Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/HOMER3_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/HOMER3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/HOMER3_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/HOMER3_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/HOMER3_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/HOMER3_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000660514 | Breast | IDC | protein targeting | 43/1434 | 314/18723 | 1.44e-04 | 2.53e-03 | 43 |
GO:001095913 | Breast | IDC | regulation of metal ion transport | 52/1434 | 406/18723 | 1.76e-04 | 2.97e-03 | 52 |
GO:0032623 | Breast | IDC | interleukin-2 production | 12/1434 | 62/18723 | 2.32e-03 | 2.10e-02 | 12 |
GO:0032663 | Breast | IDC | regulation of interleukin-2 production | 12/1434 | 62/18723 | 2.32e-03 | 2.10e-02 | 12 |
GO:0032703 | Breast | IDC | negative regulation of interleukin-2 production | 7/1434 | 27/18723 | 3.46e-03 | 2.87e-02 | 7 |
GO:0051924 | Breast | IDC | regulation of calcium ion transport | 32/1434 | 255/18723 | 3.94e-03 | 3.22e-02 | 32 |
GO:000660523 | Breast | DCIS | protein targeting | 43/1390 | 314/18723 | 7.17e-05 | 1.41e-03 | 43 |
GO:001095921 | Breast | DCIS | regulation of metal ion transport | 50/1390 | 406/18723 | 2.86e-04 | 4.22e-03 | 50 |
GO:00326231 | Breast | DCIS | interleukin-2 production | 12/1390 | 62/18723 | 1.79e-03 | 1.73e-02 | 12 |
GO:00326631 | Breast | DCIS | regulation of interleukin-2 production | 12/1390 | 62/18723 | 1.79e-03 | 1.73e-02 | 12 |
GO:00327031 | Breast | DCIS | negative regulation of interleukin-2 production | 7/1390 | 27/18723 | 2.90e-03 | 2.50e-02 | 7 |
GO:00508481 | Breast | DCIS | regulation of calcium-mediated signaling | 12/1390 | 73/18723 | 7.17e-03 | 4.85e-02 | 12 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:000660512 | Liver | HCC | protein targeting | 219/7958 | 314/18723 | 7.74e-23 | 1.49e-20 | 219 |
GO:000660520 | Oral cavity | OSCC | protein targeting | 204/7305 | 314/18723 | 6.78e-21 | 1.13e-18 | 204 |
GO:00331733 | Oral cavity | OSCC | calcineurin-NFAT signaling cascade | 26/7305 | 43/18723 | 3.55e-03 | 1.49e-02 | 26 |
GO:00480164 | Oral cavity | OSCC | inositol phosphate-mediated signaling | 30/7305 | 55/18723 | 1.39e-02 | 4.59e-02 | 30 |
GO:00708843 | Oral cavity | OSCC | regulation of calcineurin-NFAT signaling cascade | 20/7305 | 34/18723 | 1.51e-02 | 4.91e-02 | 20 |
GO:0006605110 | Oral cavity | LP | protein targeting | 156/4623 | 314/18723 | 5.43e-22 | 1.62e-19 | 156 |
GO:000660527 | Skin | cSCC | protein targeting | 153/4864 | 314/18723 | 2.62e-18 | 3.36e-16 | 153 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HOMER3 | SNV | Missense_Mutation | novel | c.628G>A | p.Ala210Thr | p.A210T | Q9NSC5 | protein_coding | deleterious(0.01) | benign(0.163) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HOMER3 | SNV | Missense_Mutation | novel | c.95N>C | p.Lys32Thr | p.K32T | Q9NSC5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
HOMER3 | SNV | Missense_Mutation | novel | c.134N>A | p.Arg45His | p.R45H | Q9NSC5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HOMER3 | SNV | Missense_Mutation | novel | c.628N>A | p.Ala210Thr | p.A210T | Q9NSC5 | protein_coding | deleterious(0.01) | benign(0.163) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
HOMER3 | insertion | Frame_Shift_Ins | novel | c.742_743insCT | p.Lys248ThrfsTer28 | p.K248Tfs*28 | Q9NSC5 | protein_coding | | | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HOMER3 | insertion | Nonsense_Mutation | novel | c.741_742insTAGCTGGGATTACAGGCGCCCGCC | p.Glu247_Lys248insTer | p.E247_K248ins* | Q9NSC5 | protein_coding | | | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HOMER3 | SNV | Missense_Mutation | novel | c.478N>A | p.Ala160Thr | p.A160T | Q9NSC5 | protein_coding | tolerated(0.05) | probably_damaging(0.932) | TCGA-37-4130-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HOMER3 | SNV | Missense_Mutation | | c.505G>A | p.Glu169Lys | p.E169K | Q9NSC5 | protein_coding | tolerated(0.06) | probably_damaging(0.942) | TCGA-39-5031-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HOMER3 | SNV | Missense_Mutation | rs753159724 | c.847N>A | p.Glu283Lys | p.E283K | Q9NSC5 | protein_coding | deleterious(0.01) | possibly_damaging(0.73) | TCGA-CV-6955-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HOMER3 | SNV | Missense_Mutation | novel | c.769N>A | p.Leu257Met | p.L257M | Q9NSC5 | protein_coding | deleterious(0.01) | possibly_damaging(0.779) | TCGA-CV-7245-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |