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Gene: IFFO1 |
Gene summary for IFFO1 |
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Gene information | Species | Human | Gene symbol | IFFO1 | Gene ID | 25900 |
Gene name | intermediate filament family orphan 1 | |
Gene Alias | HOM-TES-103 | |
Cytomap | 12p13.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q0D2I5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25900 | IFFO1 | HCC1 | Human | Liver | HCC | 7.30e-03 | 3.06e+00 | 0.5336 |
25900 | IFFO1 | S014 | Human | Liver | HCC | 3.26e-11 | 3.63e-01 | 0.2254 |
25900 | IFFO1 | S015 | Human | Liver | HCC | 4.80e-28 | 8.26e-01 | 0.2375 |
25900 | IFFO1 | S016 | Human | Liver | HCC | 6.34e-22 | 4.52e-01 | 0.2243 |
25900 | IFFO1 | S028 | Human | Liver | HCC | 7.45e-08 | 2.79e-01 | 0.2503 |
25900 | IFFO1 | S029 | Human | Liver | HCC | 4.74e-03 | 1.64e-01 | 0.2581 |
25900 | IFFO1 | ATC12 | Human | Thyroid | ATC | 1.42e-26 | 5.38e-01 | 0.34 |
25900 | IFFO1 | ATC13 | Human | Thyroid | ATC | 2.77e-07 | 1.56e-01 | 0.34 |
25900 | IFFO1 | ATC4 | Human | Thyroid | ATC | 5.78e-36 | 6.77e-01 | 0.34 |
25900 | IFFO1 | ATC5 | Human | Thyroid | ATC | 2.60e-07 | 1.69e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00345021 | Liver | HCC | protein localization to chromosome | 55/7958 | 92/18723 | 6.12e-04 | 3.82e-03 | 55 |
GO:00063021 | Liver | HCC | double-strand break repair | 131/7958 | 251/18723 | 1.17e-03 | 6.54e-03 | 131 |
GO:0050000 | Liver | HCC | chromosome localization | 49/7958 | 82/18723 | 1.20e-03 | 6.68e-03 | 49 |
GO:005000013 | Thyroid | ATC | chromosome localization | 49/6293 | 82/18723 | 1.07e-06 | 1.39e-05 | 49 |
GO:003450212 | Thyroid | ATC | protein localization to chromosome | 52/6293 | 92/18723 | 5.21e-06 | 5.61e-05 | 52 |
GO:000630212 | Thyroid | ATC | double-strand break repair | 110/6293 | 251/18723 | 4.48e-04 | 2.65e-03 | 110 |
GO:00063031 | Thyroid | ATC | double-strand break repair via nonhomologous end joining | 33/6293 | 66/18723 | 4.27e-03 | 1.80e-02 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFFO1 | SNV | Missense_Mutation | rs758037048 | c.997N>T | p.Arg333Cys | p.R333C | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IFFO1 | SNV | Missense_Mutation | c.709N>A | p.Glu237Lys | p.E237K | protein_coding | deleterious(0.02) | probably_damaging(0.97) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
IFFO1 | SNV | Missense_Mutation | novel | c.1535N>G | p.Glu512Gly | p.E512G | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
IFFO1 | SNV | Missense_Mutation | c.898N>A | p.Glu300Lys | p.E300K | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
IFFO1 | insertion | Frame_Shift_Ins | rs750779916 | c.1122_1123insG | p.Arg375AlafsTer19 | p.R375Afs*19 | protein_coding | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
IFFO1 | SNV | Missense_Mutation | novel | c.963N>T | p.Glu321Asp | p.E321D | protein_coding | deleterious(0.04) | possibly_damaging(0.681) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IFFO1 | SNV | Missense_Mutation | novel | c.1536G>T | p.Glu512Asp | p.E512D | protein_coding | tolerated(0.2) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
IFFO1 | SNV | Missense_Mutation | rs754217565 | c.247C>T | p.Arg83Trp | p.R83W | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
IFFO1 | SNV | Missense_Mutation | novel | c.641T>C | p.Val214Ala | p.V214A | protein_coding | tolerated(0.08) | benign(0.155) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IFFO1 | SNV | Missense_Mutation | c.1516N>T | p.His506Tyr | p.H506Y | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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