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Gene: KLF5 |
Gene summary for KLF5 |
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Gene information | Species | Human | Gene symbol | KLF5 | Gene ID | 688 |
Gene name | Kruppel like factor 5 | |
Gene Alias | BTEB2 | |
Cytomap | 13q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q13887 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
688 | KLF5 | CA_HPV_1 | Human | Cervix | CC | 1.72e-10 | -3.73e-01 | 0.0264 |
688 | KLF5 | CA_HPV_3 | Human | Cervix | CC | 5.22e-04 | 1.83e-01 | 0.0414 |
688 | KLF5 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 5.93e-04 | -3.29e-01 | 0.0116 |
688 | KLF5 | CCI_1 | Human | Cervix | CC | 1.75e-09 | 1.35e+00 | 0.528 |
688 | KLF5 | CCI_2 | Human | Cervix | CC | 3.11e-02 | 6.41e-01 | 0.5249 |
688 | KLF5 | CCI_3 | Human | Cervix | CC | 8.15e-03 | 6.79e-01 | 0.516 |
688 | KLF5 | Tumor | Human | Cervix | CC | 1.83e-30 | 7.09e-01 | 0.1241 |
688 | KLF5 | sample3 | Human | Cervix | CC | 5.93e-58 | 8.55e-01 | 0.1387 |
688 | KLF5 | H2 | Human | Cervix | HSIL_HPV | 5.86e-11 | 4.51e-01 | 0.0632 |
688 | KLF5 | L1 | Human | Cervix | CC | 1.49e-03 | 3.89e-01 | 0.0802 |
688 | KLF5 | T1 | Human | Cervix | CC | 3.46e-07 | 4.21e-01 | 0.0918 |
688 | KLF5 | T2 | Human | Cervix | CC | 1.77e-04 | 5.97e-01 | 0.0709 |
688 | KLF5 | T3 | Human | Cervix | CC | 1.18e-50 | 8.52e-01 | 0.1389 |
688 | KLF5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.10e-11 | -4.06e-01 | 0.0155 |
688 | KLF5 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.67e-40 | 1.35e+00 | -0.1954 |
688 | KLF5 | HTA11_411_2000001011 | Human | Colorectum | SER | 6.74e-12 | 9.87e-01 | -0.2602 |
688 | KLF5 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.96e-05 | 4.61e-01 | -0.1464 |
688 | KLF5 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.38e-03 | 3.89e-01 | -0.1001 |
688 | KLF5 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.88e-05 | 5.82e-01 | -0.0842 |
688 | KLF5 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.25e-02 | -5.32e-01 | 0.0451 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00454445 | Cervix | CC | fat cell differentiation | 53/2311 | 229/18723 | 3.72e-06 | 9.75e-05 | 53 |
GO:00616148 | Cervix | CC | pri-miRNA transcription by RNA polymerase II | 20/2311 | 55/18723 | 4.22e-06 | 1.09e-04 | 20 |
GO:19028938 | Cervix | CC | regulation of pri-miRNA transcription by RNA polymerase II | 19/2311 | 54/18723 | 1.27e-05 | 2.60e-04 | 19 |
GO:00310996 | Cervix | CC | regeneration | 46/2311 | 198/18723 | 1.43e-05 | 2.84e-04 | 46 |
GO:19016538 | Cervix | CC | cellular response to peptide | 72/2311 | 359/18723 | 1.89e-05 | 3.48e-04 | 72 |
GO:19028955 | Cervix | CC | positive regulation of pri-miRNA transcription by RNA polymerase II | 15/2311 | 42/18723 | 8.42e-05 | 1.13e-03 | 15 |
GO:00605375 | Cervix | CC | muscle tissue development | 76/2311 | 403/18723 | 9.76e-05 | 1.27e-03 | 76 |
GO:00147064 | Cervix | CC | striated muscle tissue development | 72/2311 | 384/18723 | 1.76e-04 | 2.07e-03 | 72 |
GO:000206410 | Cervix | CC | epithelial cell development | 45/2311 | 220/18723 | 4.14e-04 | 4.21e-03 | 45 |
GO:0045598 | Cervix | CC | regulation of fat cell differentiation | 31/2311 | 139/18723 | 7.06e-04 | 6.41e-03 | 31 |
GO:00456004 | Cervix | CC | positive regulation of fat cell differentiation | 18/2311 | 66/18723 | 8.09e-04 | 7.07e-03 | 18 |
GO:00426924 | Cervix | CC | muscle cell differentiation | 69/2311 | 384/18723 | 8.12e-04 | 7.09e-03 | 69 |
GO:0042246 | Cervix | CC | tissue regeneration | 19/2311 | 72/18723 | 9.11e-04 | 7.81e-03 | 19 |
