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Gene: MAN2C1 |
Gene summary for MAN2C1 |
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Gene information | Species | Human | Gene symbol | MAN2C1 | Gene ID | 4123 |
Gene name | mannosidase alpha class 2C member 1 | |
Gene Alias | MAN6A8 | |
Cytomap | 15q24.2 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q9NTJ4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4123 | MAN2C1 | LZE2T | Human | Esophagus | ESCC | 3.98e-05 | 4.89e-01 | 0.082 |
4123 | MAN2C1 | LZE4T | Human | Esophagus | ESCC | 3.93e-02 | 1.10e-01 | 0.0811 |
4123 | MAN2C1 | LZE7T | Human | Esophagus | ESCC | 2.11e-03 | 2.11e-01 | 0.0667 |
4123 | MAN2C1 | LZE8T | Human | Esophagus | ESCC | 1.38e-03 | 1.06e-01 | 0.067 |
4123 | MAN2C1 | LZE24T | Human | Esophagus | ESCC | 6.82e-05 | 1.12e-01 | 0.0596 |
4123 | MAN2C1 | P1T-E | Human | Esophagus | ESCC | 2.03e-05 | 2.92e-01 | 0.0875 |
4123 | MAN2C1 | P2T-E | Human | Esophagus | ESCC | 5.94e-14 | 1.70e-01 | 0.1177 |
4123 | MAN2C1 | P4T-E | Human | Esophagus | ESCC | 9.27e-09 | 1.69e-01 | 0.1323 |
4123 | MAN2C1 | P5T-E | Human | Esophagus | ESCC | 6.92e-09 | 7.32e-03 | 0.1327 |
4123 | MAN2C1 | P8T-E | Human | Esophagus | ESCC | 9.32e-14 | 2.91e-01 | 0.0889 |
4123 | MAN2C1 | P9T-E | Human | Esophagus | ESCC | 7.12e-08 | 1.80e-01 | 0.1131 |
4123 | MAN2C1 | P10T-E | Human | Esophagus | ESCC | 1.02e-24 | 2.07e-01 | 0.116 |
4123 | MAN2C1 | P12T-E | Human | Esophagus | ESCC | 6.79e-18 | 2.28e-01 | 0.1122 |
4123 | MAN2C1 | P15T-E | Human | Esophagus | ESCC | 8.96e-14 | 3.08e-01 | 0.1149 |
4123 | MAN2C1 | P16T-E | Human | Esophagus | ESCC | 2.81e-22 | 3.89e-01 | 0.1153 |
4123 | MAN2C1 | P17T-E | Human | Esophagus | ESCC | 2.93e-02 | 2.12e-01 | 0.1278 |
4123 | MAN2C1 | P20T-E | Human | Esophagus | ESCC | 4.33e-13 | 2.46e-01 | 0.1124 |
4123 | MAN2C1 | P21T-E | Human | Esophagus | ESCC | 1.10e-09 | 6.35e-02 | 0.1617 |
4123 | MAN2C1 | P22T-E | Human | Esophagus | ESCC | 4.05e-15 | 1.72e-01 | 0.1236 |
4123 | MAN2C1 | P23T-E | Human | Esophagus | ESCC | 8.74e-07 | 1.56e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00059969 | Esophagus | ESCC | monosaccharide metabolic process | 159/8552 | 257/18723 | 1.11e-07 | 1.81e-06 | 159 |
GO:00193189 | Esophagus | ESCC | hexose metabolic process | 147/8552 | 237/18723 | 2.63e-07 | 3.94e-06 | 147 |
GO:001605216 | Esophagus | ESCC | carbohydrate catabolic process | 91/8552 | 154/18723 | 5.39e-04 | 2.97e-03 | 91 |
GO:000599621 | Liver | HCC | monosaccharide metabolic process | 167/7958 | 257/18723 | 2.31e-13 | 1.25e-11 | 167 |
GO:001931821 | Liver | HCC | hexose metabolic process | 155/7958 | 237/18723 | 7.63e-13 | 3.90e-11 | 155 |
GO:001605222 | Liver | HCC | carbohydrate catabolic process | 99/7958 | 154/18723 | 3.79e-08 | 8.30e-07 | 99 |
GO:00059968 | Oral cavity | OSCC | monosaccharide metabolic process | 129/7305 | 257/18723 | 1.63e-04 | 1.13e-03 | 129 |
GO:00193188 | Oral cavity | OSCC | hexose metabolic process | 118/7305 | 237/18723 | 4.53e-04 | 2.73e-03 | 118 |
GO:001605210 | Oral cavity | OSCC | carbohydrate catabolic process | 76/7305 | 154/18723 | 5.67e-03 | 2.18e-02 | 76 |
GO:000599613 | Oral cavity | LP | monosaccharide metabolic process | 86/4623 | 257/18723 | 9.13e-04 | 7.79e-03 | 86 |
