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Gene: MAPK8IP1 |
Gene summary for MAPK8IP1 |
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Gene information | Species | Human | Gene symbol | MAPK8IP1 | Gene ID | 9479 |
Gene name | mitogen-activated protein kinase 8 interacting protein 1 | |
Gene Alias | IB1 | |
Cytomap | 11p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q6NUQ9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9479 | MAPK8IP1 | HCC1_Meng | Human | Liver | HCC | 1.12e-02 | -8.60e-03 | 0.0246 |
9479 | MAPK8IP1 | HCC2 | Human | Liver | HCC | 7.12e-10 | 2.06e+00 | 0.5341 |
9479 | MAPK8IP1 | S014 | Human | Liver | HCC | 9.08e-10 | 3.71e-01 | 0.2254 |
9479 | MAPK8IP1 | S015 | Human | Liver | HCC | 2.82e-06 | 3.21e-01 | 0.2375 |
9479 | MAPK8IP1 | S016 | Human | Liver | HCC | 3.92e-17 | 5.12e-01 | 0.2243 |
9479 | MAPK8IP1 | S028 | Human | Liver | HCC | 2.52e-06 | 3.12e-01 | 0.2503 |
9479 | MAPK8IP1 | S029 | Human | Liver | HCC | 3.31e-04 | 2.32e-01 | 0.2581 |
9479 | MAPK8IP1 | PTC06 | Human | Thyroid | PTC | 2.51e-02 | 7.67e-02 | 0.2057 |
9479 | MAPK8IP1 | PTC07 | Human | Thyroid | PTC | 2.72e-06 | 6.83e-02 | 0.2044 |
9479 | MAPK8IP1 | ATC09 | Human | Thyroid | ATC | 1.17e-08 | 3.51e-01 | 0.2871 |
9479 | MAPK8IP1 | ATC13 | Human | Thyroid | ATC | 1.48e-33 | 5.04e-01 | 0.34 |
9479 | MAPK8IP1 | ATC1 | Human | Thyroid | ATC | 4.24e-08 | 3.94e-01 | 0.2878 |
9479 | MAPK8IP1 | ATC4 | Human | Thyroid | ATC | 2.03e-07 | 7.79e-02 | 0.34 |
9479 | MAPK8IP1 | ATC5 | Human | Thyroid | ATC | 6.99e-29 | 5.47e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200123322 | Liver | HCC | regulation of apoptotic signaling pathway | 226/7958 | 356/18723 | 7.26e-16 | 5.68e-14 | 226 |
GO:009719322 | Liver | HCC | intrinsic apoptotic signaling pathway | 184/7958 | 288/18723 | 1.50e-13 | 8.32e-12 | 184 |
GO:001056322 | Liver | HCC | negative regulation of phosphorus metabolic process | 259/7958 | 442/18723 | 4.29e-12 | 1.92e-10 | 259 |
GO:004593622 | Liver | HCC | negative regulation of phosphate metabolic process | 258/7958 | 441/18723 | 6.00e-12 | 2.60e-10 | 258 |
GO:200123412 | Liver | HCC | negative regulation of apoptotic signaling pathway | 145/7958 | 224/18723 | 1.33e-11 | 5.36e-10 | 145 |
GO:004232622 | Liver | HCC | negative regulation of phosphorylation | 227/7958 | 385/18723 | 3.98e-11 | 1.52e-09 | 227 |
GO:005134822 | Liver | HCC | negative regulation of transferase activity | 166/7958 | 268/18723 | 8.97e-11 | 3.18e-09 | 166 |
GO:200124212 | Liver | HCC | regulation of intrinsic apoptotic signaling pathway | 109/7958 | 164/18723 | 4.52e-10 | 1.45e-08 | 109 |
GO:003367322 | Liver | HCC | negative regulation of kinase activity | 144/7958 | 237/18723 | 9.76e-09 | 2.45e-07 | 144 |
GO:000193322 | Liver | HCC | negative regulation of protein phosphorylation | 196/7958 | 342/18723 | 1.95e-08 | 4.63e-07 | 196 |
GO:200124312 | Liver | HCC | negative regulation of intrinsic apoptotic signaling pathway | 67/7958 | 98/18723 | 1.97e-07 | 3.55e-06 | 67 |
GO:000646912 | Liver | HCC | negative regulation of protein kinase activity | 126/7958 | 212/18723 | 4.55e-07 | 7.49e-06 | 126 |
