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Gene: IGHA1 |
Gene summary for IGHA1 |
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Gene information | Species | Human | Gene symbol | IGHA1 | Gene ID | 3493 |
Gene name | immunoglobulin heavy constant alpha 1 | |
Gene Alias | IgA1 | |
Cytomap | 14q32.33 | |
Gene Type | other | GO ID | GO:0001775 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3493 | IGHA1 | CA_HPV_1 | Human | Cervix | CC | 1.35e-66 | -1.51e+00 | 0.0264 |
3493 | IGHA1 | CA_HPV_2 | Human | Cervix | CC | 6.59e-80 | -1.60e+00 | 0.0391 |
3493 | IGHA1 | CA_HPV_3 | Human | Cervix | CC | 5.86e-60 | -1.53e+00 | 0.0414 |
3493 | IGHA1 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 2.77e-32 | -1.23e+00 | 0.0116 |
3493 | IGHA1 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 3.23e-31 | -9.70e-01 | 0.0208 |
3493 | IGHA1 | N_HPV_1 | Human | Cervix | N_HPV | 2.25e-16 | -7.67e-01 | 0.0079 |
3493 | IGHA1 | N_HPV_2 | Human | Cervix | N_HPV | 3.98e-78 | -1.59e+00 | -0.0131 |
3493 | IGHA1 | CCI_1 | Human | Cervix | CC | 4.05e-30 | -1.66e+00 | 0.528 |
3493 | IGHA1 | CCI_2 | Human | Cervix | CC | 4.11e-28 | -1.66e+00 | 0.5249 |
3493 | IGHA1 | CCI_3 | Human | Cervix | CC | 4.38e-38 | -1.66e+00 | 0.516 |
3493 | IGHA1 | CCII_1 | Human | Cervix | CC | 5.65e-50 | -1.66e+00 | 0.3249 |
3493 | IGHA1 | Tumor | Human | Cervix | CC | 1.01e-90 | -1.66e+00 | 0.1241 |
3493 | IGHA1 | sample1 | Human | Cervix | CC | 4.98e-43 | -1.66e+00 | 0.0959 |
3493 | IGHA1 | sample3 | Human | Cervix | CC | 1.69e-85 | -1.65e+00 | 0.1387 |
3493 | IGHA1 | H2 | Human | Cervix | HSIL_HPV | 5.44e-66 | -1.47e+00 | 0.0632 |
3493 | IGHA1 | L1 | Human | Cervix | CC | 9.32e-46 | -1.60e+00 | 0.0802 |
3493 | IGHA1 | T1 | Human | Cervix | CC | 1.50e-77 | -1.61e+00 | 0.0918 |
3493 | IGHA1 | T2 | Human | Cervix | CC | 1.72e-17 | -1.37e+00 | 0.0709 |
3493 | IGHA1 | T3 | Human | Cervix | CC | 2.92e-80 | -1.63e+00 | 0.1389 |
3493 | IGHA1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 6.26e-26 | 1.49e+00 | 0.0216 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00027644 | Cervix | CC | immune response-regulating signaling pathway | 97/2311 | 468/18723 | 1.49e-07 | 7.07e-06 | 97 |
GO:00018949 | Cervix | CC | tissue homeostasis | 57/2311 | 268/18723 | 2.43e-05 | 4.21e-04 | 57 |
GO:00602498 | Cervix | CC | anatomical structure homeostasis | 63/2311 | 314/18723 | 6.03e-05 | 8.68e-04 | 63 |
GO:00457306 | Cervix | CC | respiratory burst | 14/2311 | 37/18723 | 6.97e-05 | 9.81e-04 | 14 |
GO:00022533 | Cervix | CC | activation of immune response | 72/2311 | 375/18723 | 8.26e-05 | 1.11e-03 | 72 |
GO:0002768 | Cervix | CC | immune response-regulating cell surface receptor signaling pathway | 59/2311 | 315/18723 | 6.64e-04 | 6.11e-03 | 59 |
GO:00026967 | Cervix | CC | positive regulation of leukocyte activation | 72/2311 | 409/18723 | 1.13e-03 | 9.31e-03 | 72 |
GO:00512516 | Cervix | CC | positive regulation of lymphocyte activation | 65/2311 | 362/18723 | 1.15e-03 | 9.39e-03 | 65 |
GO:00508676 | Cervix | CC | positive regulation of cell activation | 73/2311 | 420/18723 | 1.50e-03 | 1.16e-02 | 73 |
GO:00197308 | Cervix | CC | antimicrobial humoral response | 27/2311 | 122/18723 | 1.70e-03 | 1.29e-02 | 27 |
