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Gene: IP6K2 |
Gene summary for IP6K2 |
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Gene information | Species | Human | Gene symbol | IP6K2 | Gene ID | 51447 |
Gene name | inositol hexakisphosphate kinase 2 | |
Gene Alias | IHPK2 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | B2RCP4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51447 | IP6K2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.76e-03 | 4.88e-01 | -0.0811 |
51447 | IP6K2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.01e-14 | 6.46e-01 | -0.1954 |
51447 | IP6K2 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.63e-03 | 4.07e-01 | -0.1464 |
51447 | IP6K2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.09e-06 | 5.46e-01 | 0.294 |
51447 | IP6K2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.15e-03 | 5.42e-01 | 0.281 |
51447 | IP6K2 | A002-C-010 | Human | Colorectum | FAP | 3.11e-02 | -1.35e-01 | 0.242 |
51447 | IP6K2 | A015-C-203 | Human | Colorectum | FAP | 5.06e-24 | -7.95e-02 | -0.1294 |
51447 | IP6K2 | A015-C-204 | Human | Colorectum | FAP | 1.53e-03 | -4.43e-02 | -0.0228 |
51447 | IP6K2 | A002-C-201 | Human | Colorectum | FAP | 4.32e-09 | -5.00e-02 | 0.0324 |
51447 | IP6K2 | A002-C-203 | Human | Colorectum | FAP | 8.36e-05 | -1.14e-01 | 0.2786 |
51447 | IP6K2 | A001-C-119 | Human | Colorectum | FAP | 3.33e-02 | -1.91e-01 | -0.1557 |
51447 | IP6K2 | A001-C-108 | Human | Colorectum | FAP | 4.10e-16 | -1.82e-01 | -0.0272 |
51447 | IP6K2 | A002-C-205 | Human | Colorectum | FAP | 3.00e-17 | -2.62e-01 | -0.1236 |
51447 | IP6K2 | A001-C-104 | Human | Colorectum | FAP | 2.06e-04 | -1.07e-01 | 0.0184 |
51447 | IP6K2 | A015-C-006 | Human | Colorectum | FAP | 8.01e-13 | -1.88e-01 | -0.0994 |
51447 | IP6K2 | A015-C-106 | Human | Colorectum | FAP | 6.26e-13 | -1.10e-01 | -0.0511 |
51447 | IP6K2 | A002-C-114 | Human | Colorectum | FAP | 1.71e-13 | -2.26e-01 | -0.1561 |
51447 | IP6K2 | A015-C-104 | Human | Colorectum | FAP | 5.28e-27 | -1.49e-01 | -0.1899 |
51447 | IP6K2 | A001-C-014 | Human | Colorectum | FAP | 1.77e-15 | -1.89e-01 | 0.0135 |
51447 | IP6K2 | A002-C-016 | Human | Colorectum | FAP | 1.08e-19 | -2.58e-01 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
GO:0001558 | Colorectum | AD | regulation of cell growth | 124/3918 | 414/18723 | 7.67e-06 | 1.86e-04 | 124 |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0045926 | Colorectum | AD | negative regulation of growth | 70/3918 | 249/18723 | 4.07e-03 | 2.83e-02 | 70 |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
GO:0045017 | Colorectum | AD | glycerolipid biosynthetic process | 69/3918 | 252/18723 | 8.33e-03 | 4.88e-02 | 69 |
GO:00160492 | Colorectum | MSS | cell growth | 123/3467 | 482/18723 | 7.15e-05 | 1.21e-03 | 123 |
GO:00060662 | Colorectum | MSS | alcohol metabolic process | 92/3467 | 353/18723 | 2.57e-04 | 3.46e-03 | 92 |
GO:00015582 | Colorectum | MSS | regulation of cell growth | 105/3467 | 414/18723 | 2.97e-04 | 3.90e-03 | 105 |
GO:00160493 | Colorectum | FAP | cell growth | 112/2622 | 482/18723 | 2.40e-08 | 2.30e-06 | 112 |
GO:00015583 | Colorectum | FAP | regulation of cell growth | 95/2622 | 414/18723 | 5.02e-07 | 2.61e-05 | 95 |
