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Gene: LRRFIP1 |
Gene summary for LRRFIP1 |
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Gene information | Species | Human | Gene symbol | LRRFIP1 | Gene ID | 9208 |
Gene name | LRR binding FLII interacting protein 1 | |
Gene Alias | FLAP-1 | |
Cytomap | 2q37.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q32MZ4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9208 | LRRFIP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.30e-04 | -2.53e-01 | 0.0155 |
9208 | LRRFIP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.14e-04 | 6.46e-01 | -0.1808 |
9208 | LRRFIP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.62e-12 | 8.18e-01 | -0.0811 |
9208 | LRRFIP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.06e-04 | 5.49e-01 | -0.1088 |
9208 | LRRFIP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.33e-25 | 9.23e-01 | -0.1954 |
9208 | LRRFIP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.35e-10 | 1.43e+00 | -0.2602 |
9208 | LRRFIP1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.31e-11 | 1.04e+00 | -0.2196 |
9208 | LRRFIP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.24e-08 | 6.11e-01 | -0.1464 |
9208 | LRRFIP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.85e-08 | 8.03e-01 | -0.059 |
9208 | LRRFIP1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.68e-10 | 8.79e-01 | 0.281 |
9208 | LRRFIP1 | F007 | Human | Colorectum | FAP | 3.41e-04 | -4.15e-01 | 0.1176 |
9208 | LRRFIP1 | A002-C-010 | Human | Colorectum | FAP | 1.97e-03 | -3.00e-01 | 0.242 |
9208 | LRRFIP1 | A001-C-207 | Human | Colorectum | FAP | 1.06e-06 | -4.02e-01 | 0.1278 |
9208 | LRRFIP1 | A015-C-203 | Human | Colorectum | FAP | 3.00e-31 | -4.12e-01 | -0.1294 |
9208 | LRRFIP1 | A015-C-204 | Human | Colorectum | FAP | 1.48e-08 | -3.65e-01 | -0.0228 |
9208 | LRRFIP1 | A014-C-040 | Human | Colorectum | FAP | 1.64e-05 | -3.45e-01 | -0.1184 |
9208 | LRRFIP1 | A002-C-201 | Human | Colorectum | FAP | 5.56e-17 | -4.15e-01 | 0.0324 |
9208 | LRRFIP1 | A002-C-203 | Human | Colorectum | FAP | 1.29e-03 | -2.88e-01 | 0.2786 |
9208 | LRRFIP1 | A001-C-119 | Human | Colorectum | FAP | 7.84e-04 | -1.48e-01 | -0.1557 |
9208 | LRRFIP1 | A001-C-108 | Human | Colorectum | FAP | 3.37e-16 | -2.59e-01 | -0.0272 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRFIP1 | SNV | Missense_Mutation | c.448N>C | p.Glu150Gln | p.E150Q | Q32MZ4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
LRRFIP1 | SNV | Missense_Mutation | c.946N>C | p.Glu316Gln | p.E316Q | Q32MZ4 | protein_coding | deleterious(0.04) | possibly_damaging(0.856) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
LRRFIP1 | SNV | Missense_Mutation | rs371410588 | c.167N>A | p.Arg56His | p.R56H | Q32MZ4 | protein_coding | deleterious(0) | benign(0.019) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
LRRFIP1 | SNV | Missense_Mutation | c.842N>T | p.Thr281Ile | p.T281I | Q32MZ4 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
LRRFIP1 | SNV | Missense_Mutation | rs201221434 | c.197N>T | p.Ser66Leu | p.S66L | Q32MZ4 | protein_coding | deleterious(0.01) | benign(0.284) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LRRFIP1 | SNV | Missense_Mutation | c.845A>C | p.Lys282Thr | p.K282T | Q32MZ4 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
LRRFIP1 | SNV | Missense_Mutation | rs760008859 | c.640N>A | p.Glu214Lys | p.E214K | Q32MZ4 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
LRRFIP1 | SNV | Missense_Mutation | c.1598C>T | p.Thr533Ile | p.T533I | Q32MZ4 | protein_coding | tolerated(0.09) | benign(0.006) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD | |
LRRFIP1 | SNV | Missense_Mutation | rs566068988 | c.2314N>A | p.Asp772Asn | p.D772N | Q32MZ4 | protein_coding | deleterious(0.04) | benign(0.006) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LRRFIP1 | SNV | Missense_Mutation | novel | c.1794N>T | p.Gln598His | p.Q598H | Q32MZ4 | protein_coding | deleterious(0.05) | benign(0.071) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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