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Gene: HIST1H2AJ |
Gene summary for HIST1H2AJ |
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Gene information | Species | Human | Gene symbol | HIST1H2AJ | Gene ID | 8331 |
Gene name | H2A clustered histone 14 | |
Gene Alias | H2A/E | |
Cytomap | 6p22.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q99878 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8331 | HIST1H2AJ | LZE21D1 | Human | Esophagus | HGIN | 5.38e-03 | 2.63e-01 | 0.0632 |
8331 | HIST1H2AJ | LZE21T | Human | Esophagus | ESCC | 9.73e-05 | 4.69e-01 | 0.0655 |
8331 | HIST1H2AJ | LZE6T | Human | Esophagus | ESCC | 1.62e-02 | 3.40e-01 | 0.0845 |
8331 | HIST1H2AJ | P1T-E | Human | Esophagus | ESCC | 1.45e-10 | 8.62e-01 | 0.0875 |
8331 | HIST1H2AJ | P4T-E | Human | Esophagus | ESCC | 3.78e-04 | 1.50e-01 | 0.1323 |
8331 | HIST1H2AJ | P5T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.43e-01 | 0.1327 |
8331 | HIST1H2AJ | P10T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.42e-01 | 0.116 |
8331 | HIST1H2AJ | P12T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.50e-01 | 0.1122 |
8331 | HIST1H2AJ | P20T-E | Human | Esophagus | ESCC | 5.73e-03 | 1.53e-01 | 0.1124 |
8331 | HIST1H2AJ | P22T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.65e-01 | 0.1236 |
8331 | HIST1H2AJ | P24T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.33e-01 | 0.1287 |
8331 | HIST1H2AJ | P27T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.70e-01 | 0.1055 |
8331 | HIST1H2AJ | P31T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.72e-01 | 0.1251 |
8331 | HIST1H2AJ | P36T-E | Human | Esophagus | ESCC | 2.82e-02 | 1.28e-01 | 0.1187 |
8331 | HIST1H2AJ | P37T-E | Human | Esophagus | ESCC | 2.88e-04 | 1.64e-01 | 0.1371 |
8331 | HIST1H2AJ | P48T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.21e-01 | 0.0959 |
8331 | HIST1H2AJ | P52T-E | Human | Esophagus | ESCC | 7.52e-23 | 6.00e-01 | 0.1555 |
8331 | HIST1H2AJ | P54T-E | Human | Esophagus | ESCC | 9.07e-08 | 2.68e-01 | 0.0975 |
8331 | HIST1H2AJ | P61T-E | Human | Esophagus | ESCC | 3.64e-10 | 4.29e-01 | 0.099 |
8331 | HIST1H2AJ | P62T-E | Human | Esophagus | ESCC | 2.57e-02 | 1.42e-01 | 0.1302 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIST1H2AJ | SNV | Missense_Mutation | c.43N>A | p.Ala15Thr | p.A15T | Q99878 | protein_coding | tolerated_low_confidence(0.07) | possibly_damaging(0.564) | TCGA-DI-A0WH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HIST1H2AJ | SNV | Missense_Mutation | novel | c.328N>T | p.Pro110Ser | p.P110S | Q99878 | protein_coding | deleterious_low_confidence(0) | benign(0.123) | TCGA-EO-A22T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIST1H2AJ | SNV | Missense_Mutation | novel | c.353N>T | p.Pro118Leu | p.P118L | Q99878 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.964) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIST1H2AJ | SNV | Missense_Mutation | novel | c.230N>T | p.Thr77Ile | p.T77I | Q99878 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.741) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIST1H2AJ | SNV | Missense_Mutation | novel | c.172N>C | p.Tyr58His | p.Y58H | Q99878 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(1) | TCGA-EY-A5W2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIST1H2AJ | SNV | Missense_Mutation | novel | c.126N>T | p.Glu42Asp | p.E42D | Q99878 | protein_coding | tolerated_low_confidence(0.07) | benign(0.007) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD |
HIST1H2AJ | SNV | Missense_Mutation | c.271N>A | p.Asp91Asn | p.D91N | Q99878 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-64-1678-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
HIST1H2AJ | SNV | Missense_Mutation | c.34N>T | p.Arg12Cys | p.R12C | Q99878 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.864) | TCGA-95-7948-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HIST1H2AJ | SNV | Missense_Mutation | c.357N>C | p.Lys119Asn | p.K119N | Q99878 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.87) | TCGA-MP-A4SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HIST1H2AJ | SNV | Missense_Mutation | novel | c.62N>T | p.Arg21Leu | p.R21L | Q99878 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.903) | TCGA-56-7222-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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