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Gene: LRRC17 |
Gene summary for LRRC17 |
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Gene information | Species | Human | Gene symbol | LRRC17 | Gene ID | 10234 |
Gene name | leucine rich repeat containing 17 | |
Gene Alias | P37NB | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q8N6Y2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10234 | LRRC17 | ATC13 | Human | Thyroid | ATC | 9.29e-82 | 1.79e+00 | 0.34 |
10234 | LRRC17 | ATC2 | Human | Thyroid | ATC | 3.82e-02 | 6.55e-01 | 0.34 |
10234 | LRRC17 | ATC5 | Human | Thyroid | ATC | 2.95e-82 | 1.88e+00 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:006034813 | Thyroid | ATC | bone development | 102/6293 | 205/18723 | 1.18e-06 | 1.52e-05 | 102 |
GO:003009933 | Thyroid | ATC | myeloid cell differentiation | 170/6293 | 381/18723 | 4.26e-06 | 4.68e-05 | 170 |
GO:1903706112 | Thyroid | ATC | regulation of hemopoiesis | 148/6293 | 367/18723 | 3.87e-03 | 1.68e-02 | 148 |
GO:0045637113 | Thyroid | ATC | regulation of myeloid cell differentiation | 89/6293 | 210/18723 | 4.75e-03 | 1.96e-02 | 89 |
GO:0002573110 | Thyroid | ATC | myeloid leukocyte differentiation | 86/6293 | 208/18723 | 1.15e-02 | 4.11e-02 | 86 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRC17 | SNV | Missense_Mutation | novel | c.675A>C | p.Gln225His | p.Q225H | Q8N6Y2 | protein_coding | tolerated(0.13) | benign(0.339) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
LRRC17 | SNV | Missense_Mutation | c.242A>G | p.Gln81Arg | p.Q81R | Q8N6Y2 | protein_coding | tolerated(0.47) | benign(0.003) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LRRC17 | SNV | Missense_Mutation | novel | c.450N>G | p.Ile150Met | p.I150M | Q8N6Y2 | protein_coding | deleterious(0.01) | possibly_damaging(0.671) | TCGA-T9-A92H-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
LRRC17 | SNV | Missense_Mutation | c.1012N>T | p.Asp338Tyr | p.D338Y | Q8N6Y2 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LRRC17 | SNV | Missense_Mutation | c.420G>C | p.Gln140His | p.Q140H | Q8N6Y2 | protein_coding | deleterious(0.03) | possibly_damaging(0.58) | TCGA-AG-3896-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LRRC17 | SNV | Missense_Mutation | novel | c.1204A>C | p.Lys402Gln | p.K402Q | Q8N6Y2 | protein_coding | deleterious(0.03) | benign(0.312) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LRRC17 | deletion | Frame_Shift_Del | rs769532305 | c.1265delN | p.Lys424AsnfsTer12 | p.K424Nfs*12 | Q8N6Y2 | protein_coding | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
LRRC17 | deletion | Frame_Shift_Del | rs769532305 | c.1272delA | p.Lys424AsnfsTer12 | p.K424Nfs*12 | Q8N6Y2 | protein_coding | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LRRC17 | deletion | Frame_Shift_Del | rs769532305 | c.1272delA | p.Lys424AsnfsTer12 | p.K424Nfs*12 | Q8N6Y2 | protein_coding | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LRRC17 | deletion | Frame_Shift_Del | rs769532305 | c.1265delN | p.Lys424AsnfsTer12 | p.K424Nfs*12 | Q8N6Y2 | protein_coding | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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