![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: IARS2 |
Gene summary for IARS2 |
![]() |
Gene information | Species | Human | Gene symbol | IARS2 | Gene ID | 55699 |
Gene name | isoleucyl-tRNA synthetase 2, mitochondrial | |
Gene Alias | CAGSSS | |
Cytomap | 1q41 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q9NSE4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55699 | IARS2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.86e-06 | 3.70e-01 | -0.1954 |
55699 | IARS2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.75e-03 | 4.05e-01 | 0.281 |
55699 | IARS2 | A015-C-203 | Human | Colorectum | FAP | 2.10e-09 | -1.87e-01 | -0.1294 |
55699 | IARS2 | A001-C-108 | Human | Colorectum | FAP | 4.04e-03 | -8.75e-02 | -0.0272 |
55699 | IARS2 | A002-C-205 | Human | Colorectum | FAP | 6.82e-03 | -1.23e-01 | -0.1236 |
55699 | IARS2 | A015-C-006 | Human | Colorectum | FAP | 5.60e-03 | -2.10e-01 | -0.0994 |
55699 | IARS2 | A015-C-106 | Human | Colorectum | FAP | 1.48e-03 | -1.11e-01 | -0.0511 |
55699 | IARS2 | A002-C-114 | Human | Colorectum | FAP | 1.35e-02 | -1.51e-01 | -0.1561 |
55699 | IARS2 | A015-C-104 | Human | Colorectum | FAP | 5.98e-08 | -1.42e-01 | -0.1899 |
55699 | IARS2 | A001-C-014 | Human | Colorectum | FAP | 6.49e-05 | -1.07e-01 | 0.0135 |
55699 | IARS2 | A002-C-016 | Human | Colorectum | FAP | 8.71e-03 | -8.71e-02 | 0.0521 |
55699 | IARS2 | A001-C-203 | Human | Colorectum | FAP | 5.30e-03 | -8.34e-02 | -0.0481 |
55699 | IARS2 | A002-C-116 | Human | Colorectum | FAP | 9.73e-09 | -1.45e-01 | -0.0452 |
55699 | IARS2 | A018-E-020 | Human | Colorectum | FAP | 1.08e-03 | -1.71e-01 | -0.2034 |
55699 | IARS2 | F034 | Human | Colorectum | FAP | 6.15e-05 | -1.57e-01 | -0.0665 |
55699 | IARS2 | CRC-3-11773 | Human | Colorectum | CRC | 4.71e-02 | -9.99e-02 | 0.2564 |
55699 | IARS2 | LZE2T | Human | Esophagus | ESCC | 4.43e-13 | 1.64e+00 | 0.082 |
55699 | IARS2 | LZE4T | Human | Esophagus | ESCC | 3.85e-12 | 5.37e-01 | 0.0811 |
55699 | IARS2 | LZE7T | Human | Esophagus | ESCC | 7.38e-13 | 8.10e-01 | 0.0667 |
55699 | IARS2 | LZE20T | Human | Esophagus | ESCC | 8.45e-03 | 1.54e-01 | 0.0662 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006418 | Colorectum | AD | tRNA aminoacylation for protein translation | 19/3918 | 41/18723 | 2.37e-04 | 3.03e-03 | 19 |
GO:0043039 | Colorectum | AD | tRNA aminoacylation | 19/3918 | 44/18723 | 7.13e-04 | 7.21e-03 | 19 |
GO:0043038 | Colorectum | AD | amino acid activation | 19/3918 | 45/18723 | 9.94e-04 | 9.28e-03 | 19 |
GO:0006520 | Colorectum | AD | cellular amino acid metabolic process | 81/3918 | 284/18723 | 1.37e-03 | 1.19e-02 | 81 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:003254314 | Esophagus | ESCC | mitochondrial translation | 68/8552 | 76/18723 | 1.02e-15 | 6.86e-14 | 68 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
GO:0032543 | Liver | Cirrhotic | mitochondrial translation | 40/4634 | 76/18723 | 1.61e-07 | 4.29e-06 | 40 |
GO:0140053 | Liver | Cirrhotic | mitochondrial gene expression | 49/4634 | 108/18723 | 2.35e-06 | 4.31e-05 | 49 |
GO:000652011 | Liver | Cirrhotic | cellular amino acid metabolic process | 103/4634 | 284/18723 | 8.88e-06 | 1.30e-04 | 103 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:01400531 | Liver | HCC | mitochondrial gene expression | 82/7958 | 108/18723 | 1.49e-12 | 7.20e-11 | 82 |
GO:00325431 | Liver | HCC | mitochondrial translation | 62/7958 | 76/18723 | 2.95e-12 | 1.34e-10 | 62 |
GO:00065202 | Liver | HCC | cellular amino acid metabolic process | 167/7958 | 284/18723 | 1.91e-08 | 4.56e-07 | 167 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:01400533 | Oral cavity | OSCC | mitochondrial gene expression | 78/7305 | 108/18723 | 2.37e-12 | 9.86e-11 | 78 |
GO:00325434 | Oral cavity | OSCC | mitochondrial translation | 59/7305 | 76/18723 | 7.21e-12 | 2.70e-10 | 59 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IARS2 | SNV | Missense_Mutation | c.1582N>C | p.Trp528Arg | p.W528R | Q9NSE4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
IARS2 | SNV | Missense_Mutation | c.1708N>T | p.Pro570Ser | p.P570S | Q9NSE4 | protein_coding | tolerated(0.75) | benign(0.005) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
IARS2 | SNV | Missense_Mutation | c.941N>T | p.Pro314Leu | p.P314L | Q9NSE4 | protein_coding | deleterious(0.02) | benign(0.134) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IARS2 | SNV | Missense_Mutation | c.2191C>T | p.Arg731Cys | p.R731C | Q9NSE4 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IARS2 | SNV | Missense_Mutation | novel | c.1663N>C | p.Lys555Gln | p.K555Q | Q9NSE4 | protein_coding | tolerated(0.31) | benign(0.007) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IARS2 | SNV | Missense_Mutation | rs368937943 | c.625A>G | p.Asn209Asp | p.N209D | Q9NSE4 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AA-A02J-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
IARS2 | SNV | Missense_Mutation | c.2035N>A | p.Val679Ile | p.V679I | Q9NSE4 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
IARS2 | SNV | Missense_Mutation | c.413G>A | p.Arg138Gln | p.R138Q | Q9NSE4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
IARS2 | SNV | Missense_Mutation | rs769112693 | c.808T>C | p.Tyr270His | p.Y270H | Q9NSE4 | protein_coding | deleterious(0.04) | probably_damaging(0.995) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IARS2 | SNV | Missense_Mutation | rs779950037 | c.2984C>T | p.Ala995Val | p.A995V | Q9NSE4 | protein_coding | tolerated(0.1) | benign(0.13) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |