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Gene: LARP6 |
Gene summary for LARP6 |
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Gene information | Species | Human | Gene symbol | LARP6 | Gene ID | 55323 |
Gene name | La ribonucleoprotein 6, translational regulator | |
Gene Alias | ACHN | |
Cytomap | 15q23 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9BRS8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55323 | LARP6 | LZE4T | Human | Esophagus | ESCC | 1.52e-11 | 3.77e-01 | 0.0811 |
55323 | LARP6 | LZE5T | Human | Esophagus | ESCC | 1.12e-03 | 3.42e-01 | 0.0514 |
55323 | LARP6 | LZE22T | Human | Esophagus | ESCC | 2.27e-07 | 6.48e-01 | 0.068 |
55323 | LARP6 | LZE24T | Human | Esophagus | ESCC | 8.29e-24 | 5.56e-01 | 0.0596 |
55323 | LARP6 | P1T-E | Human | Esophagus | ESCC | 3.32e-06 | 4.48e-01 | 0.0875 |
55323 | LARP6 | P2T-E | Human | Esophagus | ESCC | 7.25e-43 | 7.32e-01 | 0.1177 |
55323 | LARP6 | P4T-E | Human | Esophagus | ESCC | 2.04e-36 | 7.94e-01 | 0.1323 |
55323 | LARP6 | P8T-E | Human | Esophagus | ESCC | 8.80e-49 | 8.74e-01 | 0.0889 |
55323 | LARP6 | P9T-E | Human | Esophagus | ESCC | 7.33e-39 | 9.83e-01 | 0.1131 |
55323 | LARP6 | P10T-E | Human | Esophagus | ESCC | 4.91e-52 | 8.08e-01 | 0.116 |
55323 | LARP6 | P11T-E | Human | Esophagus | ESCC | 1.62e-15 | 6.27e-01 | 0.1426 |
55323 | LARP6 | P12T-E | Human | Esophagus | ESCC | 2.44e-75 | 1.37e+00 | 0.1122 |
55323 | LARP6 | P15T-E | Human | Esophagus | ESCC | 7.11e-28 | 6.27e-01 | 0.1149 |
55323 | LARP6 | P16T-E | Human | Esophagus | ESCC | 1.60e-51 | 9.10e-01 | 0.1153 |
55323 | LARP6 | P17T-E | Human | Esophagus | ESCC | 4.26e-05 | 3.11e-01 | 0.1278 |
55323 | LARP6 | P19T-E | Human | Esophagus | ESCC | 3.19e-10 | 1.07e+00 | 0.1662 |
55323 | LARP6 | P20T-E | Human | Esophagus | ESCC | 4.10e-12 | 4.31e-01 | 0.1124 |
55323 | LARP6 | P21T-E | Human | Esophagus | ESCC | 1.21e-17 | 3.07e-01 | 0.1617 |
55323 | LARP6 | P22T-E | Human | Esophagus | ESCC | 2.75e-63 | 1.08e+00 | 0.1236 |
55323 | LARP6 | P23T-E | Human | Esophagus | ESCC | 2.94e-35 | 1.04e+00 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:0045727111 | Esophagus | ESCC | positive regulation of translation | 107/8552 | 136/18723 | 2.79e-15 | 1.68e-13 | 107 |
GO:0034250111 | Esophagus | ESCC | positive regulation of cellular amide metabolic process | 123/8552 | 162/18723 | 3.32e-15 | 1.93e-13 | 123 |
GO:0051099111 | Esophagus | ESCC | positive regulation of binding | 122/8552 | 173/18723 | 2.79e-11 | 9.45e-10 | 122 |
GO:19052142 | Esophagus | ESCC | regulation of RNA binding | 12/8552 | 12/18723 | 8.21e-05 | 6.01e-04 | 12 |
GO:00329631 | Esophagus | ESCC | collagen metabolic process | 62/8552 | 104/18723 | 2.90e-03 | 1.22e-02 | 62 |
GO:000641712 | Liver | Cirrhotic | regulation of translation | 194/4634 | 468/18723 | 7.28e-16 | 8.79e-14 | 194 |
GO:00457277 | Liver | Cirrhotic | positive regulation of translation | 71/4634 | 136/18723 | 4.99e-12 | 3.52e-10 | 71 |
GO:005109812 | Liver | Cirrhotic | regulation of binding | 148/4634 | 363/18723 | 9.14e-12 | 5.97e-10 | 148 |
