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Gene: HS3ST3A1 |
Gene summary for HS3ST3A1 |
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Gene information | Species | Human | Gene symbol | HS3ST3A1 | Gene ID | 9955 |
Gene name | heparan sulfate-glucosamine 3-sulfotransferase 3A1 | |
Gene Alias | 3-OST-3A | |
Cytomap | 17p12 | |
Gene Type | protein-coding | GO ID | GO:0006022 | UniProtAcc | Q9Y663 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9955 | HS3ST3A1 | CCI_1 | Human | Cervix | CC | 9.52e-06 | 3.49e-01 | 0.528 |
9955 | HS3ST3A1 | CCI_2 | Human | Cervix | CC | 2.02e-20 | 1.24e+00 | 0.5249 |
9955 | HS3ST3A1 | P9T-E | Human | Esophagus | ESCC | 7.64e-18 | 5.12e-01 | 0.1131 |
9955 | HS3ST3A1 | P21T-E | Human | Esophagus | ESCC | 2.37e-12 | 2.05e-01 | 0.1617 |
9955 | HS3ST3A1 | P24T-E | Human | Esophagus | ESCC | 1.67e-15 | 6.93e-01 | 0.1287 |
9955 | HS3ST3A1 | P32T-E | Human | Esophagus | ESCC | 5.19e-03 | 8.62e-02 | 0.1666 |
9955 | HS3ST3A1 | P36T-E | Human | Esophagus | ESCC | 1.64e-09 | 4.47e-01 | 0.1187 |
9955 | HS3ST3A1 | P37T-E | Human | Esophagus | ESCC | 6.46e-10 | 2.52e-01 | 0.1371 |
9955 | HS3ST3A1 | P39T-E | Human | Esophagus | ESCC | 4.12e-05 | 2.21e-01 | 0.0894 |
9955 | HS3ST3A1 | P62T-E | Human | Esophagus | ESCC | 3.90e-12 | 3.96e-01 | 0.1302 |
9955 | HS3ST3A1 | P76T-E | Human | Esophagus | ESCC | 4.66e-03 | 1.17e-01 | 0.1207 |
9955 | HS3ST3A1 | P107T-E | Human | Esophagus | ESCC | 2.26e-07 | 3.02e-01 | 0.171 |
9955 | HS3ST3A1 | P128T-E | Human | Esophagus | ESCC | 4.39e-02 | 3.13e-01 | 0.1241 |
9955 | HS3ST3A1 | P130T-E | Human | Esophagus | ESCC | 5.48e-25 | 6.19e-01 | 0.1676 |
9955 | HS3ST3A1 | ATC09 | Human | Thyroid | ATC | 3.46e-09 | 4.03e-01 | 0.2871 |
9955 | HS3ST3A1 | ATC11 | Human | Thyroid | ATC | 1.60e-07 | 4.72e-01 | 0.3386 |
9955 | HS3ST3A1 | ATC12 | Human | Thyroid | ATC | 3.28e-16 | 3.47e-01 | 0.34 |
9955 | HS3ST3A1 | ATC1 | Human | Thyroid | ATC | 1.26e-09 | 4.51e-01 | 0.2878 |
9955 | HS3ST3A1 | ATC2 | Human | Thyroid | ATC | 8.57e-18 | 1.13e+00 | 0.34 |
9955 | HS3ST3A1 | ATC3 | Human | Thyroid | ATC | 1.38e-16 | 6.49e-01 | 0.338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006024 | Esophagus | ESCC | glycosaminoglycan biosynthetic process | 45/8552 | 75/18723 | 8.75e-03 | 3.08e-02 | 45 |
GO:0006023 | Esophagus | ESCC | aminoglycan biosynthetic process | 47/8552 | 79/18723 | 9.29e-03 | 3.23e-02 | 47 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HS3ST3A1 | SNV | Missense_Mutation | c.842N>T | p.Thr281Met | p.T281M | Q9Y663 | protein_coding | deleterious(0.03) | benign(0.156) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
HS3ST3A1 | SNV | Missense_Mutation | rs776220482 | c.767C>T | p.Thr256Met | p.T256M | Q9Y663 | protein_coding | deleterious(0.01) | benign(0.372) | TCGA-CK-6747-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HS3ST3A1 | SNV | Missense_Mutation | c.133C>T | p.Arg45Cys | p.R45C | Q9Y663 | protein_coding | tolerated_low_confidence(0.22) | benign(0.165) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
HS3ST3A1 | SNV | Missense_Mutation | c.1130G>A | p.Arg377His | p.R377H | Q9Y663 | protein_coding | deleterious(0.01) | benign(0.215) | TCGA-F4-6854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HS3ST3A1 | SNV | Missense_Mutation | novel | c.801N>T | p.Glu267Asp | p.E267D | Q9Y663 | protein_coding | deleterious(0.02) | benign(0.086) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HS3ST3A1 | SNV | Missense_Mutation | c.667N>T | p.Arg223Trp | p.R223W | Q9Y663 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-DC-5337-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HS3ST3A1 | insertion | Frame_Shift_Ins | novel | c.1111_1112insTGGTTATCCAT | p.Thr371MetfsTer31 | p.T371Mfs*31 | Q9Y663 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HS3ST3A1 | SNV | Missense_Mutation | rs750522076 | c.679N>A | p.Ala227Thr | p.A227T | Q9Y663 | protein_coding | tolerated(0.13) | benign(0.06) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HS3ST3A1 | SNV | Missense_Mutation | novel | c.943N>T | p.Leu315Phe | p.L315F | Q9Y663 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HS3ST3A1 | SNV | Missense_Mutation | novel | c.940N>T | p.Arg314Trp | p.R314W | Q9Y663 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A5-A0G5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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