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Gene: HSD17B8 |
Gene summary for HSD17B8 |
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Gene information | Species | Human | Gene symbol | HSD17B8 | Gene ID | 7923 |
Gene name | hydroxysteroid 17-beta dehydrogenase 8 | |
Gene Alias | D6S2245E | |
Cytomap | 6p21.32 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | A0A1U9X7U3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7923 | HSD17B8 | LZE4T | Human | Esophagus | ESCC | 3.03e-10 | 3.02e-01 | 0.0811 |
7923 | HSD17B8 | LZE7T | Human | Esophagus | ESCC | 4.82e-02 | 1.26e-01 | 0.0667 |
7923 | HSD17B8 | LZE20T | Human | Esophagus | ESCC | 5.22e-03 | 2.05e-01 | 0.0662 |
7923 | HSD17B8 | LZE22T | Human | Esophagus | ESCC | 2.99e-03 | 2.75e-01 | 0.068 |
7923 | HSD17B8 | LZE24T | Human | Esophagus | ESCC | 1.62e-22 | 6.40e-01 | 0.0596 |
7923 | HSD17B8 | LZE21T | Human | Esophagus | ESCC | 8.29e-04 | 2.78e-01 | 0.0655 |
7923 | HSD17B8 | P1T-E | Human | Esophagus | ESCC | 2.13e-08 | 3.76e-01 | 0.0875 |
7923 | HSD17B8 | P2T-E | Human | Esophagus | ESCC | 4.75e-25 | 6.77e-01 | 0.1177 |
7923 | HSD17B8 | P4T-E | Human | Esophagus | ESCC | 3.30e-36 | 9.05e-01 | 0.1323 |
7923 | HSD17B8 | P5T-E | Human | Esophagus | ESCC | 1.71e-30 | 6.53e-01 | 0.1327 |
7923 | HSD17B8 | P8T-E | Human | Esophagus | ESCC | 3.21e-15 | 3.79e-01 | 0.0889 |
7923 | HSD17B8 | P9T-E | Human | Esophagus | ESCC | 2.05e-11 | 3.65e-01 | 0.1131 |
7923 | HSD17B8 | P10T-E | Human | Esophagus | ESCC | 1.73e-24 | 4.19e-01 | 0.116 |
7923 | HSD17B8 | P11T-E | Human | Esophagus | ESCC | 2.26e-03 | 2.89e-01 | 0.1426 |
7923 | HSD17B8 | P12T-E | Human | Esophagus | ESCC | 7.17e-29 | 6.47e-01 | 0.1122 |
7923 | HSD17B8 | P15T-E | Human | Esophagus | ESCC | 2.75e-13 | 2.94e-01 | 0.1149 |
7923 | HSD17B8 | P16T-E | Human | Esophagus | ESCC | 2.17e-22 | 4.52e-01 | 0.1153 |
7923 | HSD17B8 | P17T-E | Human | Esophagus | ESCC | 5.32e-12 | 4.98e-01 | 0.1278 |
7923 | HSD17B8 | P20T-E | Human | Esophagus | ESCC | 7.68e-11 | 2.04e-01 | 0.1124 |
7923 | HSD17B8 | P21T-E | Human | Esophagus | ESCC | 1.43e-12 | 2.45e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00066318 | Esophagus | ESCC | fatty acid metabolic process | 217/8552 | 390/18723 | 4.21e-05 | 3.39e-04 | 217 |
GO:00463948 | Esophagus | ESCC | carboxylic acid biosynthetic process | 175/8552 | 314/18723 | 1.98e-04 | 1.26e-03 | 175 |
GO:00160538 | Esophagus | ESCC | organic acid biosynthetic process | 175/8552 | 316/18723 | 3.04e-04 | 1.82e-03 | 175 |
GO:00512623 | Esophagus | ESCC | protein tetramerization | 54/8552 | 87/18723 | 1.50e-03 | 7.06e-03 | 54 |
GO:00066946 | Esophagus | ESCC | steroid biosynthetic process | 98/8552 | 173/18723 | 2.34e-03 | 1.03e-02 | 98 |
GO:00512592 | Esophagus | ESCC | protein complex oligomerization | 130/8552 | 238/18723 | 3.29e-03 | 1.36e-02 | 130 |
GO:000820211 | Liver | Cirrhotic | steroid metabolic process | 143/4634 | 319/18723 | 2.79e-15 | 3.18e-13 | 143 |
GO:000663112 | Liver | Cirrhotic | fatty acid metabolic process | 165/4634 | 390/18723 | 1.29e-14 | 1.26e-12 | 165 |
GO:001605312 | Liver | Cirrhotic | organic acid biosynthetic process | 139/4634 | 316/18723 | 4.28e-14 | 3.83e-12 | 139 |
GO:004639412 | Liver | Cirrhotic | carboxylic acid biosynthetic process | 137/4634 | 314/18723 | 1.40e-13 | 1.14e-11 | 137 |
GO:007233011 | Liver | Cirrhotic | monocarboxylic acid biosynthetic process | 93/4634 | 214/18723 | 1.43e-09 | 6.16e-08 | 93 |
GO:00066941 | Liver | Cirrhotic | steroid biosynthetic process | 77/4634 | 173/18723 | 1.02e-08 | 3.91e-07 | 77 |
