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Gene: IKZF5 |
Gene summary for IKZF5 |
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Gene information | Species | Human | Gene symbol | IKZF5 | Gene ID | 64376 |
Gene name | IKAROS family zinc finger 5 | |
Gene Alias | PEGASUS | |
Cytomap | 10q26.13 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9H5V7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64376 | IKZF5 | HCC1_Meng | Human | Liver | HCC | 5.26e-13 | -4.42e-02 | 0.0246 |
64376 | IKZF5 | HCC2_Meng | Human | Liver | HCC | 3.17e-07 | -3.54e-03 | 0.0107 |
64376 | IKZF5 | HCC1 | Human | Liver | HCC | 4.69e-02 | 2.41e+00 | 0.5336 |
64376 | IKZF5 | HCC2 | Human | Liver | HCC | 4.09e-05 | 2.33e+00 | 0.5341 |
64376 | IKZF5 | S016 | Human | Liver | HCC | 2.16e-02 | 1.99e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IKZF5 | SNV | Missense_Mutation | c.479N>G | p.Lys160Arg | p.K160R | Q9H5V7 | protein_coding | tolerated(1) | benign(0.001) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IKZF5 | SNV | Missense_Mutation | novel | c.368G>A | p.Arg123His | p.R123H | Q9H5V7 | protein_coding | deleterious(0.04) | benign(0.048) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IKZF5 | deletion | Frame_Shift_Del | c.15delN | p.Lys5AsnfsTer8 | p.K5Nfs*8 | Q9H5V7 | protein_coding | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |||
IKZF5 | deletion | Frame_Shift_Del | c.15delA | p.Lys5AsnfsTer8 | p.K5Nfs*8 | Q9H5V7 | protein_coding | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |||
IKZF5 | deletion | Frame_Shift_Del | c.15delN | p.Lys5AsnfsTer8 | p.K5Nfs*8 | Q9H5V7 | protein_coding | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
IKZF5 | deletion | Frame_Shift_Del | c.15delN | p.Lys5AsnfsTer8 | p.K5Nfs*8 | Q9H5V7 | protein_coding | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
IKZF5 | SNV | Missense_Mutation | novel | c.847N>A | p.Glu283Lys | p.E283K | Q9H5V7 | protein_coding | tolerated(0.06) | probably_damaging(0.985) | TCGA-4E-A92E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IKZF5 | SNV | Missense_Mutation | novel | c.1055N>A | p.Ala352Asp | p.A352D | Q9H5V7 | protein_coding | tolerated(0.08) | benign(0.086) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
IKZF5 | SNV | Missense_Mutation | c.1087N>A | p.Leu363Met | p.L363M | Q9H5V7 | protein_coding | tolerated(0.08) | benign(0.142) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IKZF5 | SNV | Missense_Mutation | c.403N>A | p.Glu135Lys | p.E135K | Q9H5V7 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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