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Gene: MARCH11 |
Gene summary for MARCH11 |
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Gene information | Species | Human | Gene symbol | MARCH11 | Gene ID | 441061 |
Gene name | membrane associated ring-CH-type finger 11 | |
Gene Alias | MARCH-XI | |
Cytomap | 5p15.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A6NNE9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
441061 | MARCH11 | S014 | Human | Liver | HCC | 5.79e-11 | 5.06e-01 | 0.2254 |
441061 | MARCH11 | S015 | Human | Liver | HCC | 1.42e-09 | 3.41e-01 | 0.2375 |
441061 | MARCH11 | S016 | Human | Liver | HCC | 5.38e-24 | 6.77e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MARCH11 | SNV | Missense_Mutation | rs781465967 | c.1175N>T | p.Ser392Leu | p.S392L | A6NNE9 | protein_coding | deleterious(0) | possibly_damaging(0.511) | TCGA-CL-5917-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MARCH11 | SNV | Missense_Mutation | c.905N>A | p.Gly302Glu | p.G302E | A6NNE9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MARCH11 | deletion | Frame_Shift_Del | novel | c.1089delN | p.Ser364HisfsTer17 | p.S364Hfs*17 | A6NNE9 | protein_coding | TCGA-AA-A00O-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
MARCH11 | insertion | Nonsense_Mutation | novel | c.912_913insCCTTGGTGAG | p.Val305ProfsTer3 | p.V305Pfs*3 | A6NNE9 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MARCH11 | SNV | Missense_Mutation | novel | c.734N>C | p.Met245Thr | p.M245T | A6NNE9 | protein_coding | deleterious(0.04) | benign(0.024) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MARCH11 | SNV | Missense_Mutation | rs149078493 | c.1055N>A | p.Arg352Gln | p.R352Q | A6NNE9 | protein_coding | tolerated(0.09) | possibly_damaging(0.49) | TCGA-AJ-A5DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MARCH11 | SNV | Missense_Mutation | c.908N>A | p.Ala303Asp | p.A303D | A6NNE9 | protein_coding | deleterious(0.01) | possibly_damaging(0.694) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MARCH11 | SNV | Missense_Mutation | novel | c.556N>C | p.Cys186Arg | p.C186R | A6NNE9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MARCH11 | SNV | Missense_Mutation | novel | c.811N>A | p.Ala271Thr | p.A271T | A6NNE9 | protein_coding | tolerated(0.05) | probably_damaging(0.999) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MARCH11 | SNV | Missense_Mutation | c.835N>A | p.Leu279Ile | p.L279I | A6NNE9 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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