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Gene: KLF16 |
Gene summary for KLF16 |
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Gene information | Species | Human | Gene symbol | KLF16 | Gene ID | 83855 |
Gene name | Kruppel like factor 16 | |
Gene Alias | BTEB4 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9BXK1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83855 | KLF16 | HCC1_Meng | Human | Liver | HCC | 1.34e-08 | 1.26e-02 | 0.0246 |
83855 | KLF16 | HCC2_Meng | Human | Liver | HCC | 1.30e-12 | 1.19e-01 | 0.0107 |
83855 | KLF16 | HCC2 | Human | Liver | HCC | 1.72e-06 | 7.90e-01 | 0.5341 |
83855 | KLF16 | S014 | Human | Liver | HCC | 1.60e-04 | 2.19e-01 | 0.2254 |
83855 | KLF16 | S015 | Human | Liver | HCC | 1.86e-09 | 3.60e-01 | 0.2375 |
83855 | KLF16 | S016 | Human | Liver | HCC | 2.04e-12 | 3.06e-01 | 0.2243 |
83855 | KLF16 | S027 | Human | Liver | HCC | 2.49e-06 | 6.04e-01 | 0.2446 |
83855 | KLF16 | S028 | Human | Liver | HCC | 3.39e-18 | 4.88e-01 | 0.2503 |
83855 | KLF16 | S029 | Human | Liver | HCC | 3.22e-16 | 5.06e-01 | 0.2581 |
83855 | KLF16 | C04 | Human | Oral cavity | OSCC | 1.35e-08 | 5.92e-01 | 0.2633 |
83855 | KLF16 | C21 | Human | Oral cavity | OSCC | 1.57e-05 | 1.56e-01 | 0.2678 |
83855 | KLF16 | C30 | Human | Oral cavity | OSCC | 1.19e-21 | 8.16e-01 | 0.3055 |
83855 | KLF16 | C38 | Human | Oral cavity | OSCC | 1.75e-03 | 4.52e-01 | 0.172 |
83855 | KLF16 | C46 | Human | Oral cavity | OSCC | 4.33e-02 | 8.38e-02 | 0.1673 |
83855 | KLF16 | C51 | Human | Oral cavity | OSCC | 4.18e-06 | 4.55e-01 | 0.2674 |
83855 | KLF16 | C57 | Human | Oral cavity | OSCC | 2.06e-04 | 2.37e-01 | 0.1679 |
83855 | KLF16 | C08 | Human | Oral cavity | OSCC | 5.87e-04 | 1.44e-01 | 0.1919 |
83855 | KLF16 | LN46 | Human | Oral cavity | OSCC | 4.44e-02 | 1.73e-01 | 0.1666 |
83855 | KLF16 | SYSMH1 | Human | Oral cavity | OSCC | 1.99e-06 | 1.99e-01 | 0.1127 |
83855 | KLF16 | SYSMH2 | Human | Oral cavity | OSCC | 1.79e-16 | 3.98e-01 | 0.2326 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
KLF16 | CD8TCM | Endometrium | ADJ | ELOVL6,CCDC77,NCEH1, etc. | 1.74e-01 | ![]() |
KLF16 | TFH | Lung | MIAC | KLRC2,AP005482.1,IFITM1, etc. | 1.67e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLF16 | SNV | Missense_Mutation | c.395N>T | p.Pro132Leu | p.P132L | Q9BXK1 | protein_coding | tolerated(0.39) | possibly_damaging(0.534) | TCGA-BC-A217-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KLF16 | SNV | Missense_Mutation | novel | c.724A>T | p.Ser242Cys | p.S242C | Q9BXK1 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-DD-AACI-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KLF16 | deletion | Frame_Shift_Del | novel | c.416delA | p.Tyr139SerfsTer6 | p.Y139Sfs*6 | Q9BXK1 | protein_coding | TCGA-G3-A25S-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sunitinib | PD | ||
KLF16 | SNV | Missense_Mutation | c.521N>C | p.Leu174Pro | p.L174P | Q9BXK1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-67-6215-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
KLF16 | SNV | Missense_Mutation | c.464N>A | p.Arg155His | p.R155H | Q9BXK1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KLF16 | SNV | Missense_Mutation | c.464N>A | p.Arg155His | p.R155H | Q9BXK1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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