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Gene: ITPRIPL2 |
Gene summary for ITPRIPL2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ITPRIPL2 | Gene ID | 162073 |
Gene name | ITPRIP like 2 | |
Gene Alias | ITPRIPL2 | |
Cytomap | 16p12.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q3MIP1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
162073 | ITPRIPL2 | LZE20T | Human | Esophagus | ESCC | 2.01e-03 | 1.29e-01 | 0.0662 |
162073 | ITPRIPL2 | LZE24T | Human | Esophagus | ESCC | 3.22e-02 | 1.12e-01 | 0.0596 |
162073 | ITPRIPL2 | P1T-E | Human | Esophagus | ESCC | 5.36e-07 | 3.68e-01 | 0.0875 |
162073 | ITPRIPL2 | P2T-E | Human | Esophagus | ESCC | 1.75e-12 | 2.08e-01 | 0.1177 |
162073 | ITPRIPL2 | P4T-E | Human | Esophagus | ESCC | 9.35e-08 | 2.60e-01 | 0.1323 |
162073 | ITPRIPL2 | P5T-E | Human | Esophagus | ESCC | 1.88e-05 | 9.88e-02 | 0.1327 |
162073 | ITPRIPL2 | P8T-E | Human | Esophagus | ESCC | 3.05e-23 | 4.74e-01 | 0.0889 |
162073 | ITPRIPL2 | P9T-E | Human | Esophagus | ESCC | 4.36e-10 | 1.03e-01 | 0.1131 |
162073 | ITPRIPL2 | P10T-E | Human | Esophagus | ESCC | 3.76e-02 | 9.10e-02 | 0.116 |
162073 | ITPRIPL2 | P11T-E | Human | Esophagus | ESCC | 7.89e-10 | 3.48e-01 | 0.1426 |
162073 | ITPRIPL2 | P12T-E | Human | Esophagus | ESCC | 1.56e-12 | 3.21e-01 | 0.1122 |
162073 | ITPRIPL2 | P15T-E | Human | Esophagus | ESCC | 7.65e-11 | 2.05e-01 | 0.1149 |
162073 | ITPRIPL2 | P16T-E | Human | Esophagus | ESCC | 2.44e-05 | 7.42e-02 | 0.1153 |
162073 | ITPRIPL2 | P17T-E | Human | Esophagus | ESCC | 2.04e-05 | 1.90e-01 | 0.1278 |
162073 | ITPRIPL2 | P20T-E | Human | Esophagus | ESCC | 1.16e-19 | 4.82e-01 | 0.1124 |
162073 | ITPRIPL2 | P21T-E | Human | Esophagus | ESCC | 5.20e-10 | 1.06e-01 | 0.1617 |
162073 | ITPRIPL2 | P22T-E | Human | Esophagus | ESCC | 4.88e-08 | 1.22e-01 | 0.1236 |
162073 | ITPRIPL2 | P23T-E | Human | Esophagus | ESCC | 1.62e-12 | 5.14e-01 | 0.108 |
162073 | ITPRIPL2 | P24T-E | Human | Esophagus | ESCC | 3.16e-11 | 3.35e-01 | 0.1287 |
162073 | ITPRIPL2 | P26T-E | Human | Esophagus | ESCC | 4.17e-08 | 8.51e-02 | 0.1276 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITPRIPL2 | SNV | Missense_Mutation | novel | c.1058N>A | p.Arg353His | p.R353H | Q3MIP1 | protein_coding | deleterious(0.03) | probably_damaging(0.984) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ITPRIPL2 | SNV | Missense_Mutation | rs774527060 | c.1249N>T | p.Arg417Cys | p.R417C | Q3MIP1 | protein_coding | tolerated(0.05) | benign(0.006) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ITPRIPL2 | SNV | Missense_Mutation | novel | c.1351N>A | p.Leu451Ile | p.L451I | Q3MIP1 | protein_coding | deleterious(0.01) | probably_damaging(0.967) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ITPRIPL2 | SNV | Missense_Mutation | c.1453N>A | p.Asp485Asn | p.D485N | Q3MIP1 | protein_coding | tolerated(0.07) | possibly_damaging(0.715) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
ITPRIPL2 | SNV | Missense_Mutation | rs751568618 | c.995N>T | p.Ala332Val | p.A332V | Q3MIP1 | protein_coding | tolerated(0.08) | benign(0.16) | TCGA-AX-A1C4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ITPRIPL2 | SNV | Missense_Mutation | novel | c.1541N>A | p.Arg514His | p.R514H | Q3MIP1 | protein_coding | tolerated_low_confidence(0.07) | probably_damaging(0.996) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ITPRIPL2 | SNV | Missense_Mutation | novel | c.1147C>T | p.Arg383Cys | p.R383C | Q3MIP1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ITPRIPL2 | SNV | Missense_Mutation | novel | c.1024C>T | p.Arg342Cys | p.R342C | Q3MIP1 | protein_coding | deleterious(0) | possibly_damaging(0.894) | TCGA-EC-A1QX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | PD |
ITPRIPL2 | SNV | Missense_Mutation | novel | c.754N>A | p.Leu252Met | p.L252M | Q3MIP1 | protein_coding | tolerated(0.21) | benign(0.097) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ITPRIPL2 | SNV | Missense_Mutation | novel | c.1340G>A | p.Arg447Gln | p.R447Q | Q3MIP1 | protein_coding | tolerated(0.41) | benign(0.009) | TCGA-EO-A3AU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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