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Gene: KDM4C |
Gene summary for KDM4C |
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Gene information | Species | Human | Gene symbol | KDM4C | Gene ID | 23081 |
Gene name | lysine demethylase 4C | |
Gene Alias | GASC1 | |
Cytomap | 9p24.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9H3R0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23081 | KDM4C | CCI_1 | Human | Cervix | CC | 5.66e-08 | 7.48e-01 | 0.528 |
23081 | KDM4C | CCI_2 | Human | Cervix | CC | 5.25e-17 | 1.31e+00 | 0.5249 |
23081 | KDM4C | CCI_3 | Human | Cervix | CC | 3.24e-13 | 7.70e-01 | 0.516 |
23081 | KDM4C | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.89e-53 | -1.14e+00 | 0.0155 |
23081 | KDM4C | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.84e-26 | -9.74e-01 | -0.1808 |
23081 | KDM4C | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.44e-09 | -1.13e+00 | 0.0216 |
23081 | KDM4C | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.55e-19 | -9.02e-01 | -0.0811 |
23081 | KDM4C | HTA11_78_2000001011 | Human | Colorectum | AD | 3.59e-16 | -7.77e-01 | -0.1088 |
23081 | KDM4C | HTA11_347_2000001011 | Human | Colorectum | AD | 2.52e-17 | -6.47e-01 | -0.1954 |
23081 | KDM4C | HTA11_411_2000001011 | Human | Colorectum | SER | 5.97e-03 | -8.29e-01 | -0.2602 |
23081 | KDM4C | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.79e-06 | -9.56e-01 | -0.2196 |
23081 | KDM4C | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.63e-27 | -1.13e+00 | -0.1207 |
23081 | KDM4C | HTA11_83_2000001011 | Human | Colorectum | SER | 5.04e-21 | -1.06e+00 | -0.1526 |
23081 | KDM4C | HTA11_696_2000001011 | Human | Colorectum | AD | 6.01e-60 | -1.03e+00 | -0.1464 |
23081 | KDM4C | HTA11_866_2000001011 | Human | Colorectum | AD | 1.05e-51 | -1.00e+00 | -0.1001 |
23081 | KDM4C | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.48e-32 | -9.82e-01 | -0.059 |
23081 | KDM4C | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.67e-08 | -9.45e-01 | -0.1706 |
23081 | KDM4C | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.40e-10 | -1.06e+00 | -0.2061 |
23081 | KDM4C | HTA11_5216_2000001011 | Human | Colorectum | SER | 9.57e-09 | -1.07e+00 | -0.1462 |
23081 | KDM4C | HTA11_546_2000001011 | Human | Colorectum | AD | 2.67e-18 | -1.03e+00 | -0.0842 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004854510 | Cervix | CC | response to steroid hormone | 74/2311 | 339/18723 | 5.71e-07 | 2.09e-05 | 74 |
GO:00305229 | Cervix | CC | intracellular receptor signaling pathway | 60/2311 | 265/18723 | 1.89e-06 | 5.97e-05 | 60 |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:00165705 | Cervix | CC | histone modification | 84/2311 | 463/18723 | 1.70e-04 | 2.01e-03 | 84 |
GO:00713839 | Cervix | CC | cellular response to steroid hormone stimulus | 40/2311 | 204/18723 | 1.93e-03 | 1.42e-02 | 40 |
GO:00305188 | Cervix | CC | intracellular steroid hormone receptor signaling pathway | 25/2311 | 116/18723 | 3.59e-03 | 2.30e-02 | 25 |
GO:00305218 | Cervix | CC | androgen receptor signaling pathway | 12/2311 | 44/18723 | 5.76e-03 | 3.30e-02 | 12 |
GO:00063381 | Cervix | CC | chromatin remodeling | 45/2311 | 255/18723 | 8.33e-03 | 4.30e-02 | 45 |
GO:0071383 | Colorectum | AD | cellular response to steroid hormone stimulus | 73/3918 | 204/18723 | 6.31e-07 | 2.24e-05 | 73 |
GO:0030522 | Colorectum | AD | intracellular receptor signaling pathway | 87/3918 | 265/18723 | 3.69e-06 | 1.03e-04 | 87 |
GO:0043401 | Colorectum | AD | steroid hormone mediated signaling pathway | 51/3918 | 136/18723 | 6.52e-06 | 1.63e-04 | 51 |
GO:0048545 | Colorectum | AD | response to steroid hormone | 104/3918 | 339/18723 | 1.33e-05 | 2.90e-04 | 104 |