GO:01200328 | Cervix | CC | regulation of plasma membrane bounded cell projection assembly | 38/2311 | 186/18723 | 1.14e-03 | 9.35e-03 | 38 |
GO:00434032 | Cervix | CC | skeletal muscle tissue regeneration | 12/2311 | 37/18723 | 1.15e-03 | 9.39e-03 | 12 |
GO:00604917 | Cervix | CC | regulation of cell projection assembly | 38/2311 | 188/18723 | 1.40e-03 | 1.10e-02 | 38 |
GO:00300337 | Cervix | CC | microvillus assembly | 7/2311 | 16/18723 | 1.79e-03 | 1.34e-02 | 7 |
GO:19908234 | Cervix | CC | response to leukemia inhibitory factor | 22/2311 | 95/18723 | 2.40e-03 | 1.70e-02 | 22 |
GO:00075173 | Cervix | CC | muscle organ development | 58/2311 | 327/18723 | 2.73e-03 | 1.85e-02 | 58 |
GO:19908304 | Cervix | CC | cellular response to leukemia inhibitory factor | 21/2311 | 94/18723 | 4.68e-03 | 2.82e-02 | 21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05207 | Colorectum | CRC | Chemical carcinogenesis - receptor activation | 42/1091 | 212/8465 | 2.62e-03 | 1.75e-02 | 1.19e-02 | 42 |
hsa052071 | Colorectum | CRC | Chemical carcinogenesis - receptor activation | 42/1091 | 212/8465 | 2.62e-03 | 1.75e-02 | 1.19e-02 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLF5 | SNV | Missense_Mutation | c.919N>G | p.Ser307Ala | p.S307A | Q13887 | protein_coding | deleterious(0.01) | probably_damaging(0.967) | TCGA-A6-5666-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KLF5 | SNV | Missense_Mutation | rs750391044 | c.421N>T | p.Pro141Ser | p.P141S | Q13887 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KLF5 | SNV | Missense_Mutation | c.932G>T | p.Ser311Ile | p.S311I | Q13887 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AZ-6608-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
KLF5 | SNV | Missense_Mutation | c.1024A>T | p.Asn342Tyr | p.N342Y | Q13887 | protein_coding | tolerated(0.05) | possibly_damaging(0.564) | TCGA-CM-6161-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KLF5 | SNV | Missense_Mutation | c.293N>G | p.Pro98Arg | p.P98R | Q13887 | protein_coding | deleterious(0.05) | benign(0.044) | TCGA-CM-6163-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KLF5 | SNV | Missense_Mutation | c.322G>A | p.Glu108Lys | p.E108K | Q13887 | protein_coding | tolerated(0.11) | benign(0.107) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KLF5 | SNV | Missense_Mutation | rs867921927 | c.911N>T | p.Pro304Leu | p.P304L | Q13887 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-F5-6864-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
KLF5 | deletion | Frame_Shift_Del | novel | c.690delN | p.Gln230HisfsTer3 | p.Q230Hfs*3 | Q13887 | protein_coding | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KLF5 | SNV | Missense_Mutation | c.725N>A | p.Ser242Tyr | p.S242Y | Q13887 | protein_coding | tolerated(0.16) | benign(0.365) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KLF5 | SNV | Missense_Mutation | novel | c.827A>G | p.Lys276Arg | p.K276R | Q13887 | protein_coding | tolerated(0.14) | possibly_damaging(0.549) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
688 | KLF5 | TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | OUABAIN | OUABAIN | ||
688 | KLF5 | TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | CID 926663 | CHEMBL265686 | ||
688 | KLF5 | TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | CID 838877 | CHEMBL405317 | ||
688 | KLF5 | TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | TCMDC-125567 | CHEMBL530049 |
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