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Gene: KLHL2 |
Gene summary for KLHL2 |
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Gene information | Species | Human | Gene symbol | KLHL2 | Gene ID | 11275 |
Gene name | kelch like family member 2 | |
Gene Alias | ABP-KELCH | |
Cytomap | 4q32.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | O95198 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11275 | KLHL2 | CCI_1 | Human | Cervix | CC | 1.29e-02 | 5.89e-01 | 0.528 |
11275 | KLHL2 | CCI_2 | Human | Cervix | CC | 4.68e-04 | 9.53e-01 | 0.5249 |
11275 | KLHL2 | CCI_3 | Human | Cervix | CC | 1.68e-04 | 5.80e-01 | 0.516 |
11275 | KLHL2 | HTA12-15-2 | Human | Pancreas | PDAC | 3.81e-02 | 3.41e-01 | 0.2315 |
11275 | KLHL2 | HTA12-25-1 | Human | Pancreas | PDAC | 1.12e-07 | 7.86e-01 | 0.313 |
11275 | KLHL2 | HTA12-26-1 | Human | Pancreas | PDAC | 2.80e-17 | 8.93e-01 | 0.3728 |
11275 | KLHL2 | HTA12-29-1 | Human | Pancreas | PDAC | 5.12e-18 | 4.96e-01 | 0.3722 |
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Tissue | Expression Dynamics | Abbreviation |
Cervix | ![]() | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
N_HPV: HPV-infected normal cervix |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:00002097 | Cervix | CC | protein polyubiquitination | 58/2311 | 236/18723 | 1.57e-07 | 7.41e-06 | 58 |
GO:00068927 | Cervix | CC | post-Golgi vesicle-mediated transport | 28/2311 | 104/18723 | 4.31e-05 | 6.61e-04 | 28 |
GO:00481938 | Cervix | CC | Golgi vesicle transport | 58/2311 | 296/18723 | 2.24e-04 | 2.54e-03 | 58 |
GO:19023059 | Cervix | CC | regulation of sodium ion transmembrane transport | 19/2311 | 68/18723 | 4.21e-04 | 4.25e-03 | 19 |
GO:00451043 | Cervix | CC | intermediate filament cytoskeleton organization | 15/2311 | 51/18723 | 9.25e-04 | 7.84e-03 | 15 |
GO:00451033 | Cervix | CC | intermediate filament-based process | 15/2311 | 52/18723 | 1.15e-03 | 9.39e-03 | 15 |
GO:00020288 | Cervix | CC | regulation of sodium ion transport | 21/2311 | 90/18723 | 2.71e-03 | 1.85e-02 | 21 |
GO:20006498 | Cervix | CC | regulation of sodium ion transmembrane transporter activity | 15/2311 | 58/18723 | 3.75e-03 | 2.38e-02 | 15 |
GO:00164827 | Cervix | CC | cytosolic transport | 33/2311 | 168/18723 | 4.43e-03 | 2.70e-02 | 33 |
GO:00518656 | Cervix | CC | protein autoubiquitination | 17/2311 | 73/18723 | 6.71e-03 | 3.70e-02 | 17 |
GO:0002028 | Colorectum | AD | regulation of sodium ion transport | 36/3918 | 90/18723 | 2.89e-05 | 5.37e-04 | 36 |
GO:1902305 | Colorectum | AD | regulation of sodium ion transmembrane transport | 27/3918 | 68/18723 | 3.19e-04 | 3.80e-03 | 27 |
GO:0051865 | Colorectum | AD | protein autoubiquitination | 28/3918 | 73/18723 | 4.87e-04 | 5.30e-03 | 28 |
GO:2000649 | Colorectum | AD | regulation of sodium ion transmembrane transporter activity | 23/3918 | 58/18723 | 8.82e-04 | 8.53e-03 | 23 |
GO:00020282 | Colorectum | MSS | regulation of sodium ion transport | 32/3467 | 90/18723 | 9.56e-05 | 1.50e-03 | 32 |
GO:19023052 | Colorectum | MSS | regulation of sodium ion transmembrane transport | 26/3467 | 68/18723 | 1.08e-04 | 1.68e-03 | 26 |
GO:20006492 | Colorectum | MSS | regulation of sodium ion transmembrane transporter activity | 22/3467 | 58/18723 | 4.06e-04 | 4.99e-03 | 22 |
GO:00518651 | Colorectum | MSS | protein autoubiquitination | 25/3467 | 73/18723 | 1.00e-03 | 1.00e-02 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLHL2 | SNV | Missense_Mutation | novel | c.1232N>T | p.Gly411Val | p.G411V | O95198 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KLHL2 | SNV | Missense_Mutation | c.1259N>T | p.Ser420Phe | p.S420F | O95198 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
KLHL2 | SNV | Missense_Mutation | novel | c.550N>A | p.Tyr184Asn | p.Y184N | O95198 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KLHL2 | SNV | Missense_Mutation | novel | c.19N>T | p.Arg7Trp | p.R7W | O95198 | protein_coding | deleterious_low_confidence(0.03) | benign(0.007) | TCGA-D5-6924-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KLHL2 | SNV | Missense_Mutation | c.1223N>A | p.Ala408Asp | p.A408D | O95198 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-QG-A5Z1-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | ||
KLHL2 | SNV | Missense_Mutation | c.154N>A | p.Glu52Lys | p.E52K | O95198 | protein_coding | tolerated(0.19) | possibly_damaging(0.506) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KLHL2 | insertion | In_Frame_Ins | novel | c.548_549insACACAT | p.Thr183_Tyr184insHisIle | p.T183_Y184insHI | O95198 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KLHL2 | SNV | Missense_Mutation | novel | c.991N>A | p.Asp331Asn | p.D331N | O95198 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KLHL2 | SNV | Missense_Mutation | c.1736N>T | p.Ser579Leu | p.S579L | O95198 | protein_coding | deleterious(0.03) | possibly_damaging(0.623) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KLHL2 | SNV | Missense_Mutation | novel | c.168N>C | p.Gln56His | p.Q56H | O95198 | protein_coding | tolerated(0.1) | benign(0.178) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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