GO:0009755 | Colorectum | AD | hormone-mediated signaling pathway | 64/3918 | 190/18723 | 2.78e-05 | 5.24e-04 | 64 |
GO:0030518 | Colorectum | AD | intracellular steroid hormone receptor signaling pathway | 43/3918 | 116/18723 | 4.61e-05 | 7.97e-04 | 43 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0030521 | Colorectum | AD | androgen receptor signaling pathway | 20/3918 | 44/18723 | 2.26e-04 | 2.94e-03 | 20 |
GO:0006338 | Colorectum | AD | chromatin remodeling | 70/3918 | 255/18723 | 7.44e-03 | 4.53e-02 | 70 |
GO:00713831 | Colorectum | SER | cellular response to steroid hormone stimulus | 55/2897 | 204/18723 | 1.66e-05 | 5.05e-04 | 55 |
GO:00485451 | Colorectum | SER | response to steroid hormone | 80/2897 | 339/18723 | 5.15e-05 | 1.25e-03 | 80 |
GO:00434011 | Colorectum | SER | steroid hormone mediated signaling pathway | 38/2897 | 136/18723 | 1.42e-04 | 2.82e-03 | 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KDM4C | deletion | Frame_Shift_Del | novel | c.1206delN | p.Asp404ThrfsTer17 | p.D404Tfs*17 | Q9H3R0 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
KDM4C | SNV | Missense_Mutation | novel | c.2219N>A | p.Gly740Glu | p.G740E | Q9H3R0 | protein_coding | tolerated(0.43) | benign(0.011) | TCGA-C5-A1M7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KDM4C | SNV | Missense_Mutation | novel | c.326G>T | p.Cys109Phe | p.C109F | Q9H3R0 | protein_coding | deleterious(0) | possibly_damaging(0.783) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
KDM4C | SNV | Missense_Mutation | novel | c.2693N>T | p.Arg898Ile | p.R898I | Q9H3R0 | protein_coding | deleterious(0.01) | benign(0.117) | TCGA-DG-A2KM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
KDM4C | SNV | Missense_Mutation | c.389N>C | p.Val130Ala | p.V130A | Q9H3R0 | protein_coding | tolerated(0.19) | possibly_damaging(0.682) | TCGA-DS-A0VM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
KDM4C | SNV | Missense_Mutation | c.3140N>G | p.Ser1047Cys | p.S1047C | Q9H3R0 | protein_coding | tolerated(0.08) | possibly_damaging(0.894) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
KDM4C | SNV | Missense_Mutation | c.1889N>T | p.Ala630Val | p.A630V | Q9H3R0 | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
KDM4C | SNV | Missense_Mutation | rs776521442 | c.2303N>T | p.Thr768Met | p.T768M | Q9H3R0 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KDM4C | SNV | Missense_Mutation | c.3107N>T | p.Ala1036Val | p.A1036V | Q9H3R0 | protein_coding | deleterious(0.02) | benign(0.036) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KDM4C | SNV | Missense_Mutation | novel | c.375G>T | p.Lys125Asn | p.K125N | Q9H3R0 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | PYROGALLOL RED | PYROGALLOL RED | ||
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | Pyrido[1,2-a]indole-1.-carboxylic acid analog 2 | |||
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | Pyrido[1,2-a]indole-1.-carboxylic acid analog 4 | |||
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | PYRIDINE-2,4-DICARBOXYLIC ACID | CHEMBL316034 | ||
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | SKF-38393 | SKF-38393 | ||
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | Pyrido[1,2-a]indole-1.-carboxylic acid analog 7 | |||
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | TYRPHOSTIN 23 | TYRPHOSTIN 23 | ||
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | PMID25468267-Compound-46 | |||
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | N-METHOXYCARBONYLMETHYL-OXALAMIC ACID METHYL ESTER | CHEMBL92309 | 19359167 | |
23081 | KDM4C | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | Pyrido[1,2-a]indole-1.-carboxylic acid analog 1 |
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