GO:003425012 | Liver | Cirrhotic | positive regulation of cellular amide metabolic process | 78/4634 | 162/18723 | 8.62e-11 | 4.66e-09 | 78 |
GO:005109912 | Liver | Cirrhotic | positive regulation of binding | 74/4634 | 173/18723 | 1.44e-07 | 3.87e-06 | 74 |
GO:000641722 | Liver | HCC | regulation of translation | 287/7958 | 468/18723 | 8.79e-17 | 8.08e-15 | 287 |
GO:005109822 | Liver | HCC | regulation of binding | 225/7958 | 363/18723 | 3.78e-14 | 2.37e-12 | 225 |
GO:004572712 | Liver | HCC | positive regulation of translation | 97/7958 | 136/18723 | 8.51e-12 | 3.55e-10 | 97 |
GO:003425022 | Liver | HCC | positive regulation of cellular amide metabolic process | 110/7958 | 162/18723 | 5.14e-11 | 1.92e-09 | 110 |
GO:005109922 | Liver | HCC | positive regulation of binding | 108/7958 | 173/18723 | 9.22e-08 | 1.83e-06 | 108 |
GO:1905214 | Liver | HCC | regulation of RNA binding | 10/7958 | 12/18723 | 4.79e-03 | 2.02e-02 | 10 |
GO:000641720 | Oral cavity | OSCC | regulation of translation | 274/7305 | 468/18723 | 4.39e-18 | 4.63e-16 | 274 |
GO:004572719 | Oral cavity | OSCC | positive regulation of translation | 101/7305 | 136/18723 | 5.85e-17 | 4.94e-15 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LARP6 | SNV | Missense_Mutation | rs372104696 | c.1307N>A | p.Arg436His | p.R436H | Q9BRS8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
LARP6 | SNV | Missense_Mutation | rs532492757 | c.459N>T | p.Lys153Asn | p.K153N | Q9BRS8 | protein_coding | tolerated(0.09) | possibly_damaging(0.723) | TCGA-AA-A02E-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
LARP6 | SNV | Missense_Mutation | rs561519879 | c.1174N>A | p.Val392Ile | p.V392I | Q9BRS8 | protein_coding | tolerated(0.29) | benign(0) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
LARP6 | SNV | Missense_Mutation | novel | c.1417N>G | p.Arg473Gly | p.R473G | Q9BRS8 | protein_coding | tolerated(0.09) | possibly_damaging(0.723) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LARP6 | SNV | Missense_Mutation | c.128C>T | p.Ala43Val | p.A43V | Q9BRS8 | protein_coding | tolerated_low_confidence(0.24) | benign(0.01) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
LARP6 | SNV | Missense_Mutation | rs201700915 | c.1396G>A | p.Val466Ile | p.V466I | Q9BRS8 | protein_coding | tolerated(0.3) | benign(0.403) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
LARP6 | SNV | Missense_Mutation | rs770915412 | c.935N>T | p.Ala312Val | p.A312V | Q9BRS8 | protein_coding | tolerated(0.29) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LARP6 | SNV | Missense_Mutation | rs772667024 | c.664N>A | p.Gly222Arg | p.G222R | Q9BRS8 | protein_coding | tolerated(0.08) | possibly_damaging(0.572) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LARP6 | SNV | Missense_Mutation | rs772932234 | c.1310N>A | p.Arg437His | p.R437H | Q9BRS8 | protein_coding | deleterious(0.01) | possibly_damaging(0.869) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LARP6 | SNV | Missense_Mutation | rs561519879 | c.1174G>A | p.Val392Ile | p.V392I | Q9BRS8 | protein_coding | tolerated(0.29) | benign(0) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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