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Gene: IGFL1 |
Gene summary for IGFL1 |
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Gene information | Species | Human | Gene symbol | IGFL1 | Gene ID | 374918 |
Gene name | IGF like family member 1 | |
Gene Alias | APRG644 | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6UW32 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
374918 | IGFL1 | LZE4T | Human | Esophagus | ESCC | 9.66e-09 | 6.43e-01 | 0.0811 |
374918 | IGFL1 | LZE6T | Human | Esophagus | ESCC | 5.26e-07 | 8.54e-01 | 0.0845 |
374918 | IGFL1 | P11T-E | Human | Esophagus | ESCC | 3.66e-11 | 2.93e+00 | 0.1426 |
374918 | IGFL1 | P17T-E | Human | Esophagus | ESCC | 4.79e-04 | 4.94e-01 | 0.1278 |
374918 | IGFL1 | P21T-E | Human | Esophagus | ESCC | 1.66e-02 | 2.42e-01 | 0.1617 |
374918 | IGFL1 | P28T-E | Human | Esophagus | ESCC | 9.44e-07 | 3.11e-01 | 0.1149 |
374918 | IGFL1 | P32T-E | Human | Esophagus | ESCC | 7.90e-03 | 5.35e-01 | 0.1666 |
374918 | IGFL1 | P83T-E | Human | Esophagus | ESCC | 6.97e-08 | 8.10e-01 | 0.1738 |
374918 | IGFL1 | P89T-E | Human | Esophagus | ESCC | 1.41e-20 | 5.71e+00 | 0.1752 |
374918 | IGFL1 | P91T-E | Human | Esophagus | ESCC | 1.38e-03 | 1.23e+00 | 0.1828 |
374918 | IGFL1 | P107T-E | Human | Esophagus | ESCC | 1.48e-31 | 2.76e+00 | 0.171 |
374918 | IGFL1 | P130T-E | Human | Esophagus | ESCC | 4.12e-11 | 7.66e-01 | 0.1676 |
374918 | IGFL1 | C04 | Human | Oral cavity | OSCC | 4.60e-23 | 2.07e+00 | 0.2633 |
374918 | IGFL1 | C30 | Human | Oral cavity | OSCC | 3.40e-07 | 5.09e-01 | 0.3055 |
374918 | IGFL1 | C06 | Human | Oral cavity | OSCC | 2.06e-09 | 2.77e+00 | 0.2699 |
374918 | IGFL1 | C07 | Human | Oral cavity | OSCC | 9.93e-03 | 3.41e+00 | 0.2491 |
374918 | IGFL1 | C09 | Human | Oral cavity | OSCC | 1.38e-06 | 1.11e+00 | 0.1431 |
374918 | IGFL1 | SYSMH2 | Human | Oral cavity | OSCC | 8.75e-05 | 3.20e-01 | 0.2326 |
374918 | IGFL1 | SYSMH3 | Human | Oral cavity | OSCC | 1.53e-25 | 1.27e+00 | 0.2442 |
374918 | IGFL1 | SYSMH5 | Human | Oral cavity | OSCC | 8.66e-11 | 3.14e-01 | 0.0647 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGFL1 | SNV | Missense_Mutation | novel | c.190G>C | p.Ala64Pro | p.A64P | Q6UW32 | protein_coding | tolerated(0.12) | benign(0.006) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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