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Gene: MAGEB10 |
Gene summary for MAGEB10 |
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Gene information | Species | Human | Gene symbol | MAGEB10 | Gene ID | 139422 |
Gene name | MAGE family member B10 | |
Gene Alias | MAGEB10 | |
Cytomap | Xp21.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q96LZ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
139422 | MAGEB10 | HCC1 | Human | Liver | HCC | 7.19e-14 | 9.30e-01 | 0.5336 |
139422 | MAGEB10 | HCC2 | Human | Liver | HCC | 1.12e-12 | 6.89e-01 | 0.5341 |
139422 | MAGEB10 | HCC5 | Human | Liver | HCC | 1.75e-08 | 8.45e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAGEB10 | SNV | Missense_Mutation | novel | c.727N>A | p.Glu243Lys | p.E243K | Q96LZ2 | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MAGEB10 | SNV | Missense_Mutation | novel | c.501C>A | p.Asp167Glu | p.D167E | Q96LZ2 | protein_coding | tolerated(0.19) | possibly_damaging(0.865) | TCGA-ZJ-AAXB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MAGEB10 | SNV | Missense_Mutation | c.462N>A | p.Ser154Arg | p.S154R | Q96LZ2 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AA-3861-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MAGEB10 | SNV | Missense_Mutation | novel | c.512N>A | p.Val171Glu | p.V171E | Q96LZ2 | protein_coding | deleterious(0.02) | probably_damaging(0.977) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAGEB10 | SNV | Missense_Mutation | rs765296675 | c.909N>A | p.Phe303Leu | p.F303L | Q96LZ2 | protein_coding | deleterious(0.05) | possibly_damaging(0.62) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MAGEB10 | SNV | Missense_Mutation | rs529513171 | c.299N>G | p.Leu100Arg | p.L100R | Q96LZ2 | protein_coding | tolerated(0.54) | benign(0.001) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MAGEB10 | SNV | Missense_Mutation | c.858N>T | p.Met286Ile | p.M286I | Q96LZ2 | protein_coding | deleterious(0.02) | probably_damaging(0.934) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MAGEB10 | SNV | Missense_Mutation | c.602C>G | p.Thr201Ser | p.T201S | Q96LZ2 | protein_coding | tolerated(0.06) | benign(0.351) | TCGA-F5-6861-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAGEB10 | SNV | Missense_Mutation | c.703G>A | p.Gly235Arg | p.G235R | Q96LZ2 | protein_coding | deleterious(0.02) | possibly_damaging(0.881) | TCGA-A5-A0G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAGEB10 | SNV | Missense_Mutation | c.499N>T | p.Asp167Tyr | p.D167Y | Q96LZ2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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