1581 |
4150 | MAZ | GSM4909297 | Human | Breast | IDC | 1.31e-03 | -1.58e-01 | 0.1517 |
4150 | MAZ | GSM4909304 | Human | Breast | IDC | 6.10e-25 | 5.20e-01 | 0.1636 |
4150 | MAZ | GSM4909306 | Human | Breast | IDC | 3.73e-03 | 2.82e-01 | 0.1564 |
4150 | MAZ | GSM4909311 | Human | Breast | IDC | 4.07e-10 | -7.51e-02 | 0.1534 |
4150 | MAZ | GSM4909312 | Human | Breast | IDC | 4.69e-02 | 6.05e-02 | 0.1552 |
4150 | MAZ | GSM4909313 | Human | Breast | IDC | 2.51e-02 | 2.20e-03 | 0.0391 |
4150 | MAZ | GSM4909319 | Human | Breast | IDC | 9.93e-14 | -5.46e-02 | 0.1563 |
4150 | MAZ | GSM4909321 | Human | Breast | IDC | 2.51e-04 | -2.78e-03 | 0.1559 |
4150 | MAZ | M1 | Human | Breast | IDC | 7.04e-04 | 3.40e-01 | 0.1577 |
4150 | MAZ | NCCBC11 | Human | Breast | DCIS | 2.20e-02 | 3.65e-01 | 0.1232 |
4150 | MAZ | NCCBC14 | Human | Breast | DCIS | 1.26e-03 | 1.62e-01 | 0.2021 |
4150 | MAZ | NCCBC2 | Human | Breast | DCIS | 1.31e-02 | 2.58e-01 | 0.1554 |
4150 | MAZ | NCCBC6 | Human | Breast | DCIS | 1.52e-06 | 6.36e-01 | 0.2095 |
4150 | MAZ | P1 | Human | Breast | IDC | 2.42e-06 | 1.12e-01 | 0.1527 |
4150 | MAZ | P2 | Human | Breast | IDC | 3.62e-02 | 2.40e-01 | 0.21 |
4150 | MAZ | DCIS2 | Human | Breast | DCIS | 1.77e-30 | 7.69e-02 | 0.0085 |
4150 | MAZ | LZE4T | Human | Esophagus | ESCC | 3.29e-05 | 1.22e-01 | 0.0811 |
4150 | MAZ | LZE8T | Human | Esophagus | ESCC | 7.46e-07 | 7.60e-02 | 0.067 |
4150 | MAZ | LZE20T | Human | Esophagus | ESCC | 3.02e-05 | 1.64e-01 | 0.0662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200123314 | Breast | IDC | regulation of apoptotic signaling pathway | 82/1434 | 356/18723 | 6.27e-20 | 5.93e-17 | 82 |
GO:200123414 | Breast | IDC | negative regulation of apoptotic signaling pathway | 49/1434 | 224/18723 | 1.45e-11 | 2.58e-09 | 49 |
GO:004349111 | Breast | IDC | protein kinase B signaling | 27/1434 | 211/18723 | 5.92e-03 | 4.26e-02 | 27 |
GO:200123324 | Breast | DCIS | regulation of apoptotic signaling pathway | 81/1390 | 356/18723 | 3.51e-20 | 3.31e-17 | 81 |
GO:200123424 | Breast | DCIS | negative regulation of apoptotic signaling pathway | 48/1390 | 224/18723 | 1.70e-11 | 3.22e-09 | 48 |
GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
GO:2001234111 | Esophagus | ESCC | negative regulation of apoptotic signaling pathway | 161/8552 | 224/18723 | 1.24e-15 | 8.09e-14 | 161 |
GO:00063673 | Esophagus | ESCC | transcription initiation from RNA polymerase II promoter | 56/8552 | 77/18723 | 1.30e-06 | 1.59e-05 | 56 |
GO:000635211 | Esophagus | ESCC | DNA-templated transcription, initiation | 86/8552 | 130/18723 | 1.88e-06 | 2.19e-05 | 86 |
GO:00063532 | Esophagus | ESCC | DNA-templated transcription, termination | 15/8552 | 21/18723 | 1.54e-02 | 4.96e-02 | 15 |
GO:200123312 | Liver | Cirrhotic | regulation of apoptotic signaling pathway | 163/4634 | 356/18723 | 2.62e-18 | 4.43e-16 | 163 |
GO:20012347 | Liver | Cirrhotic | negative regulation of apoptotic signaling pathway | 102/4634 | 224/18723 | 8.40e-12 | 5.60e-10 | 102 |
GO:0006367 | Liver | Cirrhotic | transcription initiation from RNA polymerase II promoter | 31/4634 | 77/18723 | 1.91e-03 | 1.20e-02 | 31 |
