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Gene: KANK4 |
Gene summary for KANK4 |
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Gene information | Species | Human | Gene symbol | KANK4 | Gene ID | 163782 |
Gene name | KN motif and ankyrin repeat domains 4 | |
Gene Alias | ANKRD38 | |
Cytomap | 1p31.3 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q5T7N3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
163782 | KANK4 | HCC1 | Human | Liver | HCC | 1.95e-11 | 2.42e+00 | 0.5336 |
163782 | KANK4 | HCC2 | Human | Liver | HCC | 1.14e-24 | 1.89e+00 | 0.5341 |
163782 | KANK4 | HCC5 | Human | Liver | HCC | 2.18e-15 | 1.17e+00 | 0.4932 |
163782 | KANK4 | S014 | Human | Liver | HCC | 5.58e-06 | 2.24e-01 | 0.2254 |
163782 | KANK4 | S015 | Human | Liver | HCC | 5.13e-04 | 2.59e-01 | 0.2375 |
163782 | KANK4 | S016 | Human | Liver | HCC | 1.76e-04 | 1.96e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004325422 | Liver | HCC | regulation of protein-containing complex assembly | 264/7958 | 428/18723 | 5.47e-16 | 4.39e-14 | 264 |
GO:005125822 | Liver | HCC | protein polymerization | 182/7958 | 297/18723 | 4.17e-11 | 1.58e-09 | 182 |
GO:190290322 | Liver | HCC | regulation of supramolecular fiber organization | 224/7958 | 383/18723 | 1.54e-10 | 5.33e-09 | 224 |
GO:000701522 | Liver | HCC | actin filament organization | 252/7958 | 442/18723 | 3.83e-10 | 1.25e-08 | 252 |
GO:001063912 | Liver | HCC | negative regulation of organelle organization | 204/7958 | 348/18723 | 7.67e-10 | 2.37e-08 | 204 |
GO:003253522 | Liver | HCC | regulation of cellular component size | 217/7958 | 383/18723 | 1.28e-08 | 3.14e-07 | 217 |
GO:003227122 | Liver | HCC | regulation of protein polymerization | 141/7958 | 233/18723 | 2.00e-08 | 4.72e-07 | 141 |
GO:003297022 | Liver | HCC | regulation of actin filament-based process | 222/7958 | 397/18723 | 3.81e-08 | 8.30e-07 | 222 |
GO:003295622 | Liver | HCC | regulation of actin cytoskeleton organization | 202/7958 | 358/18723 | 6.18e-08 | 1.29e-06 | 202 |
GO:003133312 | Liver | HCC | negative regulation of protein-containing complex assembly | 91/7958 | 141/18723 | 1.01e-07 | 1.98e-06 | 91 |
GO:000815422 | Liver | HCC | actin polymerization or depolymerization | 130/7958 | 218/18723 | 2.31e-07 | 4.14e-06 | 130 |
GO:003004122 | Liver | HCC | actin filament polymerization | 116/7958 | 191/18723 | 2.66e-07 | 4.68e-06 | 116 |
GO:011005322 | Liver | HCC | regulation of actin filament organization | 158/7958 | 278/18723 | 9.01e-07 | 1.37e-05 | 158 |
GO:003083212 | Liver | HCC | regulation of actin filament length | 113/7958 | 189/18723 | 1.16e-06 | 1.71e-05 | 113 |
GO:003083322 | Liver | HCC | regulation of actin filament polymerization | 104/7958 | 172/18723 | 1.46e-06 | 2.08e-05 | 104 |
GO:000806412 | Liver | HCC | regulation of actin polymerization or depolymerization | 112/7958 | 188/18723 | 1.65e-06 | 2.31e-05 | 112 |
GO:190290412 | Liver | HCC | negative regulation of supramolecular fiber organization | 90/7958 | 167/18723 | 1.90e-03 | 9.69e-03 | 90 |
GO:003227212 | Liver | HCC | negative regulation of protein polymerization | 46/7958 | 80/18723 | 4.81e-03 | 2.03e-02 | 46 |
GO:00514946 | Liver | HCC | negative regulation of cytoskeleton organization | 84/7958 | 163/18723 | 1.22e-02 | 4.43e-02 | 84 |
GO:003083712 | Liver | HCC | negative regulation of actin filament polymerization | 37/7958 | 65/18723 | 1.33e-02 | 4.77e-02 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KANK4 | SNV | Missense_Mutation | c.13N>A | p.Asp5Asn | p.D5N | Q5T7N3 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
KANK4 | SNV | Missense_Mutation | c.2356N>T | p.Arg786Cys | p.R786C | Q5T7N3 | protein_coding | deleterious(0) | benign(0.372) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KANK4 | SNV | Missense_Mutation | c.1068N>T | p.Leu356Phe | p.L356F | Q5T7N3 | protein_coding | deleterious(0) | possibly_damaging(0.503) | TCGA-AA-3854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KANK4 | SNV | Missense_Mutation | c.2591N>C | p.Ile864Thr | p.I864T | Q5T7N3 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
KANK4 | SNV | Missense_Mutation | rs139968342 | c.2375N>T | p.Ser792Leu | p.S792L | Q5T7N3 | protein_coding | tolerated(0.18) | benign(0.013) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KANK4 | SNV | Missense_Mutation | c.971N>T | p.Gly324Val | p.G324V | Q5T7N3 | protein_coding | tolerated(0.07) | probably_damaging(0.946) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
KANK4 | SNV | Missense_Mutation | novel | c.1783A>G | p.Lys595Glu | p.K595E | Q5T7N3 | protein_coding | deleterious(0) | possibly_damaging(0.611) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
KANK4 | SNV | Missense_Mutation | rs140099321 | c.1892N>T | p.Pro631Leu | p.P631L | Q5T7N3 | protein_coding | tolerated(0.07) | possibly_damaging(0.47) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KANK4 | SNV | Missense_Mutation | novel | c.52G>T | p.Asp18Tyr | p.D18Y | Q5T7N3 | protein_coding | deleterious(0) | possibly_damaging(0.466) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KANK4 | SNV | Missense_Mutation | rs777299965 | c.1579N>A | p.Asp527Asn | p.D527N | Q5T7N3 | protein_coding | tolerated(0.18) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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