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Gene: LECT2 |
Gene summary for LECT2 |
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Gene information | Species | Human | Gene symbol | LECT2 | Gene ID | 3950 |
Gene name | leukocyte cell derived chemotaxin 2 | |
Gene Alias | chm-II | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | O14960 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3950 | LECT2 | cirrhotic1 | Human | Liver | Cirrhotic | 4.06e-02 | -7.65e-02 | 0.0202 |
3950 | LECT2 | HCC1 | Human | Liver | HCC | 4.39e-02 | 1.03e-01 | 0.5336 |
3950 | LECT2 | S014 | Human | Liver | HCC | 7.00e-16 | 8.71e-01 | 0.2254 |
3950 | LECT2 | S016 | Human | Liver | HCC | 1.52e-09 | 8.95e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LECT2 | SNV | Missense_Mutation | rs774252570 | c.100N>T | p.Arg34Trp | p.R34W | O14960 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LECT2 | SNV | Missense_Mutation | c.131A>G | p.Tyr44Cys | p.Y44C | O14960 | protein_coding | deleterious(0.01) | probably_damaging(0.98) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
LECT2 | SNV | Missense_Mutation | c.338N>A | p.Pro113His | p.P113H | O14960 | protein_coding | tolerated(0.49) | benign(0.01) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LECT2 | SNV | Missense_Mutation | novel | c.28G>T | p.Ala10Ser | p.A10S | O14960 | protein_coding | tolerated(0.36) | benign(0.142) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LECT2 | SNV | Missense_Mutation | c.44N>A | p.Thr15Asn | p.T15N | O14960 | protein_coding | tolerated(0.49) | benign(0.188) | TCGA-44-3917-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LECT2 | SNV | Missense_Mutation | rs569920367 | c.44N>T | p.Thr15Ile | p.T15I | O14960 | protein_coding | tolerated(0.34) | benign(0.31) | TCGA-44-8120-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LECT2 | SNV | Missense_Mutation | c.74G>A | p.Cys25Tyr | p.C25Y | O14960 | protein_coding | deleterious(0.04) | probably_damaging(0.991) | TCGA-55-6972-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LECT2 | SNV | Missense_Mutation | c.328N>A | p.Tyr110Asn | p.Y110N | O14960 | protein_coding | deleterious(0.01) | benign(0.361) | TCGA-55-8203-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LECT2 | SNV | Missense_Mutation | c.374N>A | p.Pro125His | p.P125H | O14960 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-78-7220-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
LECT2 | SNV | Missense_Mutation | c.74N>A | p.Cys25Tyr | p.C25Y | O14960 | protein_coding | deleterious(0.04) | probably_damaging(0.991) | TCGA-CN-4742-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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