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Gene: HTRA3 |
Gene summary for HTRA3 |
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Gene information | Species | Human | Gene symbol | HTRA3 | Gene ID | 94031 |
Gene name | HtrA serine peptidase 3 | |
Gene Alias | Prsp | |
Cytomap | 4p16.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P83110 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
94031 | HTRA3 | C04 | Human | Oral cavity | OSCC | 1.13e-04 | 2.97e-01 | 0.2633 |
94031 | HTRA3 | C30 | Human | Oral cavity | OSCC | 1.81e-19 | 9.81e-01 | 0.3055 |
94031 | HTRA3 | C06 | Human | Oral cavity | OSCC | 1.57e-11 | 1.66e+00 | 0.2699 |
94031 | HTRA3 | NEOLP-1 | Human | Oral cavity | NEOLP | 1.14e-02 | 1.48e-01 | -0.0194 |
94031 | HTRA3 | male-WTA | Human | Thyroid | PTC | 2.64e-07 | 1.00e-01 | 0.1037 |
94031 | HTRA3 | ATC12 | Human | Thyroid | ATC | 5.65e-43 | 1.14e+00 | 0.34 |
94031 | HTRA3 | ATC13 | Human | Thyroid | ATC | 3.80e-27 | 7.62e-01 | 0.34 |
94031 | HTRA3 | ATC4 | Human | Thyroid | ATC | 3.24e-52 | 1.34e+00 | 0.34 |
94031 | HTRA3 | ATC5 | Human | Thyroid | ATC | 3.60e-33 | 8.38e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00715598 | Oral cavity | OSCC | response to transforming growth factor beta | 140/7305 | 256/18723 | 2.34e-07 | 3.70e-06 | 140 |
GO:00715608 | Oral cavity | OSCC | cellular response to transforming growth factor beta stimulus | 137/7305 | 250/18723 | 2.68e-07 | 4.15e-06 | 137 |
GO:00071798 | Oral cavity | OSCC | transforming growth factor beta receptor signaling pathway | 109/7305 | 198/18723 | 3.21e-06 | 3.86e-05 | 109 |
GO:00170155 | Oral cavity | OSCC | regulation of transforming growth factor beta receptor signaling pathway | 71/7305 | 128/18723 | 1.14e-04 | 8.34e-04 | 71 |
GO:19038446 | Oral cavity | OSCC | regulation of cellular response to transforming growth factor beta stimulus | 72/7305 | 131/18723 | 1.51e-04 | 1.06e-03 | 72 |
GO:00071789 | Oral cavity | OSCC | transmembrane receptor protein serine/threonine kinase signaling pathway | 165/7305 | 355/18723 | 2.31e-03 | 1.02e-02 | 165 |
GO:007155924 | Oral cavity | NEOLP | response to transforming growth factor beta | 59/2005 | 256/18723 | 8.84e-09 | 4.49e-07 | 59 |
GO:007156024 | Oral cavity | NEOLP | cellular response to transforming growth factor beta stimulus | 58/2005 | 250/18723 | 9.13e-09 | 4.56e-07 | 58 |
GO:000717923 | Oral cavity | NEOLP | transforming growth factor beta receptor signaling pathway | 48/2005 | 198/18723 | 4.01e-08 | 1.66e-06 | 48 |
GO:000717822 | Oral cavity | NEOLP | transmembrane receptor protein serine/threonine kinase signaling pathway | 70/2005 | 355/18723 | 3.04e-07 | 9.62e-06 | 70 |
GO:001701521 | Oral cavity | NEOLP | regulation of transforming growth factor beta receptor signaling pathway | 33/2005 | 128/18723 | 1.18e-06 | 3.08e-05 | 33 |
GO:190384421 | Oral cavity | NEOLP | regulation of cellular response to transforming growth factor beta stimulus | 33/2005 | 131/18723 | 2.05e-06 | 4.86e-05 | 33 |
GO:003051211 | Oral cavity | NEOLP | negative regulation of transforming growth factor beta receptor signaling pathway | 24/2005 | 81/18723 | 2.40e-06 | 5.53e-05 | 24 |
GO:00901011 | Oral cavity | NEOLP | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 32/2005 | 131/18723 | 5.88e-06 | 1.19e-04 | 32 |
GO:009028711 | Oral cavity | NEOLP | regulation of cellular response to growth factor stimulus | 56/2005 | 304/18723 | 3.55e-05 | 5.20e-04 | 56 |
GO:009009213 | Oral cavity | NEOLP | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 49/2005 | 256/18723 | 3.90e-05 | 5.62e-04 | 49 |
GO:00305101 | Oral cavity | NEOLP | regulation of BMP signaling pathway | 20/2005 | 96/18723 | 2.60e-03 | 1.63e-02 | 20 |
GO:007177212 | Oral cavity | NEOLP | response to BMP | 29/2005 | 165/18723 | 5.04e-03 | 2.73e-02 | 29 |
GO:007177312 | Oral cavity | NEOLP | cellular response to BMP stimulus | 29/2005 | 165/18723 | 5.04e-03 | 2.73e-02 | 29 |
GO:003050912 | Oral cavity | NEOLP | BMP signaling pathway | 27/2005 | 152/18723 | 5.75e-03 | 3.04e-02 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HTRA3 | SNV | Missense_Mutation | rs746960044 | c.410N>A | p.Arg137His | p.R137H | P83110 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-DM-A28K-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HTRA3 | SNV | Missense_Mutation | c.1094C>T | p.Thr365Ile | p.T365I | P83110 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-G4-6303-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD | |
HTRA3 | SNV | Missense_Mutation | c.836G>A | p.Arg279Gln | p.R279Q | P83110 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
HTRA3 | SNV | Missense_Mutation | c.1225N>A | p.Val409Ile | p.V409I | P83110 | protein_coding | tolerated(0.59) | benign(0.105) | TCGA-QG-A5Z1-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | ||
HTRA3 | SNV | Missense_Mutation | c.522N>A | p.Ser174Arg | p.S174R | P83110 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-EI-6885-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatinum+5-fu | PD | |
HTRA3 | SNV | Missense_Mutation | novel | c.1297C>A | p.Leu433Ile | p.L433I | P83110 | protein_coding | tolerated(0.29) | possibly_damaging(0.488) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HTRA3 | SNV | Missense_Mutation | novel | c.1337N>T | p.Ser446Ile | p.S446I | P83110 | protein_coding | deleterious(0.01) | probably_damaging(0.974) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HTRA3 | SNV | Missense_Mutation | rs377511028 | c.1015N>T | p.Arg339Trp | p.R339W | P83110 | protein_coding | deleterious(0) | possibly_damaging(0.462) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
HTRA3 | SNV | Missense_Mutation | novel | c.798N>T | p.Gln266His | p.Q266H | P83110 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HTRA3 | SNV | Missense_Mutation | novel | c.569N>T | p.Ala190Val | p.A190V | P83110 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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