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Gene: HOXB9 |
Gene summary for HOXB9 |
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Gene information | Species | Human | Gene symbol | HOXB9 | Gene ID | 3219 |
Gene name | homeobox B9 | |
Gene Alias | HOX-2.5 | |
Cytomap | 17q21.32 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | B3KPJ1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3219 | HOXB9 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.62e-52 | 7.90e-01 | 0.0155 |
3219 | HOXB9 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.30e-29 | 6.60e-01 | -0.1808 |
3219 | HOXB9 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.84e-10 | 6.30e-01 | 0.0216 |
3219 | HOXB9 | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.68e-63 | 1.68e+00 | -0.0811 |
3219 | HOXB9 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.61e-59 | 1.34e+00 | -0.1088 |
3219 | HOXB9 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.88e-77 | 1.39e+00 | -0.1954 |
3219 | HOXB9 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.35e-12 | 6.90e-01 | -0.2602 |
3219 | HOXB9 | HTA11_2112_2000001011 | Human | Colorectum | SER | 8.76e-08 | 7.96e-01 | -0.2196 |
3219 | HOXB9 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.73e-31 | 9.81e-01 | -0.1207 |
3219 | HOXB9 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.22e-35 | 1.06e+00 | -0.1526 |
3219 | HOXB9 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.40e-57 | 1.03e+00 | -0.1464 |
3219 | HOXB9 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.11e-46 | 8.30e-01 | -0.1001 |
3219 | HOXB9 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.00e-59 | 1.56e+00 | -0.059 |
3219 | HOXB9 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.51e-04 | 3.10e-01 | -0.1706 |
3219 | HOXB9 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.61e-16 | 6.36e-01 | -0.2061 |
3219 | HOXB9 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.05e-27 | 1.07e+00 | -0.1462 |
3219 | HOXB9 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.07e-24 | 9.27e-01 | -0.0842 |
3219 | HOXB9 | HTA11_9341_2000001011 | Human | Colorectum | SER | 3.12e-22 | 1.13e+00 | -0.00410000000000005 |
3219 | HOXB9 | HTA11_7862_2000001011 | Human | Colorectum | AD | 6.13e-34 | 1.02e+00 | -0.0179 |
3219 | HOXB9 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.62e-50 | 1.07e+00 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0030879 | Colorectum | AD | mammary gland development | 53/3918 | 137/18723 | 1.46e-06 | 4.58e-05 | 53 |
GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
GO:00487321 | Colorectum | SER | gland development | 112/2897 | 436/18723 | 1.75e-08 | 1.28e-06 | 112 |
GO:00308791 | Colorectum | SER | mammary gland development | 37/2897 | 137/18723 | 3.61e-04 | 5.61e-03 | 37 |
GO:00487322 | Colorectum | MSS | gland development | 143/3467 | 436/18723 | 3.85e-13 | 8.01e-11 | 143 |
GO:00308792 | Colorectum | MSS | mammary gland development | 51/3467 | 137/18723 | 1.88e-07 | 8.26e-06 | 51 |
GO:00485681 | Colorectum | MSS | embryonic organ development | 100/3467 | 427/18723 | 6.00e-03 | 4.03e-02 | 100 |
GO:00487323 | Colorectum | MSI-H | gland development | 53/1319 | 436/18723 | 7.08e-05 | 2.35e-03 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
HOXB9 | ASC | Colorectum | AD | RP11-357H14.17,HOXB-AS4,HOXB6, etc. | 2.69e-01 | ![]() |
HOXB9 | STM | Colorectum | MSS | RP11-357H14.17,HOXB-AS4,HOXB6, etc. | 2.62e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HOXB9 | SNV | Missense_Mutation | novel | c.419C>A | p.Thr140Asn | p.T140N | P17482 | protein_coding | tolerated(0.34) | benign(0.029) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
HOXB9 | SNV | Missense_Mutation | rs778339503 | c.622N>G | p.Met208Val | p.M208V | P17482 | protein_coding | deleterious(0) | possibly_damaging(0.889) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HOXB9 | SNV | Missense_Mutation | rs199882905 | c.466N>A | p.Gly156Arg | p.G156R | P17482 | protein_coding | tolerated(0.35) | benign(0.072) | TCGA-AX-A06D-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
HOXB9 | SNV | Missense_Mutation | novel | c.419C>T | p.Thr140Ile | p.T140I | P17482 | protein_coding | tolerated(0.37) | benign(0.017) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
HOXB9 | SNV | Missense_Mutation | novel | c.65N>G | p.Asp22Gly | p.D22G | P17482 | protein_coding | deleterious(0.03) | benign(0.327) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HOXB9 | SNV | Missense_Mutation | c.710G>T | p.Arg237Leu | p.R237L | P17482 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HOXB9 | SNV | Missense_Mutation | c.161N>A | p.Pro54His | p.P54H | P17482 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-44-6144-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
HOXB9 | SNV | Missense_Mutation | novel | c.534N>G | p.Asn178Lys | p.N178K | P17482 | protein_coding | deleterious(0) | benign(0.134) | TCGA-50-5931-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HOXB9 | SNV | Missense_Mutation | novel | c.334G>T | p.Gly112Cys | p.G112C | P17482 | protein_coding | tolerated(0.19) | possibly_damaging(0.722) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
HOXB9 | SNV | Missense_Mutation | c.649N>C | p.Glu217Gln | p.E217Q | P17482 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-66-2769-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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