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Gene: INPP5J |
Gene summary for INPP5J |
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Gene information | Species | Human | Gene symbol | INPP5J | Gene ID | 27124 |
Gene name | inositol polyphosphate-5-phosphatase J | |
Gene Alias | INPP5 | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q15735 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27124 | INPP5J | Adj_PTCwithHT_6 | Human | Thyroid | HT | 5.67e-05 | -2.47e-01 | 0.02 |
27124 | INPP5J | male-WTA | Human | Thyroid | PTC | 2.10e-29 | 3.12e-01 | 0.1037 |
27124 | INPP5J | PTC01 | Human | Thyroid | PTC | 5.03e-10 | 3.58e-01 | 0.1899 |
27124 | INPP5J | PTC04 | Human | Thyroid | PTC | 4.78e-12 | 3.87e-01 | 0.1927 |
27124 | INPP5J | PTC05 | Human | Thyroid | PTC | 4.01e-11 | 4.94e-01 | 0.2065 |
27124 | INPP5J | PTC06 | Human | Thyroid | PTC | 3.38e-17 | 5.44e-01 | 0.2057 |
27124 | INPP5J | PTC07 | Human | Thyroid | PTC | 4.20e-19 | 4.65e-01 | 0.2044 |
27124 | INPP5J | ATC12 | Human | Thyroid | ATC | 1.21e-04 | -2.53e-01 | 0.34 |
27124 | INPP5J | ATC13 | Human | Thyroid | ATC | 3.13e-03 | -2.33e-01 | 0.34 |
27124 | INPP5J | ATC4 | Human | Thyroid | ATC | 9.61e-03 | -2.53e-01 | 0.34 |
27124 | INPP5J | ATC5 | Human | Thyroid | ATC | 1.08e-02 | -2.34e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000193327 | Thyroid | HT | negative regulation of protein phosphorylation | 45/1272 | 342/18723 | 1.54e-05 | 3.80e-04 | 45 |
GO:004232627 | Thyroid | HT | negative regulation of phosphorylation | 49/1272 | 385/18723 | 1.62e-05 | 3.95e-04 | 49 |
GO:004593629 | Thyroid | HT | negative regulation of phosphate metabolic process | 54/1272 | 441/18723 | 1.86e-05 | 4.39e-04 | 54 |
GO:001056329 | Thyroid | HT | negative regulation of phosphorus metabolic process | 54/1272 | 442/18723 | 1.99e-05 | 4.60e-04 | 54 |
GO:190290330 | Thyroid | HT | regulation of supramolecular fiber organization | 47/1272 | 383/18723 | 6.02e-05 | 1.13e-03 | 47 |
GO:003133327 | Thyroid | HT | negative regulation of protein-containing complex assembly | 23/1272 | 141/18723 | 7.64e-05 | 1.37e-03 | 23 |
GO:004325430 | Thyroid | HT | regulation of protein-containing complex assembly | 50/1272 | 428/18723 | 1.24e-04 | 2.00e-03 | 50 |
GO:001097519 | Thyroid | HT | regulation of neuron projection development | 50/1272 | 445/18723 | 3.18e-04 | 4.18e-03 | 50 |
GO:001063925 | Thyroid | HT | negative regulation of organelle organization | 39/1272 | 348/18723 | 1.45e-03 | 1.36e-02 | 39 |
GO:005125828 | Thyroid | HT | protein polymerization | 34/1272 | 297/18723 | 1.99e-03 | 1.77e-02 | 34 |
GO:190290420 | Thyroid | HT | negative regulation of supramolecular fiber organization | 22/1272 | 167/18723 | 2.14e-03 | 1.87e-02 | 22 |
GO:003111310 | Thyroid | HT | regulation of microtubule polymerization | 10/1272 | 55/18723 | 3.57e-03 | 2.73e-02 | 10 |
GO:003227128 | Thyroid | HT | regulation of protein polymerization | 27/1272 | 233/18723 | 4.64e-03 | 3.28e-02 | 27 |
GO:007050710 | Thyroid | HT | regulation of microtubule cytoskeleton organization | 19/1272 | 148/18723 | 5.50e-03 | 3.62e-02 | 19 |
GO:1902903113 | Thyroid | PTC | regulation of supramolecular fiber organization | 202/5968 | 383/18723 | 1.16e-17 | 1.15e-15 | 202 |
GO:0043254113 | Thyroid | PTC | regulation of protein-containing complex assembly | 215/5968 | 428/18723 | 1.23e-15 | 9.09e-14 | 215 |
GO:0010563113 | Thyroid | PTC | negative regulation of phosphorus metabolic process | 219/5968 | 442/18723 | 4.47e-15 | 3.07e-13 | 219 |
GO:0045936113 | Thyroid | PTC | negative regulation of phosphate metabolic process | 218/5968 | 441/18723 | 7.08e-15 | 4.75e-13 | 218 |
GO:0001933113 | Thyroid | PTC | negative regulation of protein phosphorylation | 173/5968 | 342/18723 | 3.46e-13 | 1.75e-11 | 173 |
GO:0051258113 | Thyroid | PTC | protein polymerization | 154/5968 | 297/18723 | 5.35e-13 | 2.66e-11 | 154 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
INPP5J | SNV | Missense_Mutation | novel | c.2752N>T | p.Arg918Cys | p.R918C | Q15735 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.65) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
INPP5J | SNV | Missense_Mutation | c.95C>T | p.Ala32Val | p.A32V | Q15735 | protein_coding | tolerated_low_confidence(0.08) | benign(0.024) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
INPP5J | SNV | Missense_Mutation | c.2203A>G | p.Arg735Gly | p.R735G | Q15735 | protein_coding | deleterious(0.01) | possibly_damaging(0.632) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
INPP5J | SNV | Missense_Mutation | rs374379847 | c.2042N>A | p.Arg681His | p.R681H | Q15735 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
INPP5J | SNV | Missense_Mutation | c.1807N>A | p.Asp603Asn | p.D603N | Q15735 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
INPP5J | SNV | Missense_Mutation | c.1642N>A | p.Ala548Thr | p.A548T | Q15735 | protein_coding | tolerated(0.2) | benign(0.077) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
INPP5J | SNV | Missense_Mutation | rs369582455 | c.1819C>T | p.Arg607Cys | p.R607C | Q15735 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
INPP5J | SNV | Missense_Mutation | novel | c.1432N>A | p.Leu478Ile | p.L478I | Q15735 | protein_coding | tolerated(0.11) | benign(0.266) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
INPP5J | SNV | Missense_Mutation | novel | c.242C>A | p.Ser81Tyr | p.S81Y | Q15735 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.979) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
INPP5J | SNV | Missense_Mutation | novel | c.1216C>A | p.Leu406Met | p.L406M | Q15735 | protein_coding | deleterious_low_confidence(0.01) | benign(0.059) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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