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Gene: LENG9 |
Gene summary for LENG9 |
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Gene information | Species | Human | Gene symbol | LENG9 | Gene ID | 94059 |
Gene name | leukocyte receptor cluster member 9 | |
Gene Alias | LENG9 | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A087WVD1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
94059 | LENG9 | LZE24T | Human | Esophagus | ESCC | 1.44e-13 | 3.89e-01 | 0.0596 |
94059 | LENG9 | LZE21T | Human | Esophagus | ESCC | 9.27e-04 | 2.40e-01 | 0.0655 |
94059 | LENG9 | P1T-E | Human | Esophagus | ESCC | 8.82e-20 | 9.07e-01 | 0.0875 |
94059 | LENG9 | P2T-E | Human | Esophagus | ESCC | 1.99e-07 | 1.46e-01 | 0.1177 |
94059 | LENG9 | P4T-E | Human | Esophagus | ESCC | 7.68e-05 | 8.76e-02 | 0.1323 |
94059 | LENG9 | P8T-E | Human | Esophagus | ESCC | 1.94e-15 | 2.77e-01 | 0.0889 |
94059 | LENG9 | P15T-E | Human | Esophagus | ESCC | 3.98e-05 | 1.09e-01 | 0.1149 |
94059 | LENG9 | P20T-E | Human | Esophagus | ESCC | 1.25e-03 | 1.26e-01 | 0.1124 |
94059 | LENG9 | P21T-E | Human | Esophagus | ESCC | 1.08e-05 | 1.25e-01 | 0.1617 |
94059 | LENG9 | P23T-E | Human | Esophagus | ESCC | 1.09e-13 | 3.49e-01 | 0.108 |
94059 | LENG9 | P24T-E | Human | Esophagus | ESCC | 5.06e-12 | 1.55e-01 | 0.1287 |
94059 | LENG9 | P26T-E | Human | Esophagus | ESCC | 2.85e-10 | 1.51e-01 | 0.1276 |
94059 | LENG9 | P28T-E | Human | Esophagus | ESCC | 2.06e-09 | 1.06e-01 | 0.1149 |
94059 | LENG9 | P31T-E | Human | Esophagus | ESCC | 1.37e-03 | 1.56e-01 | 0.1251 |
94059 | LENG9 | P32T-E | Human | Esophagus | ESCC | 5.74e-06 | 7.73e-02 | 0.1666 |
94059 | LENG9 | P36T-E | Human | Esophagus | ESCC | 1.09e-09 | 2.97e-01 | 0.1187 |
94059 | LENG9 | P37T-E | Human | Esophagus | ESCC | 2.21e-07 | 1.65e-01 | 0.1371 |
94059 | LENG9 | P39T-E | Human | Esophagus | ESCC | 2.18e-06 | 1.08e-01 | 0.0894 |
94059 | LENG9 | P42T-E | Human | Esophagus | ESCC | 4.69e-06 | 2.36e-01 | 0.1175 |
94059 | LENG9 | P44T-E | Human | Esophagus | ESCC | 1.73e-02 | 1.07e-01 | 0.1096 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LENG9 | SNV | Missense_Mutation | novel | c.1187T>C | p.Leu396Pro | p.L396P | protein_coding | tolerated(0.05) | benign(0.341) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LENG9 | SNV | Missense_Mutation | novel | c.948G>T | p.Lys316Asn | p.K316N | protein_coding | tolerated(0.06) | possibly_damaging(0.801) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LENG9 | SNV | Missense_Mutation | rs368668472 | c.887N>A | p.Arg296His | p.R296H | protein_coding | deleterious(0.02) | benign(0.009) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LENG9 | SNV | Missense_Mutation | rs757534030 | c.799N>A | p.Ala267Thr | p.A267T | protein_coding | tolerated(0.65) | benign(0) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LENG9 | SNV | Missense_Mutation | novel | c.1150G>A | p.Gly384Ser | p.G384S | protein_coding | tolerated(0.1) | probably_damaging(0.943) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LENG9 | SNV | Missense_Mutation | novel | c.430N>T | p.Leu144Phe | p.L144F | protein_coding | tolerated(0.7) | possibly_damaging(0.503) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LENG9 | SNV | Missense_Mutation | novel | c.1352N>A | p.Cys451Tyr | p.C451Y | protein_coding | deleterious(0.01) | benign(0.254) | TCGA-FI-A2D6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LENG9 | SNV | Missense_Mutation | rs542592473 | c.1154N>T | p.Pro385Leu | p.P385L | protein_coding | tolerated(0.27) | benign(0.369) | TCGA-PG-A917-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LENG9 | SNV | Missense_Mutation | novel | c.997N>A | p.Val333Met | p.V333M | protein_coding | tolerated(0.13) | probably_damaging(0.999) | TCGA-SL-A6JA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LENG9 | deletion | Frame_Shift_Del | novel | c.875delN | p.Pro292LeufsTer14 | p.P292Lfs*14 | protein_coding | TCGA-AX-A3G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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