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Gene: HSPA12A |
Gene summary for HSPA12A |
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Gene information | Species | Human | Gene symbol | HSPA12A | Gene ID | 259217 |
Gene name | heat shock protein family A (Hsp70) member 12A | |
Gene Alias | HSPA12A | |
Cytomap | 10q25.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A1B0GTF3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
259217 | HSPA12A | HCC1_Meng | Human | Liver | HCC | 8.94e-05 | -1.31e-02 | 0.0246 |
259217 | HSPA12A | Pt13.b | Human | Liver | HCC | 2.32e-02 | 1.00e-01 | 0.0251 |
259217 | HSPA12A | S014 | Human | Liver | HCC | 1.62e-24 | 7.87e-01 | 0.2254 |
259217 | HSPA12A | S015 | Human | Liver | HCC | 8.31e-25 | 8.92e-01 | 0.2375 |
259217 | HSPA12A | S016 | Human | Liver | HCC | 2.06e-34 | 9.16e-01 | 0.2243 |
259217 | HSPA12A | S028 | Human | Liver | HCC | 1.12e-07 | 3.29e-01 | 0.2503 |
259217 | HSPA12A | S029 | Human | Liver | HCC | 1.93e-06 | 3.25e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSPA12A | insertion | Frame_Shift_Ins | novel | c.1211_1212insTTTTGTGTCTCAGCTT | p.Glu404AspfsTer18 | p.E404Dfs*18 | protein_coding | TCGA-BH-A0DP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |||
HSPA12A | SNV | Missense_Mutation | rs781929997 | c.853N>A | p.Gly285Ser | p.G285S | protein_coding | tolerated(0.88) | benign(0) | TCGA-HM-A6W2-06 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
HSPA12A | SNV | Missense_Mutation | rs782065581 | c.127C>T | p.Arg43Trp | p.R43W | protein_coding | deleterious_low_confidence(0.04) | probably_damaging(0.942) | TCGA-MA-AA43-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
HSPA12A | SNV | Missense_Mutation | rs782338580 | c.911N>A | p.Arg304Gln | p.R304Q | protein_coding | tolerated(0.09) | probably_damaging(0.991) | TCGA-A6-2679-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HSPA12A | SNV | Missense_Mutation | c.1354N>C | p.Trp452Arg | p.W452R | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
HSPA12A | SNV | Missense_Mutation | rs782338580 | c.911N>A | p.Arg304Gln | p.R304Q | protein_coding | tolerated(0.09) | probably_damaging(0.991) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
HSPA12A | SNV | Missense_Mutation | c.521N>T | p.Ala174Val | p.A174V | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
HSPA12A | SNV | Missense_Mutation | c.552N>C | p.Glu184Asp | p.E184D | protein_coding | tolerated(0.59) | benign(0.003) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
HSPA12A | SNV | Missense_Mutation | rs781852527 | c.1652N>T | p.Pro551Leu | p.P551L | protein_coding | deleterious(0.05) | probably_damaging(1) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
HSPA12A | SNV | Missense_Mutation | rs782115853 | c.1681N>T | p.Arg561Cys | p.R561C | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AD-6899-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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