GO:003109822 | Liver | HCC | stress-activated protein kinase signaling cascade | 138/7958 | 247/18723 | 1.43e-05 | 1.57e-04 | 138 |
GO:005140322 | Liver | HCC | stress-activated MAPK cascade | 134/7958 | 239/18723 | 1.50e-05 | 1.64e-04 | 134 |
GO:007190021 | Liver | HCC | regulation of protein serine/threonine kinase activity | 189/7958 | 359/18723 | 5.97e-05 | 5.47e-04 | 189 |
GO:00434097 | Liver | HCC | negative regulation of MAPK cascade | 98/7958 | 180/18723 | 7.88e-04 | 4.74e-03 | 98 |
GO:007030222 | Liver | HCC | regulation of stress-activated protein kinase signaling cascade | 105/7958 | 195/18723 | 8.79e-04 | 5.20e-03 | 105 |
GO:003287312 | Liver | HCC | negative regulation of stress-activated MAPK cascade | 33/7958 | 51/18723 | 1.13e-03 | 6.44e-03 | 33 |
GO:007030312 | Liver | HCC | negative regulation of stress-activated protein kinase signaling cascade | 33/7958 | 51/18723 | 1.13e-03 | 6.44e-03 | 33 |
GO:003287222 | Liver | HCC | regulation of stress-activated MAPK cascade | 102/7958 | 192/18723 | 1.86e-03 | 9.49e-03 | 102 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAPK8IP1 | SNV | Missense_Mutation | c.1630N>A | p.Ala544Thr | p.A544T | Q9UQF2 | protein_coding | deleterious(0.04) | possibly_damaging(0.849) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAPK8IP1 | SNV | Missense_Mutation | rs749687015 | c.970C>T | p.Arg324Trp | p.R324W | Q9UQF2 | protein_coding | deleterious(0) | possibly_damaging(0.723) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MAPK8IP1 | SNV | Missense_Mutation | c.1781N>T | p.Ala594Val | p.A594V | Q9UQF2 | protein_coding | tolerated(0.16) | possibly_damaging(0.842) | TCGA-CA-6715-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
MAPK8IP1 | SNV | Missense_Mutation | c.1956G>T | p.Lys652Asn | p.K652N | Q9UQF2 | protein_coding | deleterious(0.03) | possibly_damaging(0.846) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
MAPK8IP1 | SNV | Missense_Mutation | c.875C>T | p.Ala292Val | p.A292V | Q9UQF2 | protein_coding | deleterious(0.01) | benign(0.001) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
MAPK8IP1 | SNV | Missense_Mutation | rs572233757 | c.1403G>A | p.Arg468His | p.R468H | Q9UQF2 | protein_coding | tolerated(0.08) | possibly_damaging(0.629) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MAPK8IP1 | SNV | Missense_Mutation | rs375735836 | c.1306C>T | p.Arg436Trp | p.R436W | Q9UQF2 | protein_coding | deleterious(0.01) | possibly_damaging(0.634) | TCGA-DM-A288-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
MAPK8IP1 | SNV | Missense_Mutation | novel | c.1516G>A | p.Glu506Lys | p.E506K | Q9UQF2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
MAPK8IP1 | SNV | Missense_Mutation | rs771448062 | c.917G>A | p.Arg306Gln | p.R306Q | Q9UQF2 | protein_coding | tolerated(0.08) | probably_damaging(0.992) | TCGA-F5-6571-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | capecitabine | SD |
MAPK8IP1 | deletion | Frame_Shift_Del | c.1923delN | p.Asn643ThrfsTer91 | p.N643Tfs*91 | Q9UQF2 | protein_coding | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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