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Gene: HOXC13 |
Gene summary for HOXC13 |
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Gene information | Species | Human | Gene symbol | HOXC13 | Gene ID | 3229 |
Gene name | homeobox C13 | |
Gene Alias | ECTD9 | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P31276 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3229 | HOXC13 | C04 | Human | Oral cavity | OSCC | 6.21e-03 | 2.20e-01 | 0.2633 |
3229 | HOXC13 | C21 | Human | Oral cavity | OSCC | 2.49e-03 | 1.57e-01 | 0.2678 |
3229 | HOXC13 | C30 | Human | Oral cavity | OSCC | 3.74e-18 | 5.85e-01 | 0.3055 |
3229 | HOXC13 | C51 | Human | Oral cavity | OSCC | 4.98e-04 | 2.05e-01 | 0.2674 |
3229 | HOXC13 | C06 | Human | Oral cavity | OSCC | 1.28e-06 | 5.41e-01 | 0.2699 |
3229 | HOXC13 | SYSMH2 | Human | Oral cavity | OSCC | 1.66e-02 | 1.12e-01 | 0.2326 |
3229 | HOXC13 | SYSMH3 | Human | Oral cavity | OSCC | 3.71e-12 | 2.57e-01 | 0.2442 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
HOXC13 | MDSCs | Esophagus | ADJ | ATG101,MIEN1,ZFP37, etc. | 7.32e-02 | ![]() |
HOXC13 | MDSCs | Esophagus | ESCC | ATG101,MIEN1,ZFP37, etc. | 2.25e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HOXC13 | SNV | Missense_Mutation | novel | c.532N>G | p.Phe178Val | p.F178V | P31276 | protein_coding | deleterious(0) | benign(0.101) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HOXC13 | SNV | Missense_Mutation | rs764018957 | c.775C>T | p.Arg259Cys | p.R259C | P31276 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HOXC13 | SNV | Missense_Mutation | novel | c.838N>A | p.Ala280Thr | p.A280T | P31276 | protein_coding | tolerated(0.08) | possibly_damaging(0.545) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HOXC13 | SNV | Missense_Mutation | novel | c.395N>A | p.Cys132Tyr | p.C132Y | P31276 | protein_coding | tolerated(0.05) | probably_damaging(0.998) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HOXC13 | SNV | Missense_Mutation | novel | c.742N>A | p.Val248Ile | p.V248I | P31276 | protein_coding | tolerated(0.07) | benign(0.168) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
HOXC13 | SNV | Missense_Mutation | novel | c.601C>T | p.Pro201Ser | p.P201S | P31276 | protein_coding | tolerated(0.39) | benign(0.007) | TCGA-E6-A2P8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
HOXC13 | SNV | Missense_Mutation | novel | c.864G>T | p.Glu288Asp | p.E288D | P31276 | protein_coding | tolerated(1) | benign(0.02) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HOXC13 | SNV | Missense_Mutation | rs781495718 | c.466N>A | p.Pro156Thr | p.P156T | P31276 | protein_coding | tolerated(1) | benign(0.003) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
HOXC13 | SNV | Missense_Mutation | c.577G>T | p.Val193Leu | p.V193L | P31276 | protein_coding | deleterious(0) | benign(0.348) | TCGA-05-4410-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HOXC13 | SNV | Missense_Mutation | c.874N>G | p.Arg292Gly | p.R292G | P31276 | protein_coding | deleterious(0) | possibly_damaging(0.841) | TCGA-64-5778-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Targeted Molecular therapy | tarceva | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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