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Gene: KHSRP |
Gene summary for KHSRP |
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Gene information | Species | Human | Gene symbol | KHSRP | Gene ID | 8570 |
Gene name | KH-type splicing regulatory protein | |
Gene Alias | FBP2 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | Q92945 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8570 | KHSRP | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.13e-06 | 3.08e-01 | 0.0155 |
8570 | KHSRP | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.97e-06 | 4.53e-01 | -0.1808 |
8570 | KHSRP | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.88e-08 | 5.27e-01 | -0.0811 |
8570 | KHSRP | HTA11_78_2000001011 | Human | Colorectum | AD | 1.05e-09 | 4.74e-01 | -0.1088 |
8570 | KHSRP | HTA11_347_2000001011 | Human | Colorectum | AD | 2.21e-23 | 6.52e-01 | -0.1954 |
8570 | KHSRP | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.53e-04 | 3.92e-01 | -0.1207 |
8570 | KHSRP | HTA11_83_2000001011 | Human | Colorectum | SER | 1.09e-05 | 4.38e-01 | -0.1526 |
8570 | KHSRP | HTA11_696_2000001011 | Human | Colorectum | AD | 1.81e-12 | 4.64e-01 | -0.1464 |
8570 | KHSRP | HTA11_866_2000001011 | Human | Colorectum | AD | 2.67e-14 | 4.67e-01 | -0.1001 |
8570 | KHSRP | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.74e-24 | 9.55e-01 | -0.059 |
8570 | KHSRP | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.68e-09 | 6.60e-01 | -0.1706 |
8570 | KHSRP | HTA11_546_2000001011 | Human | Colorectum | AD | 1.02e-08 | 5.38e-01 | -0.0842 |
8570 | KHSRP | HTA11_866_3004761011 | Human | Colorectum | AD | 1.03e-14 | 5.49e-01 | 0.096 |
8570 | KHSRP | HTA11_4255_2000001011 | Human | Colorectum | SER | 9.14e-05 | 6.86e-01 | 0.0446 |
8570 | KHSRP | HTA11_7663_2000001011 | Human | Colorectum | SER | 5.34e-07 | 6.81e-01 | 0.0131 |
8570 | KHSRP | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.86e-04 | 5.04e-01 | -0.0177 |
8570 | KHSRP | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.80e-05 | 4.36e-01 | 0.0338 |
8570 | KHSRP | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.23e-49 | 1.15e+00 | 0.0674 |
8570 | KHSRP | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.95e-04 | 5.27e-01 | 0.0112 |
8570 | KHSRP | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.13e-07 | 4.78e-01 | 0.0588 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
GO:0006401 | Colorectum | AD | RNA catabolic process | 102/3918 | 278/18723 | 8.64e-10 | 6.76e-08 | 102 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0006402 | Colorectum | AD | mRNA catabolic process | 87/3918 | 232/18723 | 4.40e-09 | 2.84e-07 | 87 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0061013 | Colorectum | AD | regulation of mRNA catabolic process | 64/3918 | 166/18723 | 1.44e-07 | 6.59e-06 | 64 |
GO:0043487 | Colorectum | AD | regulation of RNA stability | 63/3918 | 170/18723 | 9.17e-07 | 3.12e-05 | 63 |
GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
GO:0043488 | Colorectum | AD | regulation of mRNA stability | 59/3918 | 158/18723 | 1.50e-06 | 4.66e-05 | 59 |
GO:0006403 | Colorectum | AD | RNA localization | 71/3918 | 201/18723 | 1.54e-06 | 4.76e-05 | 71 |
GO:0051236 | Colorectum | AD | establishment of RNA localization | 58/3918 | 166/18723 | 1.95e-05 | 4.01e-04 | 58 |
GO:0015931 | Colorectum | AD | nucleobase-containing compound transport | 73/3918 | 222/18723 | 2.02e-05 | 4.10e-04 | 73 |
GO:0050657 | Colorectum | AD | nucleic acid transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KHSRP | SNV | Missense_Mutation | c.640N>T | p.Arg214Trp | p.R214W | Q92945 | protein_coding | deleterious(0) | probably_damaging(0.918) | TCGA-AA-3667-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KHSRP | SNV | Missense_Mutation | c.916N>T | p.Arg306Cys | p.R306C | Q92945 | protein_coding | deleterious(0.02) | probably_damaging(0.971) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
KHSRP | SNV | Missense_Mutation | rs758290639 | c.1223N>T | p.Pro408Leu | p.P408L | Q92945 | protein_coding | tolerated(0.58) | benign(0.034) | TCGA-AA-3851-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KHSRP | SNV | Missense_Mutation | novel | c.1433G>T | p.Arg478Leu | p.R478L | Q92945 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
KHSRP | SNV | Missense_Mutation | c.1281N>T | p.Met427Ile | p.M427I | Q92945 | protein_coding | tolerated(0.67) | benign(0.055) | TCGA-DM-A28F-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
KHSRP | SNV | Missense_Mutation | c.1459N>A | p.Ala487Thr | p.A487T | Q92945 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KHSRP | SNV | Missense_Mutation | c.275N>T | p.Ala92Val | p.A92V | Q92945 | protein_coding | tolerated(0.12) | benign(0.015) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
KHSRP | SNV | Missense_Mutation | c.1223N>G | p.Pro408Arg | p.P408R | Q92945 | protein_coding | tolerated(0.85) | benign(0.053) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
KHSRP | SNV | Missense_Mutation | c.1591N>T | p.Pro531Ser | p.P531S | Q92945 | protein_coding | tolerated(0.09) | benign(0.098) | TCGA-AH-6544-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
KHSRP | SNV | Missense_Mutation | c.941N>A | p.Arg314Gln | p.R314Q | Q92945 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8570 | KHSRP | NA | GO-Y030 | CHEMBL598509 |
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