GO:001931813 | Oral cavity | LP | hexose metabolic process | 78/4623 | 237/18723 | 2.55e-03 | 1.80e-02 | 78 |
GO:001605215 | Oral cavity | LP | carbohydrate catabolic process | 53/4623 | 154/18723 | 4.22e-03 | 2.70e-02 | 53 |
GO:001931810 | Thyroid | PTC | hexose metabolic process | 108/5968 | 237/18723 | 6.42e-06 | 7.65e-05 | 108 |
GO:000599614 | Thyroid | PTC | monosaccharide metabolic process | 115/5968 | 257/18723 | 9.36e-06 | 1.05e-04 | 115 |
GO:001605218 | Thyroid | PTC | carbohydrate catabolic process | 70/5968 | 154/18723 | 2.77e-04 | 1.97e-03 | 70 |
GO:001931814 | Thyroid | ATC | hexose metabolic process | 111/6293 | 237/18723 | 1.51e-05 | 1.41e-04 | 111 |
GO:000599615 | Thyroid | ATC | monosaccharide metabolic process | 118/6293 | 257/18723 | 2.56e-05 | 2.20e-04 | 118 |
GO:001605224 | Thyroid | ATC | carbohydrate catabolic process | 71/6293 | 154/18723 | 8.33e-04 | 4.57e-03 | 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00511 | Liver | HCC | Other glycan degradation | 15/4020 | 18/8465 | 1.96e-03 | 6.91e-03 | 3.84e-03 | 15 |
hsa005111 | Liver | HCC | Other glycan degradation | 15/4020 | 18/8465 | 1.96e-03 | 6.91e-03 | 3.84e-03 | 15 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAN2C1 | SNV | Missense_Mutation | rs748277033 | c.1879N>A | p.Val627Ile | p.V627I | Q9NTJ4 | protein_coding | tolerated(0.38) | benign(0.012) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MAN2C1 | SNV | Missense_Mutation | rs753112818 | c.848N>T | p.Ala283Val | p.A283V | Q9NTJ4 | protein_coding | tolerated(1) | benign(0.005) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MAN2C1 | SNV | Missense_Mutation | novel | c.2191A>G | p.Arg731Gly | p.R731G | Q9NTJ4 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AF-3913-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | xeloda | PD |
MAN2C1 | SNV | Missense_Mutation | rs754290709 | c.2939C>T | p.Ala980Val | p.A980V | Q9NTJ4 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-AF-6136-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
MAN2C1 | SNV | Missense_Mutation | c.164N>T | p.Pro55Leu | p.P55L | Q9NTJ4 | protein_coding | deleterious(0) | benign(0.037) | TCGA-EI-6508-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
MAN2C1 | SNV | Missense_Mutation | novel | c.449N>A | p.Cys150Tyr | p.C150Y | Q9NTJ4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MAN2C1 | SNV | Missense_Mutation | rs767342082 | c.3151G>A | p.Val1051Met | p.V1051M | Q9NTJ4 | protein_coding | deleterious(0.04) | benign(0.078) | TCGA-A5-A0GV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MAN2C1 | SNV | Missense_Mutation | novel | c.2158N>T | p.Arg720Cys | p.R720C | Q9NTJ4 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAN2C1 | SNV | Missense_Mutation | novel | c.2071N>C | p.Ser691Pro | p.S691P | Q9NTJ4 | protein_coding | tolerated(0.34) | benign(0.078) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAN2C1 | SNV | Missense_Mutation | rs768526490 | c.2717C>T | p.Ala906Val | p.A906V | Q9NTJ4 | protein_coding | deleterious(0) | possibly_damaging(0.698) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4123 | MAN2C1 | DRUGGABLE GENOME | M-0011 |
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