GO:200123322 | Liver | HCC | regulation of apoptotic signaling pathway | 226/7958 | 356/18723 | 7.26e-16 | 5.68e-14 | 226 |
GO:200123412 | Liver | HCC | negative regulation of apoptotic signaling pathway | 145/7958 | 224/18723 | 1.33e-11 | 5.36e-10 | 145 |
GO:00063671 | Liver | HCC | transcription initiation from RNA polymerase II promoter | 52/7958 | 77/18723 | 7.87e-06 | 9.27e-05 | 52 |
GO:0006352 | Liver | HCC | DNA-templated transcription, initiation | 78/7958 | 130/18723 | 4.19e-05 | 4.11e-04 | 78 |
GO:200123320 | Oral cavity | OSCC | regulation of apoptotic signaling pathway | 242/7305 | 356/18723 | 6.66e-29 | 3.24e-26 | 242 |
GO:200123420 | Oral cavity | OSCC | negative regulation of apoptotic signaling pathway | 148/7305 | 224/18723 | 1.71e-16 | 1.36e-14 | 148 |
GO:00063522 | Oral cavity | OSCC | DNA-templated transcription, initiation | 74/7305 | 130/18723 | 2.56e-05 | 2.39e-04 | 74 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
MAZ | STM | Cervix | CC | PSMD3,SRSF1,PSAT1, etc. | 1.29e-01 | ![]() |
MAZ | LUM | Prostate | Tumor | KIF22,PPDPF,MZT2A, etc. | 7.55e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAZ | deletion | Frame_Shift_Del | rs769505112 | c.1425delN | p.Ala478ProfsTer47 | p.A478Pfs*47 | P56270 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
MAZ | deletion | Frame_Shift_Del | rs769505112 | c.1432delG | p.Ala478ProfsTer47 | p.A478Pfs*47 | P56270 | protein_coding | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
MAZ | SNV | Missense_Mutation | novel | c.686N>T | p.Thr229Ile | p.T229I | P56270 | protein_coding | tolerated(0.1) | benign(0.335) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
MAZ | SNV | Missense_Mutation | novel | c.1148N>T | p.Ala383Val | p.A383V | P56270 | protein_coding | deleterious(0) | possibly_damaging(0.818) | TCGA-AP-A0LS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAZ | SNV | Missense_Mutation | rs765655408 | c.1342N>T | p.Arg448Trp | p.R448W | P56270 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-D1-A177-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MAZ | SNV | Missense_Mutation | c.1150N>T | p.His384Tyr | p.H384Y | P56270 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-D1-A17D-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
MAZ | SNV | Missense_Mutation | novel | c.1262N>A | p.Cys421Tyr | p.C421Y | P56270 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EY-A1GO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
MAZ | deletion | Frame_Shift_Del | rs769505112 | c.1425delN | p.Ala478ProfsTer47 | p.A478Pfs*47 | P56270 | protein_coding | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MAZ | deletion | Frame_Shift_Del | c.1424delN | p.Leu475ArgfsTer50 | p.L475Rfs*50 | P56270 | protein_coding | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
MAZ | SNV | Missense_Mutation | c.1255C>T | p.His419Tyr | p.H419Y | P56270 | protein_coding | tolerated(0.09) | benign(0.106) | TCGA-BC-A10Y-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4150 | MAZ | TRANSCRIPTION FACTOR | IL-1 | 11809795 |
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