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Gene: LRRC23 |
Gene summary for LRRC23 |
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Gene information | Species | Human | Gene symbol | LRRC23 | Gene ID | 10233 |
Gene name | leucine rich repeat containing 23 | |
Gene Alias | LRPB7 | |
Cytomap | 12p13.31 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A8K8K2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10233 | LRRC23 | AEH-subject1 | Human | Endometrium | AEH | 3.20e-15 | 5.94e-01 | -0.3059 |
10233 | LRRC23 | AEH-subject2 | Human | Endometrium | AEH | 1.46e-10 | 4.26e-01 | -0.2525 |
10233 | LRRC23 | AEH-subject3 | Human | Endometrium | AEH | 1.79e-14 | 5.79e-01 | -0.2576 |
10233 | LRRC23 | AEH-subject4 | Human | Endometrium | AEH | 1.91e-14 | 5.37e-01 | -0.2657 |
10233 | LRRC23 | AEH-subject5 | Human | Endometrium | AEH | 1.38e-03 | 3.17e-01 | -0.2953 |
10233 | LRRC23 | EEC-subject1 | Human | Endometrium | EEC | 1.06e-15 | 5.98e-01 | -0.2682 |
10233 | LRRC23 | EEC-subject4 | Human | Endometrium | EEC | 1.20e-09 | 4.77e-01 | -0.2571 |
10233 | LRRC23 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.80e-02 | -4.72e-02 | -0.1869 |
10233 | LRRC23 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 3.38e-03 | -5.33e-02 | -0.1875 |
10233 | LRRC23 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.77e-02 | 1.01e-01 | -0.1934 |
10233 | LRRC23 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 6.35e-10 | 1.40e-02 | -0.1917 |
10233 | LRRC23 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.79e-03 | -1.42e-03 | -0.1916 |
10233 | LRRC23 | LZE4T | Human | Esophagus | ESCC | 6.14e-04 | 1.50e-01 | 0.0811 |
10233 | LRRC23 | LZE8T | Human | Esophagus | ESCC | 1.33e-02 | 1.66e-01 | 0.067 |
10233 | LRRC23 | LZE24T | Human | Esophagus | ESCC | 5.64e-11 | 4.43e-01 | 0.0596 |
10233 | LRRC23 | P1T-E | Human | Esophagus | ESCC | 3.16e-06 | 2.65e-01 | 0.0875 |
10233 | LRRC23 | P2T-E | Human | Esophagus | ESCC | 2.08e-40 | 5.91e-01 | 0.1177 |
10233 | LRRC23 | P4T-E | Human | Esophagus | ESCC | 1.82e-20 | 4.08e-01 | 0.1323 |
10233 | LRRC23 | P5T-E | Human | Esophagus | ESCC | 3.60e-13 | 2.22e-01 | 0.1327 |
10233 | LRRC23 | P8T-E | Human | Esophagus | ESCC | 1.26e-05 | 1.45e-01 | 0.0889 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRC23 | SNV | Missense_Mutation | novel | c.1026N>T | p.Leu342Phe | p.L342F | Q53EV4 | protein_coding | tolerated_low_confidence(0.16) | benign(0.044) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
LRRC23 | SNV | Missense_Mutation | c.306N>A | p.His102Gln | p.H102Q | Q53EV4 | protein_coding | tolerated(0.17) | benign(0.082) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LRRC23 | SNV | Missense_Mutation | rs781833414 | c.1015G>A | p.Glu339Lys | p.E339K | Q53EV4 | protein_coding | tolerated_low_confidence(0.18) | benign(0.007) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
LRRC23 | deletion | Frame_Shift_Del | c.52_55delNNNN | p.Glu18LysfsTer34 | p.E18Kfs*34 | Q53EV4 | protein_coding | TCGA-CM-6677-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
LRRC23 | SNV | Missense_Mutation | rs782603047 | c.689G>A | p.Arg230Gln | p.R230Q | Q53EV4 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LRRC23 | SNV | Missense_Mutation | rs537212288 | c.1000N>T | p.Arg334Cys | p.R334C | Q53EV4 | protein_coding | tolerated_low_confidence(0.08) | benign(0.132) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
LRRC23 | SNV | Missense_Mutation | novel | c.98N>T | p.Arg33Ile | p.R33I | Q53EV4 | protein_coding | tolerated(0.05) | benign(0.28) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
LRRC23 | SNV | Missense_Mutation | rs782603047 | c.689G>A | p.Arg230Gln | p.R230Q | Q53EV4 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
LRRC23 | SNV | Missense_Mutation | novel | c.853N>A | p.Glu285Lys | p.E285K | Q53EV4 | protein_coding | tolerated(0.17) | benign(0.022) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LRRC23 | SNV | Missense_Mutation | rs781881095 | c.1001N>A | p.Arg334His | p.R334H | Q53EV4 | protein_coding | tolerated_low_confidence(0.51) | benign(0) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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