|
Gene: KRT75 |
Gene summary for KRT75 |
Gene summary. |
Gene information | Species | Human | Gene symbol | KRT75 | Gene ID | 9119 |
Gene name | keratin 75 | |
Gene Alias | CK-75 | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0002244 | UniProtAcc | O95678 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9119 | KRT75 | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.49e-04 | 1.51e-01 | -0.0811 |
9119 | KRT75 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.07e-04 | 1.55e-01 | -0.1464 |
9119 | KRT75 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.47e-06 | 1.69e-01 | -0.059 |
9119 | KRT75 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.48e-10 | 3.00e-01 | 0.0588 |
9119 | KRT75 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.04e-05 | 1.12e-01 | 0.294 |
9119 | KRT75 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.82e-03 | 1.18e-01 | 0.3859 |
9119 | KRT75 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.62e-04 | 1.21e-01 | 0.3005 |
9119 | KRT75 | P10T-E | Human | Esophagus | ESCC | 5.00e-17 | 5.31e-01 | 0.116 |
9119 | KRT75 | P11T-E | Human | Esophagus | ESCC | 3.25e-05 | 3.22e-01 | 0.1426 |
9119 | KRT75 | P19T-E | Human | Esophagus | ESCC | 7.48e-03 | 4.05e-01 | 0.1662 |
9119 | KRT75 | P21T-E | Human | Esophagus | ESCC | 4.17e-05 | 3.77e-01 | 0.1617 |
9119 | KRT75 | P22T-E | Human | Esophagus | ESCC | 4.44e-08 | 2.80e-01 | 0.1236 |
9119 | KRT75 | P24T-E | Human | Esophagus | ESCC | 1.66e-02 | 2.04e-01 | 0.1287 |
9119 | KRT75 | P31T-E | Human | Esophagus | ESCC | 6.89e-44 | 1.69e+00 | 0.1251 |
9119 | KRT75 | P37T-E | Human | Esophagus | ESCC | 6.65e-04 | 1.69e-01 | 0.1371 |
9119 | KRT75 | P42T-E | Human | Esophagus | ESCC | 3.05e-02 | 2.42e-01 | 0.1175 |
9119 | KRT75 | P52T-E | Human | Esophagus | ESCC | 7.98e-13 | 6.18e-01 | 0.1555 |
9119 | KRT75 | P61T-E | Human | Esophagus | ESCC | 2.42e-03 | 2.39e-01 | 0.099 |
9119 | KRT75 | P76T-E | Human | Esophagus | ESCC | 8.84e-05 | 2.77e-01 | 0.1207 |
9119 | KRT75 | P80T-E | Human | Esophagus | ESCC | 8.76e-16 | 1.28e+00 | 0.155 |
Page: 1 2 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002244 | Colorectum | MSS | hematopoietic progenitor cell differentiation | 32/3467 | 114/18723 | 8.07e-03 | 4.91e-02 | 32 |
GO:00022446 | Esophagus | ESCC | hematopoietic progenitor cell differentiation | 66/8552 | 114/18723 | 5.74e-03 | 2.13e-02 | 66 |
GO:00022445 | Oral cavity | OSCC | hematopoietic progenitor cell differentiation | 57/7305 | 114/18723 | 1.09e-02 | 3.71e-02 | 57 |
GO:000224413 | Skin | cSCC | hematopoietic progenitor cell differentiation | 42/4864 | 114/18723 | 6.74e-03 | 3.27e-02 | 42 |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KRT75 | SNV | Missense_Mutation | rs756416874 | c.737N>A | p.Arg246His | p.R246H | O95678 | protein_coding | tolerated(0.06) | possibly_damaging(0.597) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
KRT75 | SNV | Missense_Mutation | c.641N>C | p.Ile214Thr | p.I214T | O95678 | protein_coding | deleterious(0.02) | benign(0.098) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KRT75 | SNV | Missense_Mutation | c.1483G>T | p.Gly495Cys | p.G495C | O95678 | protein_coding | tolerated(0.06) | possibly_damaging(0.907) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KRT75 | SNV | Missense_Mutation | rs748576441 | c.343N>A | p.Val115Met | p.V115M | O95678 | protein_coding | tolerated(0.08) | benign(0.158) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KRT75 | SNV | Missense_Mutation | c.507N>A | p.Phe169Leu | p.F169L | O95678 | protein_coding | deleterious(0) | possibly_damaging(0.768) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
KRT75 | SNV | Missense_Mutation | rs760354917 | c.767N>C | p.Leu256Pro | p.L256P | O95678 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
KRT75 | SNV | Missense_Mutation | rs779742513 | c.736N>T | p.Arg246Cys | p.R246C | O95678 | protein_coding | deleterious(0.02) | possibly_damaging(0.597) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KRT75 | SNV | Missense_Mutation | c.1568N>T | p.Ala523Val | p.A523V | O95678 | protein_coding | tolerated(0.11) | benign(0.012) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KRT75 | insertion | Frame_Shift_Ins | novel | c.1172_1173insT | p.Leu391PhefsTer7 | p.L391Ffs*7 | O95678 | protein_coding | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | ||
KRT75 | SNV | Missense_Mutation | novel | c.554N>G | p.Gln185Arg | p.Q185R | O95678 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |