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Gene: IL13RA2 |
Gene summary for IL13RA2 |
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Gene information | Species | Human | Gene symbol | IL13RA2 | Gene ID | 3598 |
Gene name | interleukin 13 receptor subunit alpha 2 | |
Gene Alias | CD213A2 | |
Cytomap | Xq23 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q14627 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3598 | IL13RA2 | ATC09 | Human | Thyroid | ATC | 1.71e-46 | 2.54e+00 | 0.2871 |
3598 | IL13RA2 | ATC12 | Human | Thyroid | ATC | 4.82e-02 | 1.82e-01 | 0.34 |
3598 | IL13RA2 | ATC13 | Human | Thyroid | ATC | 1.84e-32 | 6.14e-01 | 0.34 |
3598 | IL13RA2 | ATC1 | Human | Thyroid | ATC | 1.64e-48 | 2.72e+00 | 0.2878 |
3598 | IL13RA2 | ATC4 | Human | Thyroid | ATC | 1.21e-03 | 2.36e-01 | 0.34 |
3598 | IL13RA2 | ATC5 | Human | Thyroid | ATC | 1.84e-32 | 6.69e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005165625 | Thyroid | ATC | establishment of organelle localization | 206/6293 | 390/18723 | 2.62e-15 | 1.84e-13 | 206 |
GO:005105114 | Thyroid | ATC | negative regulation of transport | 183/6293 | 470/18723 | 8.12e-03 | 3.13e-02 | 183 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IL13RA2 | SNV | Missense_Mutation | c.277N>T | p.Asp93Tyr | p.D93Y | Q14627 | protein_coding | tolerated(0.35) | benign(0.036) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IL13RA2 | SNV | Missense_Mutation | rs377163094 | c.221N>A | p.Arg74Gln | p.R74Q | Q14627 | protein_coding | deleterious(0) | benign(0.366) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IL13RA2 | SNV | Missense_Mutation | c.1128N>G | p.Phe376Leu | p.F376L | Q14627 | protein_coding | deleterious_low_confidence(0) | benign(0.001) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
IL13RA2 | SNV | Missense_Mutation | c.317A>G | p.His106Arg | p.H106R | Q14627 | protein_coding | tolerated(0.41) | benign(0.003) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IL13RA2 | SNV | Missense_Mutation | c.308N>T | p.Ala103Val | p.A103V | Q14627 | protein_coding | tolerated(0.54) | benign(0.017) | TCGA-AG-A00C-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
IL13RA2 | SNV | Missense_Mutation | c.625G>T | p.Asp209Tyr | p.D209Y | Q14627 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
IL13RA2 | SNV | Missense_Mutation | rs782749009 | c.1028N>A | p.Arg343His | p.R343H | Q14627 | protein_coding | tolerated(0.52) | benign(0.006) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IL13RA2 | SNV | Missense_Mutation | c.1024C>A | p.Leu342Ile | p.L342I | Q14627 | protein_coding | tolerated(0.94) | benign(0.017) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IL13RA2 | SNV | Missense_Mutation | c.887N>C | p.Lys296Thr | p.K296T | Q14627 | protein_coding | tolerated(0.1) | benign(0.015) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
IL13RA2 | SNV | Missense_Mutation | novel | c.94N>T | p.Val32Phe | p.V32F | Q14627 | protein_coding | deleterious(0) | possibly_damaging(0.906) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3598 | IL13RA2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | Tralokinumab | TRALOKINUMAB | ||
3598 | IL13RA2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | AER001,AEROVANT | |||
3598 | IL13RA2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | CHEMBL2108583 | CINTREDEKIN BESUDOTOX | ||
3598 | IL13RA2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | ICT-107 | |||
3598 | IL13RA2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | CINTREDEKIN BESUDOTOX | |||
3598 | IL13RA2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | ABT-308 | CENDAKIMAB | ||
3598 | IL13RA2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | MB-101 |
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