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Gene: MAP1LC3A |
Gene summary for MAP1LC3A |
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Gene information | Species | Human | Gene symbol | MAP1LC3A | Gene ID | 84557 |
Gene name | microtubule associated protein 1 light chain 3 alpha | |
Gene Alias | ATG8E | |
Cytomap | 20q11.22 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q9H492 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84557 | MAP1LC3A | AEH-subject1 | Human | Endometrium | AEH | 4.03e-09 | -3.54e-01 | -0.3059 |
84557 | MAP1LC3A | AEH-subject2 | Human | Endometrium | AEH | 2.16e-05 | -3.33e-01 | -0.2525 |
84557 | MAP1LC3A | AEH-subject3 | Human | Endometrium | AEH | 1.15e-12 | -3.35e-01 | -0.2576 |
84557 | MAP1LC3A | AEH-subject4 | Human | Endometrium | AEH | 2.11e-07 | -4.01e-01 | -0.2657 |
84557 | MAP1LC3A | AEH-subject5 | Human | Endometrium | AEH | 1.19e-07 | -3.47e-01 | -0.2953 |
84557 | MAP1LC3A | EEC-subject1 | Human | Endometrium | EEC | 4.73e-15 | -4.04e-01 | -0.2682 |
84557 | MAP1LC3A | EEC-subject2 | Human | Endometrium | EEC | 8.41e-15 | -3.50e-01 | -0.2607 |
84557 | MAP1LC3A | EEC-subject3 | Human | Endometrium | EEC | 9.29e-39 | -4.83e-01 | -0.2525 |
84557 | MAP1LC3A | EEC-subject4 | Human | Endometrium | EEC | 2.68e-11 | -3.95e-01 | -0.2571 |
84557 | MAP1LC3A | EEC-subject5 | Human | Endometrium | EEC | 4.89e-03 | -2.71e-01 | -0.249 |
84557 | MAP1LC3A | GSM5276934 | Human | Endometrium | EEC | 4.33e-02 | -1.48e-01 | -0.0913 |
84557 | MAP1LC3A | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.55e-28 | -5.49e-01 | -0.1869 |
84557 | MAP1LC3A | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.06e-27 | -5.08e-01 | -0.1875 |
84557 | MAP1LC3A | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.66e-28 | -5.27e-01 | -0.1883 |
84557 | MAP1LC3A | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 5.58e-36 | -5.27e-01 | -0.1934 |
84557 | MAP1LC3A | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.40e-39 | -5.09e-01 | -0.1917 |
84557 | MAP1LC3A | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.47e-39 | -5.31e-01 | -0.1916 |
84557 | MAP1LC3A | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 2.27e-05 | -2.19e-01 | -0.1269 |
84557 | MAP1LC3A | LZE4T | Human | Esophagus | ESCC | 1.41e-12 | 3.93e-01 | 0.0811 |
84557 | MAP1LC3A | LZE20T | Human | Esophagus | ESCC | 4.86e-02 | 2.26e-02 | 0.0662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000697916 | Endometrium | AEH | response to oxidative stress | 93/2100 | 446/18723 | 1.94e-09 | 1.64e-07 | 93 |
GO:000030216 | Endometrium | AEH | response to reactive oxygen species | 54/2100 | 222/18723 | 2.54e-08 | 1.49e-06 | 54 |
GO:006219716 | Endometrium | AEH | cellular response to chemical stress | 71/2100 | 337/18723 | 1.03e-07 | 5.05e-06 | 71 |
GO:004254215 | Endometrium | AEH | response to hydrogen peroxide | 38/2100 | 146/18723 | 4.70e-07 | 1.92e-05 | 38 |
GO:00004228 | Endometrium | AEH | autophagy of mitochondrion | 24/2100 | 81/18723 | 5.41e-06 | 1.36e-04 | 24 |
GO:00617268 | Endometrium | AEH | mitochondrion disassembly | 24/2100 | 81/18723 | 5.41e-06 | 1.36e-04 | 24 |
GO:003459916 | Endometrium | AEH | cellular response to oxidative stress | 58/2100 | 288/18723 | 6.49e-06 | 1.58e-04 | 58 |
GO:002241115 | Endometrium | AEH | cellular component disassembly | 80/2100 | 443/18723 | 1.07e-05 | 2.45e-04 | 80 |
GO:19030086 | Endometrium | AEH | organelle disassembly | 29/2100 | 114/18723 | 1.66e-05 | 3.43e-04 | 29 |
GO:00329848 | Endometrium | AEH | protein-containing complex disassembly | 45/2100 | 224/18723 | 7.16e-05 | 1.10e-03 | 45 |
GO:003461415 | Endometrium | AEH | cellular response to reactive oxygen species | 34/2100 | 155/18723 | 9.00e-05 | 1.30e-03 | 34 |
GO:001003816 | Endometrium | AEH | response to metal ion | 65/2100 | 373/18723 | 2.02e-04 | 2.54e-03 | 65 |
GO:007149616 | Endometrium | AEH | cellular response to external stimulus | 57/2100 | 320/18723 | 2.72e-04 | 3.14e-03 | 57 |
GO:003166716 | Endometrium | AEH | response to nutrient levels | 78/2100 | 474/18723 | 3.26e-04 | 3.64e-03 | 78 |
GO:00162368 | Endometrium | AEH | macroautophagy | 52/2100 | 291/18723 | 4.56e-04 | 4.80e-03 | 52 |
GO:00092679 | Endometrium | AEH | cellular response to starvation | 31/2100 | 156/18723 | 1.08e-03 | 9.46e-03 | 31 |
GO:00316699 | Endometrium | AEH | cellular response to nutrient levels | 39/2100 | 215/18723 | 1.66e-03 | 1.36e-02 | 39 |
