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Gene: JUP |
Gene summary for JUP |
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Gene information | Species | Human | Gene symbol | JUP | Gene ID | 3728 |
Gene name | junction plakoglobin | |
Gene Alias | CTNNG | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0001508 | UniProtAcc | A0A0S2Z487 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3728 | JUP | CA_HPV_1 | Human | Cervix | CC | 2.27e-15 | -4.54e-01 | 0.0264 |
3728 | JUP | CA_HPV_3 | Human | Cervix | CC | 2.58e-02 | 2.68e-01 | 0.0414 |
3728 | JUP | N_HPV_1 | Human | Cervix | N_HPV | 7.83e-05 | -3.61e-01 | 0.0079 |
3728 | JUP | CCI_1 | Human | Cervix | CC | 2.14e-05 | 6.72e-01 | 0.528 |
3728 | JUP | CCI_3 | Human | Cervix | CC | 3.47e-03 | 6.41e-01 | 0.516 |
3728 | JUP | Tumor | Human | Cervix | CC | 1.42e-40 | 8.08e-01 | 0.1241 |
3728 | JUP | sample3 | Human | Cervix | CC | 1.13e-47 | 7.85e-01 | 0.1387 |
3728 | JUP | L1 | Human | Cervix | CC | 4.14e-12 | 4.55e-01 | 0.0802 |
3728 | JUP | T3 | Human | Cervix | CC | 7.08e-42 | 7.84e-01 | 0.1389 |
3728 | JUP | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.37e-40 | 9.97e-01 | 0.0155 |
3728 | JUP | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.28e-40 | 1.61e+00 | -0.1808 |
3728 | JUP | HTA11_2951_2000001011 | Human | Colorectum | AD | 9.47e-14 | 1.32e+00 | 0.0216 |
3728 | JUP | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.13e-34 | 1.42e+00 | -0.0811 |
3728 | JUP | HTA11_78_2000001011 | Human | Colorectum | AD | 2.23e-17 | 8.59e-01 | -0.1088 |
3728 | JUP | HTA11_347_2000001011 | Human | Colorectum | AD | 7.55e-59 | 1.38e+00 | -0.1954 |
3728 | JUP | HTA11_411_2000001011 | Human | Colorectum | SER | 7.64e-15 | 2.32e+00 | -0.2602 |
3728 | JUP | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.98e-19 | 1.83e+00 | -0.2196 |
3728 | JUP | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.87e-21 | 1.19e+00 | -0.1207 |
3728 | JUP | HTA11_83_2000001011 | Human | Colorectum | SER | 1.04e-28 | 1.29e+00 | -0.1526 |
3728 | JUP | HTA11_696_2000001011 | Human | Colorectum | AD | 7.71e-54 | 1.33e+00 | -0.1464 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001081010 | Cervix | CC | regulation of cell-substrate adhesion | 69/2311 | 221/18723 | 8.57e-14 | 5.69e-11 | 69 |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:003297010 | Cervix | CC | regulation of actin filament-based process | 96/2311 | 397/18723 | 4.00e-11 | 8.54e-09 | 96 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:00435884 | Cervix | CC | skin development | 71/2311 | 263/18723 | 8.04e-11 | 1.46e-08 | 71 |
GO:00725949 | Cervix | CC | establishment of protein localization to organelle | 99/2311 | 422/18723 | 1.23e-10 | 2.11e-08 | 99 |
GO:004578510 | Cervix | CC | positive regulation of cell adhesion | 101/2311 | 437/18723 | 1.96e-10 | 3.08e-08 | 101 |
GO:190382910 | Cervix | CC | positive regulation of cellular protein localization | 72/2311 | 276/18723 | 3.20e-10 | 4.46e-08 | 72 |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:001063210 | Cervix | CC | regulation of epithelial cell migration | 72/2311 | 292/18723 | 4.52e-09 | 4.43e-07 | 72 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:00019528 | Cervix | CC | regulation of cell-matrix adhesion | 40/2311 | 128/18723 | 1.32e-08 | 1.04e-06 | 40 |
GO:00071608 | Cervix | CC | cell-matrix adhesion | 60/2311 | 233/18723 | 1.58e-08 | 1.23e-06 | 60 |
