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Gene: KLHL11 |
Gene summary for KLHL11 |
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Gene information | Species | Human | Gene symbol | KLHL11 | Gene ID | 55175 |
Gene name | kelch like family member 11 | |
Gene Alias | KLHL11 | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R1T8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55175 | KLHL11 | LZE4T | Human | Esophagus | ESCC | 7.96e-15 | 3.63e-01 | 0.0811 |
55175 | KLHL11 | LZE7T | Human | Esophagus | ESCC | 3.01e-10 | 3.83e-01 | 0.0667 |
55175 | KLHL11 | LZE21D1 | Human | Esophagus | HGIN | 4.41e-04 | 2.97e-01 | 0.0632 |
55175 | KLHL11 | LZE22T | Human | Esophagus | ESCC | 1.57e-02 | 3.63e-01 | 0.068 |
55175 | KLHL11 | LZE24T | Human | Esophagus | ESCC | 7.41e-13 | 2.98e-01 | 0.0596 |
55175 | KLHL11 | LZE22D3 | Human | Esophagus | HGIN | 1.73e-02 | 3.63e-01 | 0.0653 |
55175 | KLHL11 | LZE21T | Human | Esophagus | ESCC | 6.52e-03 | 2.06e-01 | 0.0655 |
55175 | KLHL11 | P1T-E | Human | Esophagus | ESCC | 3.58e-07 | 3.13e-01 | 0.0875 |
55175 | KLHL11 | P2T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.12e-01 | 0.1177 |
55175 | KLHL11 | P4T-E | Human | Esophagus | ESCC | 1.05e-03 | 1.29e-01 | 0.1323 |
55175 | KLHL11 | P5T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.72e-01 | 0.1327 |
55175 | KLHL11 | P8T-E | Human | Esophagus | ESCC | 1.66e-02 | 8.31e-02 | 0.0889 |
55175 | KLHL11 | P11T-E | Human | Esophagus | ESCC | 1.13e-06 | 2.94e-01 | 0.1426 |
55175 | KLHL11 | P12T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.65e-01 | 0.1122 |
55175 | KLHL11 | P15T-E | Human | Esophagus | ESCC | 4.46e-14 | 2.79e-01 | 0.1149 |
55175 | KLHL11 | P16T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.43e-01 | 0.1153 |
55175 | KLHL11 | P20T-E | Human | Esophagus | ESCC | 1.16e-15 | 3.36e-01 | 0.1124 |
55175 | KLHL11 | P21T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.29e-01 | 0.1617 |
55175 | KLHL11 | P22T-E | Human | Esophagus | ESCC | 3.52e-19 | 3.39e-01 | 0.1236 |
55175 | KLHL11 | P23T-E | Human | Esophagus | ESCC | 2.37e-12 | 2.90e-01 | 0.108 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLHL11 | SNV | Missense_Mutation | c.613N>G | p.Cys205Gly | p.C205G | Q9NVR0 | protein_coding | deleterious(0.01) | probably_damaging(0.952) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KLHL11 | SNV | Missense_Mutation | novel | c.266N>A | p.Arg89His | p.R89H | Q9NVR0 | protein_coding | tolerated(0.09) | possibly_damaging(0.466) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KLHL11 | SNV | Missense_Mutation | novel | c.719N>G | p.Glu240Gly | p.E240G | Q9NVR0 | protein_coding | deleterious(0.01) | possibly_damaging(0.792) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD |
KLHL11 | SNV | Missense_Mutation | c.1307T>C | p.Val436Ala | p.V436A | Q9NVR0 | protein_coding | deleterious(0.01) | probably_damaging(0.945) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KLHL11 | SNV | Missense_Mutation | c.1018A>T | p.Thr340Ser | p.T340S | Q9NVR0 | protein_coding | tolerated(0.5) | benign(0.003) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KLHL11 | SNV | Missense_Mutation | c.1642N>G | p.Phe548Val | p.F548V | Q9NVR0 | protein_coding | tolerated(0.5) | benign(0) | TCGA-CM-4751-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
KLHL11 | SNV | Missense_Mutation | c.1016N>A | p.Gly339Asp | p.G339D | Q9NVR0 | protein_coding | tolerated(0.17) | benign(0.121) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KLHL11 | SNV | Missense_Mutation | novel | c.723N>G | p.Phe241Leu | p.F241L | Q9NVR0 | protein_coding | tolerated(0.43) | possibly_damaging(0.684) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
KLHL11 | deletion | Frame_Shift_Del | novel | c.1586_1587delNN | p.Thr529ArgfsTer15 | p.T529Rfs*15 | Q9NVR0 | protein_coding | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
KLHL11 | deletion | Frame_Shift_Del | c.197delC | p.Pro66GlnfsTer92 | p.P66Qfs*92 | Q9NVR0 | protein_coding | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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