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Gene: KATNB1 |
Gene summary for KATNB1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | KATNB1 | Gene ID | 10300 |
Gene name | katanin regulatory subunit B1 | |
Gene Alias | KAT | |
Cytomap | 16q21 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q9BVA0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10300 | KATNB1 | LZE7T | Human | Esophagus | ESCC | 1.59e-04 | 2.62e-01 | 0.0667 |
10300 | KATNB1 | LZE8T | Human | Esophagus | ESCC | 1.92e-05 | 1.89e-01 | 0.067 |
10300 | KATNB1 | LZE24T | Human | Esophagus | ESCC | 1.99e-08 | 3.20e-01 | 0.0596 |
10300 | KATNB1 | P1T-E | Human | Esophagus | ESCC | 2.31e-04 | 2.73e-01 | 0.0875 |
10300 | KATNB1 | P2T-E | Human | Esophagus | ESCC | 1.23e-14 | 2.54e-01 | 0.1177 |
10300 | KATNB1 | P4T-E | Human | Esophagus | ESCC | 1.77e-11 | 3.35e-01 | 0.1323 |
10300 | KATNB1 | P8T-E | Human | Esophagus | ESCC | 2.61e-12 | 1.74e-01 | 0.0889 |
10300 | KATNB1 | P10T-E | Human | Esophagus | ESCC | 3.98e-13 | 1.17e-01 | 0.116 |
10300 | KATNB1 | P11T-E | Human | Esophagus | ESCC | 1.12e-07 | 2.86e-01 | 0.1426 |
10300 | KATNB1 | P12T-E | Human | Esophagus | ESCC | 5.23e-05 | 7.47e-02 | 0.1122 |
10300 | KATNB1 | P15T-E | Human | Esophagus | ESCC | 2.83e-06 | 8.88e-02 | 0.1149 |
10300 | KATNB1 | P16T-E | Human | Esophagus | ESCC | 3.50e-06 | 1.42e-01 | 0.1153 |
10300 | KATNB1 | P20T-E | Human | Esophagus | ESCC | 2.58e-14 | 3.25e-01 | 0.1124 |
10300 | KATNB1 | P21T-E | Human | Esophagus | ESCC | 4.59e-16 | 3.34e-01 | 0.1617 |
10300 | KATNB1 | P22T-E | Human | Esophagus | ESCC | 1.36e-11 | 1.99e-01 | 0.1236 |
10300 | KATNB1 | P23T-E | Human | Esophagus | ESCC | 4.34e-04 | 1.99e-01 | 0.108 |
10300 | KATNB1 | P24T-E | Human | Esophagus | ESCC | 3.85e-11 | 1.95e-01 | 0.1287 |
10300 | KATNB1 | P26T-E | Human | Esophagus | ESCC | 1.17e-12 | 2.73e-01 | 0.1276 |
10300 | KATNB1 | P27T-E | Human | Esophagus | ESCC | 2.27e-10 | 2.00e-01 | 0.1055 |
10300 | KATNB1 | P28T-E | Human | Esophagus | ESCC | 1.80e-03 | 1.25e-01 | 0.1149 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
GO:005130311 | Esophagus | ESCC | establishment of chromosome localization | 67/8552 | 80/18723 | 1.92e-12 | 8.09e-11 | 67 |
GO:005000011 | Esophagus | ESCC | chromosome localization | 68/8552 | 82/18723 | 3.37e-12 | 1.32e-10 | 68 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
GO:1902905111 | Esophagus | ESCC | positive regulation of supramolecular fiber organization | 142/8552 | 209/18723 | 5.51e-11 | 1.76e-09 | 142 |
GO:1902903111 | Esophagus | ESCC | regulation of supramolecular fiber organization | 237/8552 | 383/18723 | 9.06e-11 | 2.75e-09 | 237 |
GO:0010639110 | Esophagus | ESCC | negative regulation of organelle organization | 215/8552 | 348/18723 | 8.20e-10 | 2.01e-08 | 215 |
GO:005149520 | Esophagus | ESCC | positive regulation of cytoskeleton organization | 147/8552 | 226/18723 | 2.93e-09 | 6.38e-08 | 147 |
GO:00705078 | Esophagus | ESCC | regulation of microtubule cytoskeleton organization | 99/8552 | 148/18723 | 1.43e-07 | 2.29e-06 | 99 |
GO:003134616 | Esophagus | ESCC | positive regulation of cell projection organization | 201/8552 | 353/18723 | 1.19e-05 | 1.11e-04 | 201 |
GO:00311128 | Esophagus | ESCC | positive regulation of microtubule polymerization or depolymerization | 29/8552 | 37/18723 | 4.97e-05 | 3.86e-04 | 29 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KATNB1 | SNV | Missense_Mutation | c.440N>A | p.Ser147Asn | p.S147N | Q9BVA0 | protein_coding | tolerated(0.19) | benign(0.091) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
KATNB1 | SNV | Missense_Mutation | rs782208957 | c.1231G>A | p.Ala411Thr | p.A411T | Q9BVA0 | protein_coding | tolerated(0.62) | benign(0) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KATNB1 | SNV | Missense_Mutation | c.1060T>C | p.Ser354Pro | p.S354P | Q9BVA0 | protein_coding | tolerated(0.27) | benign(0) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KATNB1 | SNV | Missense_Mutation | c.1583N>A | p.Ala528Asp | p.A528D | Q9BVA0 | protein_coding | deleterious(0) | possibly_damaging(0.898) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
KATNB1 | SNV | Missense_Mutation | rs143811277 | c.1184C>T | p.Thr395Met | p.T395M | Q9BVA0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-DY-A0XA-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | mayo | CR |
KATNB1 | SNV | Missense_Mutation | rs552545792 | c.53N>T | p.Ala18Val | p.A18V | Q9BVA0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KATNB1 | SNV | Missense_Mutation | rs144107393 | c.1109G>A | p.Arg370His | p.R370H | Q9BVA0 | protein_coding | deleterious(0.01) | benign(0.293) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
KATNB1 | SNV | Missense_Mutation | novel | c.540N>T | p.Lys180Asn | p.K180N | Q9BVA0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
KATNB1 | SNV | Missense_Mutation | rs782421954 | c.101N>A | p.Arg34Gln | p.R34Q | Q9BVA0 | protein_coding | tolerated(0.1) | probably_damaging(0.997) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
KATNB1 | SNV | Missense_Mutation | rs781845628 | c.1675G>A | p.Val559Ile | p.V559I | Q9BVA0 | protein_coding | tolerated(0.72) | benign(0.011) | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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