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Gene: KLHL29 |
Gene summary for KLHL29 |
Gene summary. |
Gene information | Species | Human | Gene symbol | KLHL29 | Gene ID | 114818 |
Gene name | kelch like family member 29 | |
Gene Alias | KBTBD9 | |
Cytomap | 2p24.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q96CT2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114818 | KLHL29 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.10e-03 | 1.73e-02 | -0.1954 |
114818 | KLHL29 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.84e-05 | 2.81e-01 | -0.1464 |
114818 | KLHL29 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.54e-10 | 3.76e-01 | 0.096 |
114818 | KLHL29 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.06e-03 | 2.49e-01 | 0.0338 |
114818 | KLHL29 | HTA11_6818_2000001011 | Human | Colorectum | AD | 4.04e-02 | 4.87e-01 | 0.0112 |
114818 | KLHL29 | HTA11_6818_2000001021 | Human | Colorectum | AD | 5.13e-06 | 5.62e-01 | 0.0588 |
114818 | KLHL29 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.18e-03 | 2.41e-01 | 0.294 |
114818 | KLHL29 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.17e-22 | 6.81e-01 | 0.3859 |
114818 | KLHL29 | CRC-3-11773 | Human | Colorectum | CRC | 7.90e-11 | 4.89e-01 | 0.2564 |
114818 | KLHL29 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 2.30e-08 | 5.45e-01 | -0.2116 |
114818 | KLHL29 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.72e-10 | 6.94e-01 | -0.2119 |
114818 | KLHL29 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 7.30e-09 | 3.97e-01 | -0.0132 |
114818 | KLHL29 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 4.78e-13 | 4.67e-01 | -0.013 |
114818 | KLHL29 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 5.57e-05 | 3.41e-01 | -0.0121 |
114818 | KLHL29 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 2.95e-03 | 5.12e-01 | -0.0961 |
114818 | KLHL29 | HTA12-15-2 | Human | Pancreas | PDAC | 4.41e-04 | 2.83e-01 | 0.2315 |
114818 | KLHL29 | HTA12-23-1 | Human | Pancreas | PDAC | 2.93e-09 | 8.35e-01 | 0.3405 |
114818 | KLHL29 | HTA12-25-1 | Human | Pancreas | PDAC | 2.41e-10 | 7.39e-01 | 0.313 |
114818 | KLHL29 | HTA12-26-1 | Human | Pancreas | PDAC | 3.27e-24 | 1.01e+00 | 0.3728 |
114818 | KLHL29 | HTA12-29-1 | Human | Pancreas | PDAC | 3.68e-32 | 6.95e-01 | 0.3722 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLHL29 | SNV | Missense_Mutation | rs776390206 | c.1133N>T | p.Ser378Leu | p.S378L | Q96CT2 | protein_coding | deleterious(0.04) | benign(0.102) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KLHL29 | SNV | Missense_Mutation | c.1571N>A | p.Arg524His | p.R524H | Q96CT2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KLHL29 | SNV | Missense_Mutation | novel | c.1440N>A | p.Phe480Leu | p.F480L | Q96CT2 | protein_coding | tolerated(1) | benign(0.001) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
KLHL29 | SNV | Missense_Mutation | c.1571G>A | p.Arg524His | p.R524H | Q96CT2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CM-5348-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
KLHL29 | SNV | Missense_Mutation | c.1550N>G | p.Ala517Gly | p.A517G | Q96CT2 | protein_coding | tolerated(0.2) | benign(0.005) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KLHL29 | SNV | Missense_Mutation | c.340N>T | p.Arg114Trp | p.R114W | Q96CT2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KLHL29 | SNV | Missense_Mutation | c.2141C>G | p.Ala714Gly | p.A714G | Q96CT2 | protein_coding | deleterious(0.01) | benign(0.127) | TCGA-NH-A50V-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR | |
KLHL29 | SNV | Missense_Mutation | rs751666224 | c.763N>A | p.Gly255Ser | p.G255S | Q96CT2 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.975) | TCGA-NH-A8F7-06 | Colorectum | NA | NA | NA | NA | NA | NA | NA |
KLHL29 | SNV | Missense_Mutation | novel | c.1278N>A | p.Phe426Leu | p.F426L | Q96CT2 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-T9-A92H-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KLHL29 | SNV | Missense_Mutation | novel | c.1279N>A | p.Leu427Ile | p.L427I | Q96CT2 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-T9-A92H-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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