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Gene: HIST1H2AL |
Gene summary for HIST1H2AL |
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Gene information | Species | Human | Gene symbol | HIST1H2AL | Gene ID | 8332 |
Gene name | H2A clustered histone 16 | |
Gene Alias | H2A.i | |
Cytomap | 6p22.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A4FTV9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8332 | HIST1H2AL | LZE7T | Human | Esophagus | ESCC | 3.90e-02 | 1.58e-01 | 0.0667 |
8332 | HIST1H2AL | LZE21D1 | Human | Esophagus | HGIN | 2.75e-06 | 3.94e-01 | 0.0632 |
8332 | HIST1H2AL | LZE22D1 | Human | Esophagus | HGIN | 5.14e-03 | 2.38e-01 | 0.0595 |
8332 | HIST1H2AL | LZE21T | Human | Esophagus | ESCC | 6.52e-03 | 3.22e-01 | 0.0655 |
8332 | HIST1H2AL | P1T-E | Human | Esophagus | ESCC | 1.23e-18 | 1.13e+00 | 0.0875 |
8332 | HIST1H2AL | P2T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.65e-01 | 0.1177 |
8332 | HIST1H2AL | P4T-E | Human | Esophagus | ESCC | 2.90e-03 | 1.36e-01 | 0.1323 |
8332 | HIST1H2AL | P10T-E | Human | Esophagus | ESCC | 8.40e-04 | 9.78e-02 | 0.116 |
8332 | HIST1H2AL | P12T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.54e-01 | 0.1122 |
8332 | HIST1H2AL | P20T-E | Human | Esophagus | ESCC | 3.97e-02 | 1.78e-01 | 0.1124 |
8332 | HIST1H2AL | P24T-E | Human | Esophagus | ESCC | 3.50e-02 | 8.53e-02 | 0.1287 |
8332 | HIST1H2AL | P27T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.52e-01 | 0.1055 |
8332 | HIST1H2AL | P30T-E | Human | Esophagus | ESCC | 2.13e-03 | 1.75e-01 | 0.137 |
8332 | HIST1H2AL | P31T-E | Human | Esophagus | ESCC | 3.50e-02 | 1.13e-01 | 0.1251 |
8332 | HIST1H2AL | P32T-E | Human | Esophagus | ESCC | 1.66e-02 | 9.93e-02 | 0.1666 |
8332 | HIST1H2AL | P36T-E | Human | Esophagus | ESCC | 1.55e-04 | 1.88e-01 | 0.1187 |
8332 | HIST1H2AL | P39T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.22e-01 | 0.0894 |
8332 | HIST1H2AL | P42T-E | Human | Esophagus | ESCC | 9.05e-04 | 1.43e-01 | 0.1175 |
8332 | HIST1H2AL | P47T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.31e-01 | 0.1067 |
8332 | HIST1H2AL | P48T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.97e-01 | 0.0959 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIST1H2AL | SNV | Missense_Mutation | novel | c.26G>C | p.Gly9Ala | p.G9A | P0C0S8 | protein_coding | tolerated_low_confidence(0.12) | possibly_damaging(0.538) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIST1H2AL | insertion | In_Frame_Ins | novel | c.374_375insGAGCTC | p.His125delinsGlnSerSer | p.H125delinsQSS | P0C0S8 | protein_coding | TCGA-AP-A053-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
HIST1H2AL | SNV | Missense_Mutation | c.53N>C | p.Arg18Pro | p.R18P | P0C0S8 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.867) | TCGA-50-7109-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
HIST1H2AL | SNV | Missense_Mutation | c.59N>G | p.Ser20Cys | p.S20C | P0C0S8 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.789) | TCGA-78-7150-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD | |
HIST1H2AL | SNV | Missense_Mutation | rs778934233 | c.364N>A | p.Glu122Lys | p.E122K | P0C0S8 | protein_coding | tolerated_low_confidence(0.2) | benign(0.003) | TCGA-86-8278-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | etoposide | SD |
HIST1H2AL | SNV | Missense_Mutation | c.233N>T | p.Arg78Leu | p.R78L | P0C0S8 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.986) | TCGA-21-1070-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
HIST1H2AL | SNV | Missense_Mutation | novel | c.152N>G | p.Tyr51Cys | p.Y51C | P0C0S8 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
HIST1H2AL | SNV | Missense_Mutation | novel | c.185N>T | p.Glu62Val | p.E62V | P0C0S8 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.99) | TCGA-77-7141-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HIST1H2AL | SNV | Missense_Mutation | c.202N>A | p.Gly68Ser | p.G68S | P0C0S8 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.997) | TCGA-85-8049-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HIST1H2AL | SNV | Missense_Mutation | c.328C>A | p.Pro110Thr | p.P110T | P0C0S8 | protein_coding | deleterious_low_confidence(0.02) | benign(0.248) | TCGA-CN-6998-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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