GO:00602634 | Cervix | CC | regulation of respiratory burst | 7/2311 | 17/18723 | 2.72e-03 | 1.85e-02 | 7 |
GO:00018957 | Cervix | CC | retina homeostasis | 19/2311 | 79/18723 | 2.94e-03 | 1.94e-02 | 19 |
GO:00024603 | Cervix | CC | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 62/2311 | 356/18723 | 3.09e-03 | 2.03e-02 | 62 |
GO:0002443 | Cervix | CC | leukocyte mediated immunity | 73/2311 | 440/18723 | 5.01e-03 | 2.98e-02 | 73 |
GO:0006909 | Cervix | CC | phagocytosis | 53/2311 | 308/18723 | 7.49e-03 | 4.01e-02 | 53 |
GO:00069597 | Cervix | CC | humoral immune response | 54/2311 | 317/18723 | 8.57e-03 | 4.42e-02 | 54 |
GO:00103243 | Cervix | CC | membrane invagination | 28/2311 | 144/18723 | 9.50e-03 | 4.72e-02 | 28 |
GO:000695912 | Cervix | HSIL_HPV | humoral immune response | 39/737 | 317/18723 | 2.88e-10 | 7.02e-08 | 39 |
GO:000269611 | Cervix | HSIL_HPV | positive regulation of leukocyte activation | 44/737 | 409/18723 | 1.58e-09 | 3.04e-07 | 44 |
GO:005086711 | Cervix | HSIL_HPV | positive regulation of cell activation | 44/737 | 420/18723 | 3.59e-09 | 5.76e-07 | 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGHA1 | SNV | Missense_Mutation | rs367887608 | c.508N>A | p.Ala170Thr | p.A170T | P01876 | IG_C_gene | tolerated(0.08) | probably_damaging(0.975) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IGHA1 | SNV | Missense_Mutation | novel | c.947N>A | p.Gly316Asp | p.G316D | P01876 | IG_C_gene | deleterious(0.01) | possibly_damaging(0.594) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IGHA1 | SNV | Missense_Mutation | novel | c.853C>T | p.Pro285Ser | p.P285S | P01876 | IG_C_gene | tolerated(0.08) | benign(0.289) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IGHA1 | SNV | Missense_Mutation | novel | c.577N>A | p.Ala193Thr | p.A193T | P01876 | IG_C_gene | tolerated(0.11) | possibly_damaging(0.787) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IGHA1 | SNV | Missense_Mutation | novel | c.774G>T | p.Lys258Asn | p.K258N | P01876 | IG_C_gene | deleterious(0.01) | probably_damaging(0.931) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IGHA1 | SNV | Missense_Mutation | novel | c.857G>A | p.Ser286Asn | p.S286N | P01876 | IG_C_gene | tolerated(0.11) | possibly_damaging(0.516) | TCGA-AP-A1E4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | zometa | SD |
IGHA1 | SNV | Missense_Mutation | rs750309695 | c.896G>A | p.Arg299His | p.R299H | P01876 | IG_C_gene | deleterious(0) | probably_damaging(0.997) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
IGHA1 | SNV | Missense_Mutation | rs759216050 | c.701N>T | p.Pro234Leu | p.P234L | P01876 | IG_C_gene | deleterious(0) | probably_damaging(0.994) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IGHA1 | SNV | Missense_Mutation | novel | c.1025N>A | p.Ser342Tyr | p.S342Y | P01876 | IG_C_gene | deleterious(0) | probably_damaging(0.988) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
IGHA1 | SNV | Missense_Mutation | rs770875873 | c.991C>T | p.Arg331Cys | p.R331C | P01876 | IG_C_gene | deleterious(0) | probably_damaging(0.994) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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