![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: INPP1 |
Gene summary for INPP1 |
![]() |
Gene information | Species | Human | Gene symbol | INPP1 | Gene ID | 3628 |
Gene name | inositol polyphosphate-1-phosphatase | |
Gene Alias | INPP1 | |
Cytomap | 2q32.2 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | P49441 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3628 | INPP1 | CCI_2 | Human | Cervix | CC | 1.00e-07 | 9.06e-01 | 0.5249 |
3628 | INPP1 | CCI_3 | Human | Cervix | CC | 3.43e-10 | 7.90e-01 | 0.516 |
3628 | INPP1 | Tumor | Human | Cervix | CC | 1.42e-22 | 5.29e-01 | 0.1241 |
3628 | INPP1 | sample1 | Human | Cervix | CC | 2.11e-03 | 3.54e-01 | 0.0959 |
3628 | INPP1 | sample3 | Human | Cervix | CC | 2.11e-20 | 5.04e-01 | 0.1387 |
3628 | INPP1 | T1 | Human | Cervix | CC | 8.73e-06 | 3.01e-01 | 0.0918 |
3628 | INPP1 | T3 | Human | Cervix | CC | 1.41e-23 | 5.50e-01 | 0.1389 |
3628 | INPP1 | LZE8T | Human | Esophagus | ESCC | 2.28e-08 | 3.36e-01 | 0.067 |
3628 | INPP1 | LZE20T | Human | Esophagus | ESCC | 2.99e-03 | 2.16e-01 | 0.0662 |
3628 | INPP1 | LZE24T | Human | Esophagus | ESCC | 5.98e-05 | 1.69e-01 | 0.0596 |
3628 | INPP1 | P1T-E | Human | Esophagus | ESCC | 1.24e-04 | 4.54e-01 | 0.0875 |
3628 | INPP1 | P2T-E | Human | Esophagus | ESCC | 3.89e-34 | 6.07e-01 | 0.1177 |
3628 | INPP1 | P4T-E | Human | Esophagus | ESCC | 1.28e-11 | 4.49e-01 | 0.1323 |
3628 | INPP1 | P5T-E | Human | Esophagus | ESCC | 4.39e-16 | 2.57e-01 | 0.1327 |
3628 | INPP1 | P8T-E | Human | Esophagus | ESCC | 5.49e-37 | 6.92e-01 | 0.0889 |
3628 | INPP1 | P9T-E | Human | Esophagus | ESCC | 7.39e-13 | 2.97e-01 | 0.1131 |
3628 | INPP1 | P10T-E | Human | Esophagus | ESCC | 1.38e-02 | 9.63e-02 | 0.116 |
3628 | INPP1 | P11T-E | Human | Esophagus | ESCC | 2.24e-22 | 1.08e+00 | 0.1426 |
3628 | INPP1 | P12T-E | Human | Esophagus | ESCC | 2.19e-21 | 3.48e-01 | 0.1122 |
3628 | INPP1 | P16T-E | Human | Esophagus | ESCC | 6.11e-09 | 1.08e-01 | 0.1153 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00163117 | Cervix | CC | dephosphorylation | 73/2311 | 417/18723 | 1.23e-03 | 9.87e-03 | 73 |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:00086544 | Esophagus | ESCC | phospholipid biosynthetic process | 162/8552 | 253/18723 | 2.59e-09 | 5.73e-08 | 162 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:00464744 | Esophagus | ESCC | glycerophospholipid biosynthetic process | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:00450175 | Esophagus | ESCC | glycerolipid biosynthetic process | 154/8552 | 252/18723 | 5.20e-07 | 6.96e-06 | 154 |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
GO:00060668 | Esophagus | ESCC | alcohol metabolic process | 202/8552 | 353/18723 | 7.32e-06 | 7.26e-05 | 202 |
GO:00066505 | Esophagus | ESCC | glycerophospholipid metabolic process | 174/8552 | 306/18723 | 4.92e-05 | 3.85e-04 | 174 |
GO:00442626 | Esophagus | ESCC | cellular carbohydrate metabolic process | 160/8552 | 283/18723 | 1.43e-04 | 9.66e-04 | 160 |
GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
GO:00442827 | Esophagus | ESCC | small molecule catabolic process | 201/8552 | 376/18723 | 1.35e-03 | 6.41e-03 | 201 |
GO:00066611 | Esophagus | ESCC | phosphatidylinositol biosynthetic process | 73/8552 | 131/18723 | 1.31e-02 | 4.28e-02 | 73 |
GO:004428221 | Liver | HCC | small molecule catabolic process | 225/7958 | 376/18723 | 6.50e-12 | 2.80e-10 | 225 |
GO:000606621 | Liver | HCC | alcohol metabolic process | 208/7958 | 353/18723 | 2.80e-10 | 9.50e-09 | 208 |
GO:00086542 | Liver | HCC | phospholipid biosynthetic process | 150/7958 | 253/18723 | 4.77e-08 | 1.03e-06 | 150 |
GO:00066444 | Liver | HCC | phospholipid metabolic process | 214/7958 | 383/18723 | 7.25e-08 | 1.48e-06 | 214 |
GO:001631121 | Liver | HCC | dephosphorylation | 230/7958 | 417/18723 | 1.00e-07 | 1.96e-06 | 230 |
GO:000647021 | Liver | HCC | protein dephosphorylation | 162/7958 | 281/18723 | 1.91e-07 | 3.46e-06 | 162 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
INPP1 | SNV | Missense_Mutation | c.650N>A | p.Gly217Glu | p.G217E | P49441 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
INPP1 | SNV | Missense_Mutation | c.587N>T | p.Pro196Leu | p.P196L | P49441 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6627-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
INPP1 | insertion | Frame_Shift_Ins | novel | c.840_841dupTG | p.Gly281ValfsTer45 | p.G281Vfs*45 | P49441 | protein_coding | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
INPP1 | insertion | Frame_Shift_Ins | novel | c.151_152insCT | p.Leu52ArgfsTer11 | p.L52Rfs*11 | P49441 | protein_coding | TCGA-AA-A03F-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
INPP1 | SNV | Missense_Mutation | rs755770972 | c.848N>A | p.Arg283His | p.R283H | P49441 | protein_coding | tolerated(0.13) | benign(0.394) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
INPP1 | SNV | Missense_Mutation | c.1177G>A | p.Ala393Thr | p.A393T | P49441 | protein_coding | tolerated_low_confidence(0.09) | benign(0) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
INPP1 | SNV | Missense_Mutation | novel | c.863C>T | p.Ala288Val | p.A288V | P49441 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
INPP1 | SNV | Missense_Mutation | novel | c.1019N>T | p.Arg340Ile | p.R340I | P49441 | protein_coding | deleterious(0.03) | benign(0.292) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
INPP1 | SNV | Missense_Mutation | novel | c.46N>A | p.Ala16Thr | p.A16T | P49441 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AX-A3G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
INPP1 | SNV | Missense_Mutation | novel | c.690G>A | p.Met230Ile | p.M230I | P49441 | protein_coding | tolerated(1) | benign(0) | TCGA-AX-A3G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3628 | INPP1 | ENZYME | LITHIUM | LITHIUM | 16787706 |
Page: 1 |