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Gene: ICK |
Gene summary for ICK |
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Gene information | Species | Human | Gene symbol | ICK | Gene ID | 22858 |
Gene name | ciliogenesis associated kinase 1 | |
Gene Alias | ECO | |
Cytomap | 6p12.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A024RD59 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22858 | ICK | LZE2D | Human | Esophagus | HGIN | 8.16e-03 | 4.22e-01 | 0.0642 |
22858 | ICK | LZE2T | Human | Esophagus | ESCC | 4.21e-05 | 1.13e+00 | 0.082 |
22858 | ICK | LZE4T | Human | Esophagus | ESCC | 3.24e-08 | 1.78e-01 | 0.0811 |
22858 | ICK | LZE5T | Human | Esophagus | ESCC | 1.81e-03 | 4.51e-01 | 0.0514 |
22858 | ICK | LZE7T | Human | Esophagus | ESCC | 4.11e-11 | 6.09e-01 | 0.0667 |
22858 | ICK | LZE8T | Human | Esophagus | ESCC | 5.97e-04 | 6.92e-02 | 0.067 |
22858 | ICK | LZE20T | Human | Esophagus | ESCC | 5.26e-05 | 2.78e-01 | 0.0662 |
22858 | ICK | LZE24T | Human | Esophagus | ESCC | 2.22e-16 | 4.97e-01 | 0.0596 |
22858 | ICK | LZE21T | Human | Esophagus | ESCC | 3.36e-07 | 3.86e-01 | 0.0655 |
22858 | ICK | P1T-E | Human | Esophagus | ESCC | 2.28e-07 | 4.15e-01 | 0.0875 |
22858 | ICK | P2T-E | Human | Esophagus | ESCC | 1.43e-15 | 3.08e-01 | 0.1177 |
22858 | ICK | P4T-E | Human | Esophagus | ESCC | 6.71e-31 | 7.56e-01 | 0.1323 |
22858 | ICK | P5T-E | Human | Esophagus | ESCC | 2.98e-03 | 7.61e-02 | 0.1327 |
22858 | ICK | P8T-E | Human | Esophagus | ESCC | 9.58e-14 | 2.75e-01 | 0.0889 |
22858 | ICK | P9T-E | Human | Esophagus | ESCC | 9.95e-20 | 4.63e-01 | 0.1131 |
22858 | ICK | P10T-E | Human | Esophagus | ESCC | 7.51e-16 | 3.66e-01 | 0.116 |
22858 | ICK | P11T-E | Human | Esophagus | ESCC | 2.23e-04 | 1.88e-01 | 0.1426 |
22858 | ICK | P12T-E | Human | Esophagus | ESCC | 8.75e-31 | 8.12e-01 | 0.1122 |
22858 | ICK | P15T-E | Human | Esophagus | ESCC | 1.10e-14 | 2.92e-01 | 0.1149 |
22858 | ICK | P16T-E | Human | Esophagus | ESCC | 8.31e-19 | 4.04e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0042176111 | Esophagus | ESCC | regulation of protein catabolic process | 280/8552 | 391/18723 | 8.65e-26 | 2.39e-23 | 280 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:1903320111 | Esophagus | ESCC | regulation of protein modification by small protein conjugation or removal | 181/8552 | 242/18723 | 1.80e-20 | 2.60e-18 | 181 |
GO:1903362111 | Esophagus | ESCC | regulation of cellular protein catabolic process | 188/8552 | 255/18723 | 5.12e-20 | 6.62e-18 | 188 |
GO:0045862111 | Esophagus | ESCC | positive regulation of proteolysis | 256/8552 | 372/18723 | 7.88e-20 | 9.43e-18 | 256 |
GO:1903050111 | Esophagus | ESCC | regulation of proteolysis involved in cellular protein catabolic process | 163/8552 | 221/18723 | 1.44e-17 | 1.27e-15 | 163 |
GO:0061136111 | Esophagus | ESCC | regulation of proteasomal protein catabolic process | 142/8552 | 187/18723 | 2.40e-17 | 2.00e-15 | 142 |
GO:0045732111 | Esophagus | ESCC | positive regulation of protein catabolic process | 167/8552 | 231/18723 | 1.47e-16 | 1.14e-14 | 167 |
GO:0031396111 | Esophagus | ESCC | regulation of protein ubiquitination | 154/8552 | 210/18723 | 2.70e-16 | 2.04e-14 | 154 |
GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
GO:0032434111 | Esophagus | ESCC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 107/8552 | 134/18723 | 4.06e-16 | 2.93e-14 | 107 |
GO:2000058111 | Esophagus | ESCC | regulation of ubiquitin-dependent protein catabolic process | 125/8552 | 164/18723 | 1.17e-15 | 7.76e-14 | 125 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ICK | SNV | Missense_Mutation | c.839N>C | p.Arg280Pro | p.R280P | Q9UPZ9 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-E9-A1ND-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD | |
ICK | insertion | Nonsense_Mutation | novel | c.976_977insGGTTTTAA | p.Pro326ArgfsTer3 | p.P326Rfs*3 | Q9UPZ9 | protein_coding | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ICK | SNV | Missense_Mutation | c.105N>A | p.Met35Ile | p.M35I | Q9UPZ9 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ICK | SNV | Missense_Mutation | c.1855N>T | p.His619Tyr | p.H619Y | Q9UPZ9 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
ICK | SNV | Missense_Mutation | novel | c.1354G>A | p.Val452Ile | p.V452I | Q9UPZ9 | protein_coding | tolerated(0.33) | benign(0) | TCGA-AA-3856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ICK | SNV | Missense_Mutation | novel | c.1062N>T | p.Glu354Asp | p.E354D | Q9UPZ9 | protein_coding | tolerated(0.6) | benign(0) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ICK | SNV | Missense_Mutation | novel | c.1391N>T | p.Gly464Val | p.G464V | Q9UPZ9 | protein_coding | tolerated(0.22) | benign(0.074) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ICK | SNV | Missense_Mutation | novel | c.1441N>A | p.Leu481Met | p.L481M | Q9UPZ9 | protein_coding | tolerated(0.26) | possibly_damaging(0.498) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ICK | insertion | Frame_Shift_Ins | novel | c.499_500insG | p.Ala167GlyfsTer16 | p.A167Gfs*16 | Q9UPZ9 | protein_coding | TCGA-AA-3860-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | CR | ||
ICK | SNV | Missense_Mutation | rs147049747 | c.1892N>A | p.Arg631Gln | p.R631Q | Q9UPZ9 | protein_coding | deleterious(0.04) | benign(0.096) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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