GO:0008654 | Colorectum | FAP | phospholipid biosynthetic process | 54/2622 | 253/18723 | 8.88e-04 | 9.08e-03 | 54 |
GO:00066502 | Colorectum | FAP | glycerophospholipid metabolic process | 62/2622 | 306/18723 | 1.54e-03 | 1.38e-02 | 62 |
GO:00066442 | Colorectum | FAP | phospholipid metabolic process | 74/2622 | 383/18723 | 2.24e-03 | 1.83e-02 | 74 |
GO:00060663 | Colorectum | FAP | alcohol metabolic process | 69/2622 | 353/18723 | 2.29e-03 | 1.85e-02 | 69 |
GO:0046474 | Colorectum | FAP | glycerophospholipid biosynthetic process | 44/2622 | 211/18723 | 3.98e-03 | 2.76e-02 | 44 |
GO:00156981 | Colorectum | FAP | inorganic anion transport | 38/2622 | 180/18723 | 5.73e-03 | 3.67e-02 | 38 |
GO:00450172 | Colorectum | FAP | glycerolipid biosynthetic process | 50/2622 | 252/18723 | 6.32e-03 | 3.95e-02 | 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04070 | Colorectum | CRC | Phosphatidylinositol signaling system | 25/1091 | 97/8465 | 4.27e-04 | 4.60e-03 | 3.12e-03 | 25 |
hsa040701 | Colorectum | CRC | Phosphatidylinositol signaling system | 25/1091 | 97/8465 | 4.27e-04 | 4.60e-03 | 3.12e-03 | 25 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IP6K2 | SNV | Missense_Mutation | c.1087N>C | p.Ser363Pro | p.S363P | Q9UHH9 | protein_coding | tolerated(0.27) | possibly_damaging(0.616) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IP6K2 | SNV | Missense_Mutation | rs372776558 | c.635N>A | p.Arg212His | p.R212H | Q9UHH9 | protein_coding | tolerated(0.59) | probably_damaging(0.963) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IP6K2 | SNV | Missense_Mutation | rs575264529 | c.397N>T | p.Arg133Cys | p.R133C | Q9UHH9 | protein_coding | deleterious(0.02) | possibly_damaging(0.72) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IP6K2 | SNV | Missense_Mutation | novel | c.95N>C | p.Val32Ala | p.V32A | Q9UHH9 | protein_coding | deleterious(0.01) | possibly_damaging(0.82) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IP6K2 | SNV | Missense_Mutation | rs200712199 | c.1120G>A | p.Ala374Thr | p.A374T | Q9UHH9 | protein_coding | tolerated(0.65) | benign(0.063) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
IP6K2 | SNV | Missense_Mutation | c.404N>G | p.His135Arg | p.H135R | Q9UHH9 | protein_coding | tolerated(0.17) | benign(0.031) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IP6K2 | SNV | Missense_Mutation | novel | c.1112N>T | p.Pro371Leu | p.P371L | Q9UHH9 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-AG-A014-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IP6K2 | SNV | Missense_Mutation | rs755349495 | c.1024N>A | p.Glu342Lys | p.E342K | Q9UHH9 | protein_coding | tolerated(0.18) | benign(0.009) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IP6K2 | SNV | Missense_Mutation | rs41276537 | c.640N>A | p.Glu214Lys | p.E214K | Q9UHH9 | protein_coding | tolerated(1) | benign(0.005) | TCGA-AJ-A3QS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
IP6K2 | SNV | Missense_Mutation | c.462N>T | p.Lys154Asn | p.K154N | Q9UHH9 | protein_coding | tolerated(0.48) | benign(0.015) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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