GO:003166810 | Endometrium | AEH | cellular response to extracellular stimulus | 43/2100 | 246/18723 | 2.10e-03 | 1.63e-02 | 43 |
GO:00425949 | Endometrium | AEH | response to starvation | 36/2100 | 197/18723 | 2.15e-03 | 1.65e-02 | 36 |
GO:00703015 | Endometrium | AEH | cellular response to hydrogen peroxide | 20/2100 | 98/18723 | 5.64e-03 | 3.46e-02 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501420 | Endometrium | AEH | Amyotrophic lateral sclerosis | 123/1197 | 364/8465 | 2.17e-22 | 7.82e-21 | 5.72e-21 | 123 |
hsa0502220 | Endometrium | AEH | Pathways of neurodegeneration - multiple diseases | 137/1197 | 476/8465 | 9.27e-18 | 2.32e-16 | 1.70e-16 | 137 |
hsa0513126 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa0421616 | Endometrium | AEH | Ferroptosis | 15/1197 | 41/8465 | 2.83e-04 | 2.30e-03 | 1.68e-03 | 15 |
hsa0413720 | Endometrium | AEH | Mitophagy - animal | 21/1197 | 72/8465 | 7.03e-04 | 4.86e-03 | 3.56e-03 | 21 |
hsa0516725 | Endometrium | AEH | Kaposi sarcoma-associated herpesvirus infection | 44/1197 | 194/8465 | 7.97e-04 | 5.28e-03 | 3.87e-03 | 44 |
hsa05014110 | Endometrium | AEH | Amyotrophic lateral sclerosis | 123/1197 | 364/8465 | 2.17e-22 | 7.82e-21 | 5.72e-21 | 123 |
hsa05022110 | Endometrium | AEH | Pathways of neurodegeneration - multiple diseases | 137/1197 | 476/8465 | 9.27e-18 | 2.32e-16 | 1.70e-16 | 137 |
hsa05131111 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa0421617 | Endometrium | AEH | Ferroptosis | 15/1197 | 41/8465 | 2.83e-04 | 2.30e-03 | 1.68e-03 | 15 |
hsa04137110 | Endometrium | AEH | Mitophagy - animal | 21/1197 | 72/8465 | 7.03e-04 | 4.86e-03 | 3.56e-03 | 21 |
hsa05167111 | Endometrium | AEH | Kaposi sarcoma-associated herpesvirus infection | 44/1197 | 194/8465 | 7.97e-04 | 5.28e-03 | 3.87e-03 | 44 |
hsa0501425 | Endometrium | EEC | Amyotrophic lateral sclerosis | 128/1237 | 364/8465 | 9.83e-24 | 4.04e-22 | 3.01e-22 | 128 |
hsa0502225 | Endometrium | EEC | Pathways of neurodegeneration - multiple diseases | 140/1237 | 476/8465 | 9.49e-18 | 2.60e-16 | 1.94e-16 | 140 |
hsa0513127 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
hsa0421625 | Endometrium | EEC | Ferroptosis | 16/1237 | 41/8465 | 1.09e-04 | 1.08e-03 | 8.08e-04 | 16 |
hsa0413725 | Endometrium | EEC | Mitophagy - animal | 22/1237 | 72/8465 | 4.12e-04 | 3.30e-03 | 2.46e-03 | 22 |
hsa0516726 | Endometrium | EEC | Kaposi sarcoma-associated herpesvirus infection | 45/1237 | 194/8465 | 8.55e-04 | 5.86e-03 | 4.37e-03 | 45 |
hsa0501435 | Endometrium | EEC | Amyotrophic lateral sclerosis | 128/1237 | 364/8465 | 9.83e-24 | 4.04e-22 | 3.01e-22 | 128 |
hsa0502235 | Endometrium | EEC | Pathways of neurodegeneration - multiple diseases | 140/1237 | 476/8465 | 9.49e-18 | 2.60e-16 | 1.94e-16 | 140 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAP1LC3A | SNV | Missense_Mutation | c.170N>C | p.Leu57Ser | p.L57S | Q9H492 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAP1LC3A | SNV | Missense_Mutation | novel | c.35A>G | p.Lys12Arg | p.K12R | Q9H492 | protein_coding | tolerated(0.55) | benign(0.017) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAP1LC3A | SNV | Missense_Mutation | novel | c.15C>A | p.Phe5Leu | p.F5L | Q9H492 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MAP1LC3A | SNV | Missense_Mutation | novel | c.152N>A | p.Leu51Gln | p.L51Q | Q9H492 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-DD-AACI-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MAP1LC3A | SNV | Missense_Mutation | novel | c.178G>C | p.Asp60His | p.D60H | Q9H492 | protein_coding | tolerated(0.06) | probably_damaging(0.999) | TCGA-44-A47F-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | alimta | CR |
MAP1LC3A | SNV | Missense_Mutation | novel | c.179A>C | p.Asp60Ala | p.D60A | Q9H492 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-44-A47F-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | alimta | CR |
MAP1LC3A | SNV | Missense_Mutation | c.196N>A | p.Glu66Lys | p.E66K | Q9H492 | protein_coding | tolerated(0.07) | probably_damaging(0.973) | TCGA-CQ-7063-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
MAP1LC3A | SNV | Missense_Mutation | c.221N>A | p.Arg74His | p.R74H | Q9H492 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MAP1LC3A | SNV | Missense_Mutation | c.221G>A | p.Arg74His | p.R74H | Q9H492 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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