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Gene: INMT |
Gene summary for INMT |
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Gene information | Species | Human | Gene symbol | INMT | Gene ID | 11185 |
Gene name | indolethylamine N-methyltransferase | |
Gene Alias | TEMT | |
Cytomap | 7p14.3 | |
Gene Type | protein-coding | GO ID | GO:0006807 | UniProtAcc | O95050 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11185 | INMT | male-WTA | Human | Thyroid | PTC | 4.37e-34 | 5.95e-01 | 0.1037 |
11185 | INMT | PTC01 | Human | Thyroid | PTC | 1.61e-39 | 1.21e+00 | 0.1899 |
11185 | INMT | PTC05 | Human | Thyroid | PTC | 5.53e-08 | 1.07e+00 | 0.2065 |
11185 | INMT | PTC06 | Human | Thyroid | PTC | 1.64e-53 | 2.22e+00 | 0.2057 |
11185 | INMT | PTC07 | Human | Thyroid | PTC | 1.49e-67 | 2.15e+00 | 0.2044 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009636111 | Thyroid | PTC | response to toxic substance | 115/5968 | 262/18723 | 2.70e-05 | 2.63e-04 | 115 |
GO:00322594 | Thyroid | PTC | methylation | 146/5968 | 364/18723 | 4.99e-04 | 3.26e-03 | 146 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
INMT | SNV | Missense_Mutation | novel | c.187G>A | p.Gly63Ser | p.G63S | O95050 | protein_coding | deleterious(0.04) | probably_damaging(0.98) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
INMT | SNV | Missense_Mutation | rs867912295 | c.49C>T | p.Pro17Ser | p.P17S | O95050 | protein_coding | tolerated(0.05) | probably_damaging(0.925) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
INMT | SNV | Missense_Mutation | novel | c.474N>A | p.Asp158Glu | p.D158E | O95050 | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
INMT | SNV | Missense_Mutation | novel | c.92N>A | p.Pro31His | p.P31H | O95050 | protein_coding | tolerated(0.52) | benign(0.003) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
INMT | SNV | Missense_Mutation | c.238G>T | p.Asp80Tyr | p.D80Y | O95050 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
INMT | SNV | Missense_Mutation | novel | c.649G>A | p.Glu217Lys | p.E217K | O95050 | protein_coding | tolerated(0.4) | benign(0.029) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
INMT | SNV | Missense_Mutation | c.55N>T | p.Asp19Tyr | p.D19Y | O95050 | protein_coding | deleterious(0.01) | possibly_damaging(0.88) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR | |
INMT | SNV | Missense_Mutation | novel | c.372N>T | p.Trp124Cys | p.W124C | O95050 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
INMT | SNV | Missense_Mutation | c.247N>G | p.Leu83Val | p.L83V | O95050 | protein_coding | tolerated(0.92) | benign(0.003) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
INMT | SNV | Missense_Mutation | c.305N>A | p.Pro102Gln | p.P102Q | O95050 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-86-7713-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | etoposide | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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