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Gene: KLHL28 |
Gene summary for KLHL28 |
Gene summary. |
Gene information | Species | Human | Gene symbol | KLHL28 | Gene ID | 54813 |
Gene name | kelch like family member 28 | |
Gene Alias | BTBD5 | |
Cytomap | 14q21.2 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A8K1E0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54813 | KLHL28 | LZE4T | Human | Esophagus | ESCC | 1.14e-15 | 4.99e-01 | 0.0811 |
54813 | KLHL28 | LZE5T | Human | Esophagus | ESCC | 1.59e-02 | 2.88e-01 | 0.0514 |
54813 | KLHL28 | LZE7T | Human | Esophagus | ESCC | 1.99e-02 | 1.11e-01 | 0.0667 |
54813 | KLHL28 | LZE20T | Human | Esophagus | ESCC | 4.46e-03 | 1.06e-01 | 0.0662 |
54813 | KLHL28 | LZE24T | Human | Esophagus | ESCC | 5.72e-11 | 3.85e-01 | 0.0596 |
54813 | KLHL28 | P2T-E | Human | Esophagus | ESCC | 1.25e-17 | 2.27e-01 | 0.1177 |
54813 | KLHL28 | P4T-E | Human | Esophagus | ESCC | 1.10e-12 | 3.90e-01 | 0.1323 |
54813 | KLHL28 | P5T-E | Human | Esophagus | ESCC | 6.34e-14 | 2.37e-01 | 0.1327 |
54813 | KLHL28 | P8T-E | Human | Esophagus | ESCC | 1.04e-13 | 2.40e-01 | 0.0889 |
54813 | KLHL28 | P9T-E | Human | Esophagus | ESCC | 2.50e-10 | 1.28e-01 | 0.1131 |
54813 | KLHL28 | P10T-E | Human | Esophagus | ESCC | 2.30e-24 | 4.90e-01 | 0.116 |
54813 | KLHL28 | P11T-E | Human | Esophagus | ESCC | 3.65e-10 | 3.93e-01 | 0.1426 |
54813 | KLHL28 | P12T-E | Human | Esophagus | ESCC | 3.89e-32 | 6.12e-01 | 0.1122 |
54813 | KLHL28 | P15T-E | Human | Esophagus | ESCC | 2.25e-34 | 6.93e-01 | 0.1149 |
54813 | KLHL28 | P16T-E | Human | Esophagus | ESCC | 1.72e-20 | 3.84e-01 | 0.1153 |
54813 | KLHL28 | P17T-E | Human | Esophagus | ESCC | 1.55e-03 | 2.37e-01 | 0.1278 |
54813 | KLHL28 | P20T-E | Human | Esophagus | ESCC | 5.14e-10 | 2.77e-01 | 0.1124 |
54813 | KLHL28 | P21T-E | Human | Esophagus | ESCC | 1.58e-09 | 2.13e-01 | 0.1617 |
54813 | KLHL28 | P22T-E | Human | Esophagus | ESCC | 2.93e-12 | 1.50e-01 | 0.1236 |
54813 | KLHL28 | P23T-E | Human | Esophagus | ESCC | 5.05e-18 | 3.84e-01 | 0.108 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLHL28 | SNV | Missense_Mutation | c.1145N>A | p.Ser382Tyr | p.S382Y | protein_coding | deleterious(0.04) | possibly_damaging(0.601) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | ||
KLHL28 | SNV | Missense_Mutation | rs753214894 | c.716N>A | p.Arg239Gln | p.R239Q | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KLHL28 | SNV | Missense_Mutation | c.128G>A | p.Arg43His | p.R43H | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | ||
KLHL28 | SNV | Missense_Mutation | novel | c.424C>A | p.Leu142Ile | p.L142I | protein_coding | deleterious(0.01) | probably_damaging(0.962) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KLHL28 | SNV | Missense_Mutation | novel | c.1030G>T | p.Asp344Tyr | p.D344Y | protein_coding | tolerated(0.06) | probably_damaging(0.99) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
KLHL28 | SNV | Missense_Mutation | rs779407331 | c.139N>A | p.Glu47Lys | p.E47K | protein_coding | tolerated(0.28) | probably_damaging(0.959) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KLHL28 | SNV | Missense_Mutation | novel | c.1622A>G | p.Tyr541Cys | p.Y541C | protein_coding | tolerated(0.18) | probably_damaging(0.936) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
KLHL28 | SNV | Missense_Mutation | novel | c.1643N>G | p.His548Arg | p.H548R | protein_coding | tolerated(0.56) | probably_damaging(0.982) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
KLHL28 | SNV | Missense_Mutation | novel | c.197N>C | p.Val66Ala | p.V66A | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KLHL28 | SNV | Missense_Mutation | novel | c.1373C>T | p.Ala458Val | p.A458V | protein_coding | deleterious(0.01) | possibly_damaging(0.511) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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