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Gene: ICA1L |
Gene summary for ICA1L |
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Gene information | Species | Human | Gene symbol | ICA1L | Gene ID | 130026 |
Gene name | islet cell autoantigen 1 like | |
Gene Alias | ALS2CR14 | |
Cytomap | 2q33.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R3W3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
130026 | ICA1L | HTA11_78_2000001011 | Human | Colorectum | AD | 7.08e-04 | 2.28e-01 | -0.1088 |
130026 | ICA1L | HTA11_347_2000001011 | Human | Colorectum | AD | 2.94e-18 | 5.55e-01 | -0.1954 |
130026 | ICA1L | HTA11_696_2000001011 | Human | Colorectum | AD | 5.97e-05 | 3.01e-01 | -0.1464 |
130026 | ICA1L | HTA11_866_2000001011 | Human | Colorectum | AD | 4.28e-02 | 2.09e-01 | -0.1001 |
130026 | ICA1L | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.68e-06 | 2.89e-01 | -0.059 |
130026 | ICA1L | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.05e-15 | 1.21e+00 | 0.0131 |
130026 | ICA1L | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.11e-21 | 6.43e-01 | 0.0338 |
130026 | ICA1L | HTA11_6818_2000001011 | Human | Colorectum | AD | 5.73e-32 | 1.10e+00 | 0.0112 |
130026 | ICA1L | HTA11_11156_2000001011 | Human | Colorectum | AD | 6.62e-05 | 8.20e-01 | 0.0397 |
130026 | ICA1L | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.09e-19 | 7.85e-01 | 0.0588 |
130026 | ICA1L | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.21e-56 | 1.15e+00 | 0.3005 |
130026 | ICA1L | HCC1 | Human | Liver | HCC | 1.53e-12 | 1.75e+00 | 0.5336 |
130026 | ICA1L | HCC2 | Human | Liver | HCC | 1.35e-29 | 3.46e+00 | 0.5341 |
130026 | ICA1L | HCC5 | Human | Liver | HCC | 1.36e-30 | 2.27e+00 | 0.4932 |
130026 | ICA1L | HTA12-15-2 | Human | Pancreas | PDAC | 3.40e-10 | 5.57e-01 | 0.2315 |
130026 | ICA1L | HTA12-23-1 | Human | Pancreas | PDAC | 1.74e-14 | 9.57e-01 | 0.3405 |
130026 | ICA1L | HTA12-25-1 | Human | Pancreas | PDAC | 2.76e-09 | 6.02e-01 | 0.313 |
130026 | ICA1L | HTA12-26-1 | Human | Pancreas | PDAC | 4.22e-23 | 9.00e-01 | 0.3728 |
130026 | ICA1L | HTA12-29-1 | Human | Pancreas | PDAC | 8.86e-50 | 9.15e-01 | 0.3722 |
130026 | ICA1L | HTA12-30-1 | Human | Pancreas | PDAC | 2.27e-04 | 8.81e-01 | 0.3671 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ICA1L | SNV | Missense_Mutation | c.700N>A | p.Phe234Ile | p.F234I | Q8NDH6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ICA1L | SNV | Missense_Mutation | rs745626117 | c.451N>T | p.Arg151Trp | p.R151W | Q8NDH6 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ICA1L | SNV | Missense_Mutation | c.1320N>T | p.Lys440Asn | p.K440N | Q8NDH6 | protein_coding | tolerated(0.1) | benign(0.076) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ICA1L | insertion | In_Frame_Ins | novel | c.373_374insGAG | p.Thr125delinsArgAla | p.T125delinsRA | Q8NDH6 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ICA1L | SNV | Missense_Mutation | rs377572219 | c.289N>T | p.Arg97Trp | p.R97W | Q8NDH6 | protein_coding | deleterious(0.03) | benign(0.056) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ICA1L | SNV | Missense_Mutation | novel | c.1420N>A | p.His474Asn | p.H474N | Q8NDH6 | protein_coding | deleterious(0.04) | possibly_damaging(0.872) | TCGA-AJ-A23N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
ICA1L | SNV | Missense_Mutation | c.1320N>T | p.Lys440Asn | p.K440N | Q8NDH6 | protein_coding | tolerated(0.1) | benign(0.076) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ICA1L | SNV | Missense_Mutation | novel | c.1422C>A | p.His474Gln | p.H474Q | Q8NDH6 | protein_coding | tolerated(0.08) | possibly_damaging(0.831) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ICA1L | SNV | Missense_Mutation | c.173N>A | p.Ser58Tyr | p.S58Y | Q8NDH6 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
ICA1L | SNV | Missense_Mutation | novel | c.213N>T | p.Glu71Asp | p.E71D | Q8NDH6 | protein_coding | tolerated(0.06) | probably_damaging(0.998) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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