GO:000663311 | Liver | Cirrhotic | fatty acid biosynthetic process | 70/4634 | 163/18723 | 2.57e-07 | 6.41e-06 | 70 |
GO:00082101 | Liver | Cirrhotic | estrogen metabolic process | 18/4634 | 38/18723 | 2.05e-03 | 1.27e-02 | 18 |
GO:004244511 | Liver | Cirrhotic | hormone metabolic process | 73/4634 | 218/18723 | 2.22e-03 | 1.36e-02 | 73 |
GO:0008209 | Liver | Cirrhotic | androgen metabolic process | 15/4634 | 30/18723 | 2.45e-03 | 1.47e-02 | 15 |
GO:001605321 | Liver | HCC | organic acid biosynthetic process | 200/7958 | 316/18723 | 5.24e-14 | 3.22e-12 | 200 |
GO:000663122 | Liver | HCC | fatty acid metabolic process | 238/7958 | 390/18723 | 8.24e-14 | 4.84e-12 | 238 |
GO:004639421 | Liver | HCC | carboxylic acid biosynthetic process | 198/7958 | 314/18723 | 1.19e-13 | 6.78e-12 | 198 |
GO:00082022 | Liver | HCC | steroid metabolic process | 188/7958 | 319/18723 | 1.96e-09 | 5.63e-08 | 188 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012129 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa0121214 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa012122 | Liver | Cirrhotic | Fatty acid metabolism | 32/2530 | 57/8465 | 3.12e-05 | 2.47e-04 | 1.52e-04 | 32 |
hsa012123 | Liver | Cirrhotic | Fatty acid metabolism | 32/2530 | 57/8465 | 3.12e-05 | 2.47e-04 | 1.52e-04 | 32 |
hsa012124 | Liver | HCC | Fatty acid metabolism | 45/4020 | 57/8465 | 1.05e-06 | 1.10e-05 | 6.09e-06 | 45 |
hsa00061 | Liver | HCC | Fatty acid biosynthesis | 14/4020 | 18/8465 | 8.82e-03 | 2.36e-02 | 1.32e-02 | 14 |
hsa012125 | Liver | HCC | Fatty acid metabolism | 45/4020 | 57/8465 | 1.05e-06 | 1.10e-05 | 6.09e-06 | 45 |
hsa000611 | Liver | HCC | Fatty acid biosynthesis | 14/4020 | 18/8465 | 8.82e-03 | 2.36e-02 | 1.32e-02 | 14 |
hsa012128 | Oral cavity | OSCC | Fatty acid metabolism | 35/3704 | 57/8465 | 5.37e-03 | 1.29e-02 | 6.55e-03 | 35 |
hsa0121213 | Oral cavity | OSCC | Fatty acid metabolism | 35/3704 | 57/8465 | 5.37e-03 | 1.29e-02 | 6.55e-03 | 35 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSD17B8 | SNV | Missense_Mutation | c.469N>G | p.Ile157Val | p.I157V | Q92506 | protein_coding | deleterious(0.04) | probably_damaging(0.995) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HSD17B8 | SNV | Missense_Mutation | c.281N>A | p.Ser94Tyr | p.S94Y | Q92506 | protein_coding | deleterious(0.02) | benign(0.243) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
HSD17B8 | SNV | Missense_Mutation | novel | c.780N>A | p.Phe260Leu | p.F260L | Q92506 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-QF-A5YS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
HSD17B8 | SNV | Missense_Mutation | novel | c.240G>T | p.Arg80Ser | p.R80S | Q92506 | protein_coding | tolerated(0.58) | benign(0) | TCGA-DD-AAC9-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HSD17B8 | SNV | Missense_Mutation | c.472N>C | p.Val158Leu | p.V158L | Q92506 | protein_coding | deleterious(0.01) | benign(0.208) | TCGA-BA-A4II-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
HSD17B8 | SNV | Missense_Mutation | novel | c.596C>A | p.Pro199Gln | p.P199Q | Q92506 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-CR-7389-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | CR |
HSD17B8 | SNV | Missense_Mutation | novel | c.755N>T | p.Ser252Leu | p.S252L | Q92506 | protein_coding | deleterious(0.01) | possibly_damaging(0.538) | TCGA-CV-A6K2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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