GO:005122210 | Cervix | CC | positive regulation of protein transport | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:00301117 | Cervix | CC | regulation of Wnt signaling pathway | 76/2311 | 328/18723 | 3.05e-08 | 2.08e-06 | 76 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05412 | Colorectum | FAP | Arrhythmogenic right ventricular cardiomyopathy | 23/1404 | 77/8465 | 2.58e-03 | 1.19e-02 | 7.23e-03 | 23 |
hsa05202 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa054121 | Colorectum | FAP | Arrhythmogenic right ventricular cardiomyopathy | 23/1404 | 77/8465 | 2.58e-03 | 1.19e-02 | 7.23e-03 | 23 |
hsa052021 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa052215 | Esophagus | ESCC | Acute myeloid leukemia | 49/4205 | 67/8465 | 7.43e-05 | 3.07e-04 | 1.57e-04 | 49 |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0522113 | Esophagus | ESCC | Acute myeloid leukemia | 49/4205 | 67/8465 | 7.43e-05 | 3.07e-04 | 1.57e-04 | 49 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa05221 | Liver | HCC | Acute myeloid leukemia | 41/4020 | 67/8465 | 1.64e-02 | 3.90e-02 | 2.17e-02 | 41 |
hsa052211 | Liver | HCC | Acute myeloid leukemia | 41/4020 | 67/8465 | 1.64e-02 | 3.90e-02 | 2.17e-02 | 41 |
hsa052214 | Oral cavity | OSCC | Acute myeloid leukemia | 42/3704 | 67/8465 | 1.34e-03 | 3.75e-03 | 1.91e-03 | 42 |
hsa0522112 | Oral cavity | OSCC | Acute myeloid leukemia | 42/3704 | 67/8465 | 1.34e-03 | 3.75e-03 | 1.91e-03 | 42 |
hsa0522121 | Oral cavity | EOLP | Acute myeloid leukemia | 19/1218 | 67/8465 | 2.20e-03 | 7.32e-03 | 4.32e-03 | 19 |
hsa052213 | Oral cavity | EOLP | Acute myeloid leukemia | 19/1218 | 67/8465 | 2.20e-03 | 7.32e-03 | 4.32e-03 | 19 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
JUP | SNV | Missense_Mutation | c.349N>A | p.Ala117Thr | p.A117T | P14923 | protein_coding | tolerated(0.15) | benign(0.2) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
JUP | SNV | Missense_Mutation | c.590N>A | p.Ser197Asn | p.S197N | P14923 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
JUP | SNV | Missense_Mutation | c.938N>G | p.Gln313Arg | p.Q313R | P14923 | protein_coding | tolerated(0.51) | benign(0.086) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
JUP | SNV | Missense_Mutation | c.1608N>T | p.Gln536His | p.Q536H | P14923 | protein_coding | deleterious(0.04) | possibly_damaging(0.522) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
JUP | SNV | Missense_Mutation | c.866N>T | p.Thr289Ile | p.T289I | P14923 | protein_coding | deleterious(0.04) | probably_damaging(0.974) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
JUP | SNV | Missense_Mutation | c.337N>A | p.Leu113Met | p.L113M | P14923 | protein_coding | deleterious(0.02) | benign(0.011) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
JUP | SNV | Missense_Mutation | c.337C>A | p.Leu113Met | p.L113M | P14923 | protein_coding | deleterious(0.02) | benign(0.011) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
JUP | SNV | Missense_Mutation | c.1988N>A | p.Arg663His | p.R663H | P14923 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
JUP | SNV | Missense_Mutation | rs200690479 | c.2105G>A | p.Arg702His | p.R702H | P14923 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
JUP | SNV | Missense_Mutation | rs727504778 | c.1933G>A | p.Ala645Thr | p.A645T | P14923 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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