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Gene: HIST3H2A |
Gene summary for HIST3H2A |
Gene summary. |
Gene information | Species | Human | Gene symbol | HIST3H2A | Gene ID | 92815 |
Gene name | H2A.W histone | |
Gene Alias | HIST3H2A | |
Cytomap | 1q42.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q7L7L0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92815 | HIST3H2A | GSM4909285 | Human | Breast | IDC | 4.75e-02 | 2.32e-01 | 0.21 |
92815 | HIST3H2A | GSM4909286 | Human | Breast | IDC | 3.32e-24 | 5.30e-01 | 0.1081 |
92815 | HIST3H2A | GSM4909291 | Human | Breast | IDC | 1.01e-05 | 4.05e-01 | 0.1753 |
92815 | HIST3H2A | GSM4909297 | Human | Breast | IDC | 2.30e-06 | 2.68e-01 | 0.1517 |
92815 | HIST3H2A | GSM4909302 | Human | Breast | IDC | 1.94e-02 | 2.70e-01 | 0.1545 |
92815 | HIST3H2A | GSM4909305 | Human | Breast | IDC | 1.97e-02 | 2.10e-01 | 0.0436 |
92815 | HIST3H2A | GSM4909306 | Human | Breast | IDC | 2.82e-06 | 3.61e-01 | 0.1564 |
92815 | HIST3H2A | GSM4909307 | Human | Breast | IDC | 1.06e-11 | 5.21e-01 | 0.1569 |
92815 | HIST3H2A | GSM4909308 | Human | Breast | IDC | 1.19e-23 | 5.78e-01 | 0.158 |
92815 | HIST3H2A | GSM4909311 | Human | Breast | IDC | 1.32e-12 | -6.92e-02 | 0.1534 |
92815 | HIST3H2A | GSM4909312 | Human | Breast | IDC | 3.33e-03 | -9.07e-02 | 0.1552 |
92815 | HIST3H2A | GSM4909317 | Human | Breast | IDC | 5.52e-06 | 3.66e-01 | 0.1355 |
92815 | HIST3H2A | GSM4909319 | Human | Breast | IDC | 9.29e-21 | 7.61e-02 | 0.1563 |
92815 | HIST3H2A | GSM4909321 | Human | Breast | IDC | 2.28e-04 | -1.44e-02 | 0.1559 |
92815 | HIST3H2A | brca10 | Human | Breast | Precancer | 1.26e-02 | -1.91e-01 | -0.0029 |
92815 | HIST3H2A | DCIS2 | Human | Breast | DCIS | 5.26e-27 | 6.49e-02 | 0.0085 |
92815 | HIST3H2A | LZE4T | Human | Esophagus | ESCC | 3.54e-20 | 9.80e-01 | 0.0811 |
92815 | HIST3H2A | LZE5T | Human | Esophagus | ESCC | 1.24e-02 | 4.96e-01 | 0.0514 |
92815 | HIST3H2A | LZE8T | Human | Esophagus | ESCC | 1.55e-09 | 2.78e-01 | 0.067 |
92815 | HIST3H2A | LZE20T | Human | Esophagus | ESCC | 2.45e-06 | 2.43e-01 | 0.0662 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIST3H2A | SNV | Missense_Mutation | c.122N>T | p.Ser41Leu | p.S41L | Q7L7L0 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.652) | TCGA-DD-AAC9-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HIST3H2A | SNV | Missense_Mutation | c.80N>T | p.Pro27Leu | p.P27L | Q7L7L0 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HIST3H2A | SNV | Missense_Mutation | novel | c.139N>T | p.Gly47Cys | p.G47C | Q7L7L0 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-77-6844-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
HIST3H2A | SNV | Missense_Mutation | novel | c.315G>C | p.Gln105His | p.Q105H | Q7L7L0 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.859) | TCGA-4P-AA8J-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HIST3H2A | SNV | Missense_Mutation | rs754510222 | c.56N>T | p.Ser19Leu | p.S19L | Q7L7L0 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.972) | TCGA-CG-5725-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | docetaxel | PD |
HIST3H2A | SNV | Missense_Mutation | rs762265732 | c.10C>T | p.Arg4Cys | p.R4C | Q7L7L0 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-HU-A4GF-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HIST3H2A | SNV | Missense_Mutation | c.119N>G | p.Tyr40Cys | p.Y40C | Q7L7L0 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.706) | TCGA-EL-A3CR-01 | Thyroid | thyroid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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